Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset

Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are asso...
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Gespeichert in:

Autor*in:	Xin-hong Jiang [verfasserIn] Ke-xu Lin [verfasserIn] Yi-xian Zhang [verfasserIn] Rong-hua Chen [verfasserIn] Nan Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration

Übergeordnetes Werk:	In: Neural Regeneration Research - Wolters Kluwer Medknow Publications, 2014, 10(2015), 11, Seite 1809-1813
Übergeordnetes Werk:	volume:10 ; year:2015 ; number:11 ; pages:1809-1813

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/1673-5374.170308

Katalog-ID:	DOAJ048190144

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allfields	10.4103/1673-5374.170308 doi (DE-627)DOAJ048190144 (DE-599)DOAJ81ea42d6a79d49ccb844f2b5fd08005e DE-627 ger DE-627 rakwb eng RC346-429 Xin-hong Jiang verfasserin aut Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction. neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration Neurology. Diseases of the nervous system Ke-xu Lin verfasserin aut Yi-xian Zhang verfasserin aut Rong-hua Chen verfasserin aut Nan Liu verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 10(2015), 11, Seite 1809-1813 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:10 year:2015 number:11 pages:1809-1813 https://doi.org/10.4103/1673-5374.170308 kostenfrei https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11 1809-1813
spelling	10.4103/1673-5374.170308 doi (DE-627)DOAJ048190144 (DE-599)DOAJ81ea42d6a79d49ccb844f2b5fd08005e DE-627 ger DE-627 rakwb eng RC346-429 Xin-hong Jiang verfasserin aut Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction. neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration Neurology. Diseases of the nervous system Ke-xu Lin verfasserin aut Yi-xian Zhang verfasserin aut Rong-hua Chen verfasserin aut Nan Liu verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 10(2015), 11, Seite 1809-1813 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:10 year:2015 number:11 pages:1809-1813 https://doi.org/10.4103/1673-5374.170308 kostenfrei https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11 1809-1813
allfields_unstemmed	10.4103/1673-5374.170308 doi (DE-627)DOAJ048190144 (DE-599)DOAJ81ea42d6a79d49ccb844f2b5fd08005e DE-627 ger DE-627 rakwb eng RC346-429 Xin-hong Jiang verfasserin aut Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction. neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration Neurology. Diseases of the nervous system Ke-xu Lin verfasserin aut Yi-xian Zhang verfasserin aut Rong-hua Chen verfasserin aut Nan Liu verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 10(2015), 11, Seite 1809-1813 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:10 year:2015 number:11 pages:1809-1813 https://doi.org/10.4103/1673-5374.170308 kostenfrei https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11 1809-1813
allfieldsGer	10.4103/1673-5374.170308 doi (DE-627)DOAJ048190144 (DE-599)DOAJ81ea42d6a79d49ccb844f2b5fd08005e DE-627 ger DE-627 rakwb eng RC346-429 Xin-hong Jiang verfasserin aut Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction. neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration Neurology. Diseases of the nervous system Ke-xu Lin verfasserin aut Yi-xian Zhang verfasserin aut Rong-hua Chen verfasserin aut Nan Liu verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 10(2015), 11, Seite 1809-1813 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:10 year:2015 number:11 pages:1809-1813 https://doi.org/10.4103/1673-5374.170308 kostenfrei https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11 1809-1813
allfieldsSound	10.4103/1673-5374.170308 doi (DE-627)DOAJ048190144 (DE-599)DOAJ81ea42d6a79d49ccb844f2b5fd08005e DE-627 ger DE-627 rakwb eng RC346-429 Xin-hong Jiang verfasserin aut Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction. neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration Neurology. Diseases of the nervous system Ke-xu Lin verfasserin aut Yi-xian Zhang verfasserin aut Rong-hua Chen verfasserin aut Nan Liu verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 10(2015), 11, Seite 1809-1813 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:10 year:2015 number:11 pages:1809-1813 https://doi.org/10.4103/1673-5374.170308 kostenfrei https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11 1809-1813
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callnumber-first	R - Medicine
author	Xin-hong Jiang
spellingShingle	Xin-hong Jiang misc RC346-429 misc neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration misc Neurology. Diseases of the nervous system Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
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topic_title	RC346-429 Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration
topic	misc RC346-429 misc neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration misc Neurology. Diseases of the nervous system
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title	Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
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title_full	Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
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title_sort	correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
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title_auth	Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
abstract	Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.
abstractGer	Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.
abstract_unstemmed	Evidence suggests that interleukin-10 (IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites -1082 (A/G) and -819 (C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction (cerebral infarction group) and 115 healthy subjects (control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups (χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group (92.3%) than in the control group (86.1%) (P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype (OR = 2.031, 95%CI: 1.134-3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.
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title_short	Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset
url	https://doi.org/10.4103/1673-5374.170308 https://doaj.org/article/81ea42d6a79d49ccb844f2b5fd08005e http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1809;epage=1813;aulast=Jiang https://doaj.org/toc/1673-5374
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In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction (OR = 2.073, 95%CI: 1.278-3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups (P < 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">neural regeneration; IL-10; promoter; gene polymorphisms; ischemic stroke; genetic susceptibility; inflammation; immune response; ischemia/ reperfusion injury; neural regeneration</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurology. 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Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset

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