Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis

Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nit...
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Autor*in:	Reema Ghodmare [verfasserIn] Rahul Narang [verfasserIn] Pratibha Narang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	India multidrug-resistant tuberculosis nitrate reductase assay tuberculosis

Übergeordnetes Werk:	In: Journal of Mahatma Gandhi Institute of Medical Sciences - Wolters Kluwer Medknow Publications, 2018, 24(2019), 2, Seite 78-81
Übergeordnetes Werk:	volume:24 ; year:2019 ; number:2 ; pages:78-81

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/jmgims.jmgims_59_16

Katalog-ID:	DOAJ048023922

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allfieldsGer	10.4103/jmgims.jmgims_59_16 doi (DE-627)DOAJ048023922 (DE-599)DOAJd6a8a403f82e4a5db19116445b14b332 DE-627 ger DE-627 rakwb eng RZ201-999 Reema Ghodmare verfasserin aut Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nitrate reductase assay (NRA) on solid Lowenstein–Jensen (LJ) medium with proportion method on LJ medium as reference standard. Materials and Methods: From November 2011 to July 2012, 100 isolates of M. tuberculosis were tested for susceptibility to first-line drugs on LJ medium by proportion method and NRA using LJ with potassium nitrate. Results: For various drugs, the sensitivity and specificity by NRA on solid medium were as follows: streptomycin 96.6% and 98.5%; isoniazid 96.87% and 97%; rifampicin 96.3% and 96%; and ethambutol 78.9% and 91.4%, respectively. The concordance for rifampicin and isoniazid between NRA method and LJ proportion method was found to be <95%. Conclusion: NRA was found to be a rapid and sensitive method for DST of M. tuberculosis. India multidrug-resistant tuberculosis nitrate reductase assay tuberculosis Medicine R Other systems of medicine Rahul Narang verfasserin aut Pratibha Narang verfasserin aut In Journal of Mahatma Gandhi Institute of Medical Sciences Wolters Kluwer Medknow Publications, 2018 24(2019), 2, Seite 78-81 (DE-627)77127498X (DE-600)2738506-1 23471948 nnns volume:24 year:2019 number:2 pages:78-81 https://doi.org/10.4103/jmgims.jmgims_59_16 kostenfrei https://doaj.org/article/d6a8a403f82e4a5db19116445b14b332 kostenfrei http://www.jmgims.co.in/article.asp?issn=0971-9903;year=2019;volume=24;issue=2;spage=78;epage=81;aulast=Ghodmare kostenfrei https://doaj.org/toc/0971-9903 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 2 78-81
allfieldsSound	10.4103/jmgims.jmgims_59_16 doi (DE-627)DOAJ048023922 (DE-599)DOAJd6a8a403f82e4a5db19116445b14b332 DE-627 ger DE-627 rakwb eng RZ201-999 Reema Ghodmare verfasserin aut Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nitrate reductase assay (NRA) on solid Lowenstein–Jensen (LJ) medium with proportion method on LJ medium as reference standard. Materials and Methods: From November 2011 to July 2012, 100 isolates of M. tuberculosis were tested for susceptibility to first-line drugs on LJ medium by proportion method and NRA using LJ with potassium nitrate. Results: For various drugs, the sensitivity and specificity by NRA on solid medium were as follows: streptomycin 96.6% and 98.5%; isoniazid 96.87% and 97%; rifampicin 96.3% and 96%; and ethambutol 78.9% and 91.4%, respectively. The concordance for rifampicin and isoniazid between NRA method and LJ proportion method was found to be <95%. Conclusion: NRA was found to be a rapid and sensitive method for DST of M. tuberculosis. India multidrug-resistant tuberculosis nitrate reductase assay tuberculosis Medicine R Other systems of medicine Rahul Narang verfasserin aut Pratibha Narang verfasserin aut In Journal of Mahatma Gandhi Institute of Medical Sciences Wolters Kluwer Medknow Publications, 2018 24(2019), 2, Seite 78-81 (DE-627)77127498X (DE-600)2738506-1 23471948 nnns volume:24 year:2019 number:2 pages:78-81 https://doi.org/10.4103/jmgims.jmgims_59_16 kostenfrei https://doaj.org/article/d6a8a403f82e4a5db19116445b14b332 kostenfrei http://www.jmgims.co.in/article.asp?issn=0971-9903;year=2019;volume=24;issue=2;spage=78;epage=81;aulast=Ghodmare kostenfrei https://doaj.org/toc/0971-9903 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 2 78-81
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callnumber-first	R - Medicine
author	Reema Ghodmare
spellingShingle	Reema Ghodmare misc RZ201-999 misc India misc multidrug-resistant tuberculosis misc nitrate reductase assay misc tuberculosis misc Medicine misc R misc Other systems of medicine Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis
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topic_title	RZ201-999 Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis India multidrug-resistant tuberculosis nitrate reductase assay tuberculosis
topic	misc RZ201-999 misc India misc multidrug-resistant tuberculosis misc nitrate reductase assay misc tuberculosis misc Medicine misc R misc Other systems of medicine
topic_unstemmed	misc RZ201-999 misc India misc multidrug-resistant tuberculosis misc nitrate reductase assay misc tuberculosis misc Medicine misc R misc Other systems of medicine
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title	Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis
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title_full	Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis
author_sort	Reema Ghodmare
journal	Journal of Mahatma Gandhi Institute of Medical Sciences
journalStr	Journal of Mahatma Gandhi Institute of Medical Sciences
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author_browse	Reema Ghodmare Rahul Narang Pratibha Narang
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author-letter	Reema Ghodmare
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title_sort	evaluation of nitrate reductase assay on lowenstein–jensen medium for drug susceptibility testing of mycobacterium tuberculosis
callnumber	RZ201-999
title_auth	Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis
abstract	Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nitrate reductase assay (NRA) on solid Lowenstein–Jensen (LJ) medium with proportion method on LJ medium as reference standard. Materials and Methods: From November 2011 to July 2012, 100 isolates of M. tuberculosis were tested for susceptibility to first-line drugs on LJ medium by proportion method and NRA using LJ with potassium nitrate. Results: For various drugs, the sensitivity and specificity by NRA on solid medium were as follows: streptomycin 96.6% and 98.5%; isoniazid 96.87% and 97%; rifampicin 96.3% and 96%; and ethambutol 78.9% and 91.4%, respectively. The concordance for rifampicin and isoniazid between NRA method and LJ proportion method was found to be <95%. Conclusion: NRA was found to be a rapid and sensitive method for DST of M. tuberculosis.
abstractGer	Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nitrate reductase assay (NRA) on solid Lowenstein–Jensen (LJ) medium with proportion method on LJ medium as reference standard. Materials and Methods: From November 2011 to July 2012, 100 isolates of M. tuberculosis were tested for susceptibility to first-line drugs on LJ medium by proportion method and NRA using LJ with potassium nitrate. Results: For various drugs, the sensitivity and specificity by NRA on solid medium were as follows: streptomycin 96.6% and 98.5%; isoniazid 96.87% and 97%; rifampicin 96.3% and 96%; and ethambutol 78.9% and 91.4%, respectively. The concordance for rifampicin and isoniazid between NRA method and LJ proportion method was found to be <95%. Conclusion: NRA was found to be a rapid and sensitive method for DST of M. tuberculosis.
abstract_unstemmed	Introduction: Multidrug-resistant tuberculosis is of increasing public health concern and a rapid and inexpensive drug susceptibility test is needed in resource limited settings. Aim: This study aims to compare the efficacy of drug susceptibility testing (DST) of Mycobacterium tuberculosis using nitrate reductase assay (NRA) on solid Lowenstein–Jensen (LJ) medium with proportion method on LJ medium as reference standard. Materials and Methods: From November 2011 to July 2012, 100 isolates of M. tuberculosis were tested for susceptibility to first-line drugs on LJ medium by proportion method and NRA using LJ with potassium nitrate. Results: For various drugs, the sensitivity and specificity by NRA on solid medium were as follows: streptomycin 96.6% and 98.5%; isoniazid 96.87% and 97%; rifampicin 96.3% and 96%; and ethambutol 78.9% and 91.4%, respectively. The concordance for rifampicin and isoniazid between NRA method and LJ proportion method was found to be <95%. Conclusion: NRA was found to be a rapid and sensitive method for DST of M. tuberculosis.
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title_short	Evaluation of nitrate reductase assay on Lowenstein–Jensen medium for drug susceptibility testing of Mycobacterium tuberculosis
url	https://doi.org/10.4103/jmgims.jmgims_59_16 https://doaj.org/article/d6a8a403f82e4a5db19116445b14b332 http://www.jmgims.co.in/article.asp?issn=0971-9903;year=2019;volume=24;issue=2;spage=78;epage=81;aulast=Ghodmare https://doaj.org/toc/0971-9903
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up_date	2024-07-03T15:29:49.794Z
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