HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY
ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old fema...
Ausführliche Beschreibung
Autor*in: |
Mariela Granero Farias [verfasserIn] Priscila Aparecida Correa Freitas [verfasserIn] Fabiane Spagnol [verfasserIn] Meriene Viquetti de Souza [verfasserIn] Ana Paula Alegretti [verfasserIn] Mariluce Riegel [verfasserIn] Adriano Nori Rodrigues Taniguchi [verfasserIn] Liane Esteves Daudt [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch ; Spanisch ; Portugiesisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Revista Paulista de Pediatria - Sociedade de Pediatria de São Paulo, 2008, 39(2020) |
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Übergeordnetes Werk: |
volume:39 ; year:2020 |
Links: |
Link aufrufen |
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DOI / URN: |
10.1590/1984-0462/2021/39/2019290 |
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Katalog-ID: |
DOAJ048143324 |
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10.1590/1984-0462/2021/39/2019290 doi (DE-627)DOAJ048143324 (DE-599)DOAJ96c576049f554a588ff05c1b4edc10af DE-627 ger DE-627 rakwb eng spa por RJ1-570 Mariela Granero Farias verfasserin aut HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. Acute monocytic leukemia Hemophagocytic lymphohistiocytosis Hemophagocytic syndrome Macrophage activation syndrome Pediatrics Priscila Aparecida Correa Freitas verfasserin aut Fabiane Spagnol verfasserin aut Meriene Viquetti de Souza verfasserin aut Ana Paula Alegretti verfasserin aut Mariluce Riegel verfasserin aut Adriano Nori Rodrigues Taniguchi verfasserin aut Liane Esteves Daudt verfasserin aut In Revista Paulista de Pediatria Sociedade de Pediatria de São Paulo, 2008 39(2020) (DE-627)630360057 (DE-600)2560228-7 19840462 nnns volume:39 year:2020 https://doi.org/10.1590/1984-0462/2021/39/2019290 kostenfrei https://doaj.org/article/96c576049f554a588ff05c1b4edc10af kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=pt kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=en kostenfrei https://doaj.org/toc/1984-0462 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 |
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10.1590/1984-0462/2021/39/2019290 doi (DE-627)DOAJ048143324 (DE-599)DOAJ96c576049f554a588ff05c1b4edc10af DE-627 ger DE-627 rakwb eng spa por RJ1-570 Mariela Granero Farias verfasserin aut HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. Acute monocytic leukemia Hemophagocytic lymphohistiocytosis Hemophagocytic syndrome Macrophage activation syndrome Pediatrics Priscila Aparecida Correa Freitas verfasserin aut Fabiane Spagnol verfasserin aut Meriene Viquetti de Souza verfasserin aut Ana Paula Alegretti verfasserin aut Mariluce Riegel verfasserin aut Adriano Nori Rodrigues Taniguchi verfasserin aut Liane Esteves Daudt verfasserin aut In Revista Paulista de Pediatria Sociedade de Pediatria de São Paulo, 2008 39(2020) (DE-627)630360057 (DE-600)2560228-7 19840462 nnns volume:39 year:2020 https://doi.org/10.1590/1984-0462/2021/39/2019290 kostenfrei https://doaj.org/article/96c576049f554a588ff05c1b4edc10af kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=pt kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=en kostenfrei https://doaj.org/toc/1984-0462 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 |
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10.1590/1984-0462/2021/39/2019290 doi (DE-627)DOAJ048143324 (DE-599)DOAJ96c576049f554a588ff05c1b4edc10af DE-627 ger DE-627 rakwb eng spa por RJ1-570 Mariela Granero Farias verfasserin aut HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. Acute monocytic leukemia Hemophagocytic lymphohistiocytosis Hemophagocytic syndrome Macrophage activation syndrome Pediatrics Priscila Aparecida Correa Freitas verfasserin aut Fabiane Spagnol verfasserin aut Meriene Viquetti de Souza verfasserin aut Ana Paula Alegretti verfasserin aut Mariluce Riegel verfasserin aut Adriano Nori Rodrigues Taniguchi verfasserin aut Liane Esteves Daudt verfasserin aut In Revista Paulista de Pediatria Sociedade de Pediatria de São Paulo, 2008 39(2020) (DE-627)630360057 (DE-600)2560228-7 19840462 nnns volume:39 year:2020 https://doi.org/10.1590/1984-0462/2021/39/2019290 kostenfrei https://doaj.org/article/96c576049f554a588ff05c1b4edc10af kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=pt kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=en kostenfrei https://doaj.org/toc/1984-0462 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 |
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10.1590/1984-0462/2021/39/2019290 doi (DE-627)DOAJ048143324 (DE-599)DOAJ96c576049f554a588ff05c1b4edc10af DE-627 ger DE-627 rakwb eng spa por RJ1-570 Mariela Granero Farias verfasserin aut HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. Acute monocytic leukemia Hemophagocytic lymphohistiocytosis Hemophagocytic syndrome Macrophage activation syndrome Pediatrics Priscila Aparecida Correa Freitas verfasserin aut Fabiane Spagnol verfasserin aut Meriene Viquetti de Souza verfasserin aut Ana Paula Alegretti verfasserin aut Mariluce Riegel verfasserin aut Adriano Nori Rodrigues Taniguchi verfasserin aut Liane Esteves Daudt verfasserin aut In Revista Paulista de Pediatria Sociedade de Pediatria de São Paulo, 2008 39(2020) (DE-627)630360057 (DE-600)2560228-7 19840462 nnns volume:39 year:2020 https://doi.org/10.1590/1984-0462/2021/39/2019290 kostenfrei https://doaj.org/article/96c576049f554a588ff05c1b4edc10af kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=pt kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=en kostenfrei https://doaj.org/toc/1984-0462 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2020 |
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HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY |
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ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. |
abstractGer |
ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. |
abstract_unstemmed |
ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia. |
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title_short |
HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY |
url |
https://doi.org/10.1590/1984-0462/2021/39/2019290 https://doaj.org/article/96c576049f554a588ff05c1b4edc10af http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=pt http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100601&tlng=en https://doaj.org/toc/1984-0462 |
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Priscila Aparecida Correa Freitas Fabiane Spagnol Meriene Viquetti de Souza Ana Paula Alegretti Mariluce Riegel Adriano Nori Rodrigues Taniguchi Liane Esteves Daudt |
author2Str |
Priscila Aparecida Correa Freitas Fabiane Spagnol Meriene Viquetti de Souza Ana Paula Alegretti Mariluce Riegel Adriano Nori Rodrigues Taniguchi Liane Esteves Daudt |
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doi_str |
10.1590/1984-0462/2021/39/2019290 |
callnumber-a |
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up_date |
2024-07-03T16:10:17.110Z |
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