Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.

<h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, th...
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Autor*in:	Giacomo Zoppini [verfasserIn] Anna Galletti [verfasserIn] Giovanni Targher [verfasserIn] Corinna Brangani [verfasserIn] Isabella Pichiri [verfasserIn] Carlo Negri [verfasserIn] Vincenzo Stoico [verfasserIn] Vittorio Cacciatori [verfasserIn] Enzo Bonora [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 8(2013), 12, p e82733
Übergeordnetes Werk:	volume:8 ; year:2013 ; number:12, p e82733

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0082733

Katalog-ID:	DOAJ048095605

Internformat


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245	1	0	\|a Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
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520			\|a <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.
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700	0		\|a Enzo Bonora \|e verfasserin \|4 aut
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allfields	10.1371/journal.pone.0082733 doi (DE-627)DOAJ048095605 (DE-599)DOAJabd8285e4c1a44a1af619f4727f4c38f DE-627 ger DE-627 rakwb eng Giacomo Zoppini verfasserin aut Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes. Medicine R Science Q Anna Galletti verfasserin aut Giovanni Targher verfasserin aut Corinna Brangani verfasserin aut Isabella Pichiri verfasserin aut Carlo Negri verfasserin aut Vincenzo Stoico verfasserin aut Vittorio Cacciatori verfasserin aut Enzo Bonora verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 12, p e82733 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:12, p e82733 https://doi.org/10.1371/journal.pone.0082733 kostenfrei https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 12, p e82733
spelling	10.1371/journal.pone.0082733 doi (DE-627)DOAJ048095605 (DE-599)DOAJabd8285e4c1a44a1af619f4727f4c38f DE-627 ger DE-627 rakwb eng Giacomo Zoppini verfasserin aut Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes. Medicine R Science Q Anna Galletti verfasserin aut Giovanni Targher verfasserin aut Corinna Brangani verfasserin aut Isabella Pichiri verfasserin aut Carlo Negri verfasserin aut Vincenzo Stoico verfasserin aut Vittorio Cacciatori verfasserin aut Enzo Bonora verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 12, p e82733 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:12, p e82733 https://doi.org/10.1371/journal.pone.0082733 kostenfrei https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 12, p e82733
allfields_unstemmed	10.1371/journal.pone.0082733 doi (DE-627)DOAJ048095605 (DE-599)DOAJabd8285e4c1a44a1af619f4727f4c38f DE-627 ger DE-627 rakwb eng Giacomo Zoppini verfasserin aut Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes. Medicine R Science Q Anna Galletti verfasserin aut Giovanni Targher verfasserin aut Corinna Brangani verfasserin aut Isabella Pichiri verfasserin aut Carlo Negri verfasserin aut Vincenzo Stoico verfasserin aut Vittorio Cacciatori verfasserin aut Enzo Bonora verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 12, p e82733 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:12, p e82733 https://doi.org/10.1371/journal.pone.0082733 kostenfrei https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 12, p e82733
allfieldsGer	10.1371/journal.pone.0082733 doi (DE-627)DOAJ048095605 (DE-599)DOAJabd8285e4c1a44a1af619f4727f4c38f DE-627 ger DE-627 rakwb eng Giacomo Zoppini verfasserin aut Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes. Medicine R Science Q Anna Galletti verfasserin aut Giovanni Targher verfasserin aut Corinna Brangani verfasserin aut Isabella Pichiri verfasserin aut Carlo Negri verfasserin aut Vincenzo Stoico verfasserin aut Vittorio Cacciatori verfasserin aut Enzo Bonora verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 12, p e82733 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:12, p e82733 https://doi.org/10.1371/journal.pone.0082733 kostenfrei https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 12, p e82733
allfieldsSound	10.1371/journal.pone.0082733 doi (DE-627)DOAJ048095605 (DE-599)DOAJabd8285e4c1a44a1af619f4727f4c38f DE-627 ger DE-627 rakwb eng Giacomo Zoppini verfasserin aut Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes. Medicine R Science Q Anna Galletti verfasserin aut Giovanni Targher verfasserin aut Corinna Brangani verfasserin aut Isabella Pichiri verfasserin aut Carlo Negri verfasserin aut Vincenzo Stoico verfasserin aut Vittorio Cacciatori verfasserin aut Enzo Bonora verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 12, p e82733 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:12, p e82733 https://doi.org/10.1371/journal.pone.0082733 kostenfrei https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 12, p e82733
language	English
source	In PLoS ONE 8(2013), 12, p e82733 volume:8 year:2013 number:12, p e82733
sourceStr	In PLoS ONE 8(2013), 12, p e82733 volume:8 year:2013 number:12, p e82733
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Giacomo Zoppini @@aut@@ Anna Galletti @@aut@@ Giovanni Targher @@aut@@ Corinna Brangani @@aut@@ Isabella Pichiri @@aut@@ Carlo Negri @@aut@@ Vincenzo Stoico @@aut@@ Vittorio Cacciatori @@aut@@ Enzo Bonora @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ048095605
language_de	englisch
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author	Giacomo Zoppini
spellingShingle	Giacomo Zoppini misc Medicine misc R misc Science misc Q Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
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topic_title	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients
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title	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
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title_full	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients
author_sort	Giacomo Zoppini
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author_browse	Giacomo Zoppini Anna Galletti Giovanni Targher Corinna Brangani Isabella Pichiri Carlo Negri Vincenzo Stoico Vittorio Cacciatori Enzo Bonora
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author-letter	Giacomo Zoppini
doi_str_mv	10.1371/journal.pone.0082733
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title_sort	glycated haemoglobin is inversely related to serum vitamin d levels in type 2 diabetic patients
title_auth	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
abstract	<h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.
abstractGer	<h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.
abstract_unstemmed	<h4<Objective</h4<A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4<Research design and methods</h4<We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4<Results</h4<Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4<Conclusions</h4<In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.
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title_short	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
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Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.

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