Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.

Gespeichert in:

Autor*in:	Susan E. Tsutakawa [verfasserIn] Mark J. Thompson [verfasserIn] Andrew S. Arvai [verfasserIn] Alexander J. Neil [verfasserIn] Steven J. Shaw [verfasserIn] Sana I. Algasaier [verfasserIn] Jane C. Kim [verfasserIn] L. David Finger [verfasserIn] Emma Jardine [verfasserIn] Victoria J.B. Gotham [verfasserIn] Altaf H. Sarker [verfasserIn] Mai Z. Her [verfasserIn] Fahad Rashid [verfasserIn] Samir M. Hamdan [verfasserIn] Sergei M. Mirkin [verfasserIn] Jane A. Grasby [verfasserIn] John A. Tainer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 15
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms15855

Katalog-ID:	DOAJ048299057

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allfields	10.1038/ncomms15855 doi (DE-627)DOAJ048299057 (DE-599)DOAJ7d8f8666ae664b27be8155fb17c1e260 DE-627 ger DE-627 rakwb eng Susan E. Tsutakawa verfasserin aut Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’. Science Q Mark J. Thompson verfasserin aut Andrew S. Arvai verfasserin aut Alexander J. Neil verfasserin aut Steven J. Shaw verfasserin aut Sana I. Algasaier verfasserin aut Jane C. Kim verfasserin aut L. David Finger verfasserin aut Emma Jardine verfasserin aut Victoria J.B. Gotham verfasserin aut Altaf H. Sarker verfasserin aut Mai Z. Her verfasserin aut Fahad Rashid verfasserin aut Samir M. Hamdan verfasserin aut Sergei M. Mirkin verfasserin aut Jane A. Grasby verfasserin aut John A. Tainer verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:15 https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260 kostenfrei https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 15
spelling	10.1038/ncomms15855 doi (DE-627)DOAJ048299057 (DE-599)DOAJ7d8f8666ae664b27be8155fb17c1e260 DE-627 ger DE-627 rakwb eng Susan E. Tsutakawa verfasserin aut Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’. Science Q Mark J. Thompson verfasserin aut Andrew S. Arvai verfasserin aut Alexander J. Neil verfasserin aut Steven J. Shaw verfasserin aut Sana I. Algasaier verfasserin aut Jane C. Kim verfasserin aut L. David Finger verfasserin aut Emma Jardine verfasserin aut Victoria J.B. Gotham verfasserin aut Altaf H. Sarker verfasserin aut Mai Z. Her verfasserin aut Fahad Rashid verfasserin aut Samir M. Hamdan verfasserin aut Sergei M. Mirkin verfasserin aut Jane A. Grasby verfasserin aut John A. Tainer verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:15 https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260 kostenfrei https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 15
allfields_unstemmed	10.1038/ncomms15855 doi (DE-627)DOAJ048299057 (DE-599)DOAJ7d8f8666ae664b27be8155fb17c1e260 DE-627 ger DE-627 rakwb eng Susan E. Tsutakawa verfasserin aut Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’. Science Q Mark J. Thompson verfasserin aut Andrew S. Arvai verfasserin aut Alexander J. Neil verfasserin aut Steven J. Shaw verfasserin aut Sana I. Algasaier verfasserin aut Jane C. Kim verfasserin aut L. David Finger verfasserin aut Emma Jardine verfasserin aut Victoria J.B. Gotham verfasserin aut Altaf H. Sarker verfasserin aut Mai Z. Her verfasserin aut Fahad Rashid verfasserin aut Samir M. Hamdan verfasserin aut Sergei M. Mirkin verfasserin aut Jane A. Grasby verfasserin aut John A. Tainer verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:15 https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260 kostenfrei https://doi.org/10.1038/ncomms15855 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 15
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author	Susan E. Tsutakawa
spellingShingle	Susan E. Tsutakawa misc Science misc Q Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
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topic_title	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
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title	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
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title_full	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
author_sort	Susan E. Tsutakawa
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author_browse	Susan E. Tsutakawa Mark J. Thompson Andrew S. Arvai Alexander J. Neil Steven J. Shaw Sana I. Algasaier Jane C. Kim L. David Finger Emma Jardine Victoria J.B. Gotham Altaf H. Sarker Mai Z. Her Fahad Rashid Samir M. Hamdan Sergei M. Mirkin Jane A. Grasby John A. Tainer
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title_sort	phosphate steering by flap endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_auth	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
abstract	Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.
abstractGer	Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.
abstract_unstemmed	Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.
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title_short	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
url	https://doi.org/10.1038/ncomms15855 https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260 https://doaj.org/toc/2041-1723
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up_date	2024-07-03T17:01:06.126Z
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