SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin

The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and...
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Autor*in:	Liyan Lv [verfasserIn] Min Zhou [verfasserIn] Jian Zhang [verfasserIn] Fang Liu [verfasserIn] Li Qi [verfasserIn] Shuai Zhang [verfasserIn] Yi Bi [verfasserIn] Yan Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6

Übergeordnetes Werk:	In: FEBS Open Bio - Wiley, 2013, 10(2020), 1, Seite 135-146
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:1 ; pages:135-146

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/2211-5463.12762

Katalog-ID:	DOAJ048160288

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520			\|a The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.
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allfields	10.1002/2211-5463.12762 doi (DE-627)DOAJ048160288 (DE-599)DOAJ4c1b15fb989548e48205cf7018ee82bc DE-627 ger DE-627 rakwb eng QH301-705.5 Liyan Lv verfasserin aut SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General) Min Zhou verfasserin aut Jian Zhang verfasserin aut Fang Liu verfasserin aut Li Qi verfasserin aut Shuai Zhang verfasserin aut Yi Bi verfasserin aut Yan Yu verfasserin aut In FEBS Open Bio Wiley, 2013 10(2020), 1, Seite 135-146 (DE-627)686948351 (DE-600)2651702-4 22115463 nnns volume:10 year:2020 number:1 pages:135-146 https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc kostenfrei https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/toc/2211-5463 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 135-146
spelling	10.1002/2211-5463.12762 doi (DE-627)DOAJ048160288 (DE-599)DOAJ4c1b15fb989548e48205cf7018ee82bc DE-627 ger DE-627 rakwb eng QH301-705.5 Liyan Lv verfasserin aut SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General) Min Zhou verfasserin aut Jian Zhang verfasserin aut Fang Liu verfasserin aut Li Qi verfasserin aut Shuai Zhang verfasserin aut Yi Bi verfasserin aut Yan Yu verfasserin aut In FEBS Open Bio Wiley, 2013 10(2020), 1, Seite 135-146 (DE-627)686948351 (DE-600)2651702-4 22115463 nnns volume:10 year:2020 number:1 pages:135-146 https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc kostenfrei https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/toc/2211-5463 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 135-146
allfields_unstemmed	10.1002/2211-5463.12762 doi (DE-627)DOAJ048160288 (DE-599)DOAJ4c1b15fb989548e48205cf7018ee82bc DE-627 ger DE-627 rakwb eng QH301-705.5 Liyan Lv verfasserin aut SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General) Min Zhou verfasserin aut Jian Zhang verfasserin aut Fang Liu verfasserin aut Li Qi verfasserin aut Shuai Zhang verfasserin aut Yi Bi verfasserin aut Yan Yu verfasserin aut In FEBS Open Bio Wiley, 2013 10(2020), 1, Seite 135-146 (DE-627)686948351 (DE-600)2651702-4 22115463 nnns volume:10 year:2020 number:1 pages:135-146 https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc kostenfrei https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/toc/2211-5463 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 135-146
allfieldsGer	10.1002/2211-5463.12762 doi (DE-627)DOAJ048160288 (DE-599)DOAJ4c1b15fb989548e48205cf7018ee82bc DE-627 ger DE-627 rakwb eng QH301-705.5 Liyan Lv verfasserin aut SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General) Min Zhou verfasserin aut Jian Zhang verfasserin aut Fang Liu verfasserin aut Li Qi verfasserin aut Shuai Zhang verfasserin aut Yi Bi verfasserin aut Yan Yu verfasserin aut In FEBS Open Bio Wiley, 2013 10(2020), 1, Seite 135-146 (DE-627)686948351 (DE-600)2651702-4 22115463 nnns volume:10 year:2020 number:1 pages:135-146 https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc kostenfrei https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/toc/2211-5463 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 135-146
allfieldsSound	10.1002/2211-5463.12762 doi (DE-627)DOAJ048160288 (DE-599)DOAJ4c1b15fb989548e48205cf7018ee82bc DE-627 ger DE-627 rakwb eng QH301-705.5 Liyan Lv verfasserin aut SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma. β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General) Min Zhou verfasserin aut Jian Zhang verfasserin aut Fang Liu verfasserin aut Li Qi verfasserin aut Shuai Zhang verfasserin aut Yi Bi verfasserin aut Yan Yu verfasserin aut In FEBS Open Bio Wiley, 2013 10(2020), 1, Seite 135-146 (DE-627)686948351 (DE-600)2651702-4 22115463 nnns volume:10 year:2020 number:1 pages:135-146 https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc kostenfrei https://doi.org/10.1002/2211-5463.12762 kostenfrei https://doaj.org/toc/2211-5463 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 135-146
language	English
source	In FEBS Open Bio 10(2020), 1, Seite 135-146 volume:10 year:2020 number:1 pages:135-146
sourceStr	In FEBS Open Bio 10(2020), 1, Seite 135-146 volume:10 year:2020 number:1 pages:135-146
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6 Biology (General)
isfreeaccess_bool	true
container_title	FEBS Open Bio
authorswithroles_txt_mv	Liyan Lv @@aut@@ Min Zhou @@aut@@ Jian Zhang @@aut@@ Fang Liu @@aut@@ Li Qi @@aut@@ Shuai Zhang @@aut@@ Yi Bi @@aut@@ Yan Yu @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	686948351
id	DOAJ048160288
language_de	englisch
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callnumber-first	Q - Science
author	Liyan Lv
spellingShingle	Liyan Lv misc QH301-705.5 misc β‐catenin misc cyclin D1 misc lung adenocarcinoma misc p21CIPI misc p53 misc SOX6 misc Biology (General) SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin
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topic_title	QH301-705.5 SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin β‐catenin cyclin D1 lung adenocarcinoma p21CIPI p53 SOX6
topic	misc QH301-705.5 misc β‐catenin misc cyclin D1 misc lung adenocarcinoma misc p21CIPI misc p53 misc SOX6 misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc β‐catenin misc cyclin D1 misc lung adenocarcinoma misc p21CIPI misc p53 misc SOX6 misc Biology (General)
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title	SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin
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title_full	SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin
author_sort	Liyan Lv
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author_browse	Liyan Lv Min Zhou Jian Zhang Fang Liu Li Qi Shuai Zhang Yi Bi Yan Yu
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title_sort	sox6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21cipi, cyclin d1 and β‐catenin
callnumber	QH301-705.5
title_auth	SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin
abstract	The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.
abstractGer	The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.
abstract_unstemmed	The Sry‐related high‐mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down‐regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up‐regulation of p53 and p21CIPI and down‐regulation of cyclin D1 and β‐catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease‐related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.
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title_short	SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin
url	https://doi.org/10.1002/2211-5463.12762 https://doaj.org/article/4c1b15fb989548e48205cf7018ee82bc https://doaj.org/toc/2211-5463
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SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21CIPI, cyclin D1 and β‐catenin

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