Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets
Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the...
Ausführliche Beschreibung
Autor*in: |
Felicity Newell [verfasserIn] Yan Kong [verfasserIn] James S. Wilmott [verfasserIn] Peter A. Johansson [verfasserIn] Peter M. Ferguson [verfasserIn] Chuanliang Cui [verfasserIn] Zhongwu Li [verfasserIn] Stephen H. Kazakoff [verfasserIn] Hazel Burke [verfasserIn] Tristan J. Dodds [verfasserIn] Ann-Marie Patch [verfasserIn] Katia Nones [verfasserIn] Varsha Tembe [verfasserIn] Ping Shang [verfasserIn] Louise van der Weyden [verfasserIn] Kim Wong [verfasserIn] Oliver Holmes [verfasserIn] Serigne Lo [verfasserIn] Conrad Leonard [verfasserIn] Scott Wood [verfasserIn] Qinying Xu [verfasserIn] Robert V. Rawson [verfasserIn] Pamela Mukhopadhyay [verfasserIn] Reinhard Dummer [verfasserIn] Mitchell P. Levesque [verfasserIn] Göran Jönsson [verfasserIn] Xuan Wang [verfasserIn] Iwei Yeh [verfasserIn] Hong Wu [verfasserIn] Nancy Joseph [verfasserIn] Boris C. Bastian [verfasserIn] Georgina V. Long [verfasserIn] Andrew J. Spillane [verfasserIn] Kerwin F. Shannon [verfasserIn] John F. Thompson [verfasserIn] Robyn P. M. Saw [verfasserIn] David J. Adams [verfasserIn] Lu Si [verfasserIn] John V. Pearson [verfasserIn] Nicholas K. Hayward [verfasserIn] Nicola Waddell [verfasserIn] Graham J. Mann [verfasserIn] Jun Guo [verfasserIn] Richard A. Scolyer [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 15 |
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Übergeordnetes Werk: |
volume:10 ; year:2019 ; number:1 ; pages:15 |
Links: |
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DOI / URN: |
10.1038/s41467-019-11107-x |
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Katalog-ID: |
DOAJ048311871 |
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10.1038/s41467-019-11107-x doi (DE-627)DOAJ048311871 (DE-599)DOAJ2e6c660727314c7ebfed4a9f82ef05a8 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. Science Q Yan Kong verfasserin aut James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Peter M. Ferguson verfasserin aut Chuanliang Cui verfasserin aut Zhongwu Li verfasserin aut Stephen H. Kazakoff verfasserin aut Hazel Burke verfasserin aut Tristan J. Dodds verfasserin aut Ann-Marie Patch verfasserin aut Katia Nones verfasserin aut Varsha Tembe verfasserin aut Ping Shang verfasserin aut Louise van der Weyden verfasserin aut Kim Wong verfasserin aut Oliver Holmes verfasserin aut Serigne Lo verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Qinying Xu verfasserin aut Robert V. Rawson verfasserin aut Pamela Mukhopadhyay verfasserin aut Reinhard Dummer verfasserin aut Mitchell P. Levesque verfasserin aut Göran Jönsson verfasserin aut Xuan Wang verfasserin aut Iwei Yeh verfasserin aut Hong Wu verfasserin aut Nancy Joseph verfasserin aut Boris C. Bastian verfasserin aut Georgina V. Long verfasserin aut Andrew J. Spillane verfasserin aut Kerwin F. Shannon verfasserin aut John F. Thompson verfasserin aut Robyn P. M. Saw verfasserin aut David J. Adams verfasserin aut Lu Si verfasserin aut John V. Pearson verfasserin aut Nicholas K. Hayward verfasserin aut Nicola Waddell verfasserin aut Graham J. Mann verfasserin aut Jun Guo verfasserin aut Richard A. Scolyer verfasserin aut In Nature Communications Nature Portfolio, 2016 10(2019), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:10 year:2019 number:1 pages:15 https://doi.org/10.1038/s41467-019-11107-x kostenfrei https://doaj.org/article/2e6c660727314c7ebfed4a9f82ef05a8 kostenfrei https://doi.org/10.1038/s41467-019-11107-x kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 1 15 |
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10.1038/s41467-019-11107-x doi (DE-627)DOAJ048311871 (DE-599)DOAJ2e6c660727314c7ebfed4a9f82ef05a8 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. Science Q Yan Kong verfasserin aut James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Peter M. Ferguson verfasserin aut Chuanliang Cui verfasserin aut Zhongwu Li verfasserin aut Stephen H. Kazakoff verfasserin aut Hazel Burke verfasserin aut Tristan J. Dodds verfasserin aut Ann-Marie Patch verfasserin aut Katia Nones verfasserin aut Varsha Tembe verfasserin aut Ping Shang verfasserin aut Louise van der Weyden verfasserin aut Kim Wong verfasserin aut Oliver Holmes verfasserin aut Serigne Lo verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Qinying Xu verfasserin aut Robert V. Rawson verfasserin aut Pamela Mukhopadhyay verfasserin aut Reinhard Dummer verfasserin aut Mitchell P. Levesque verfasserin aut Göran Jönsson verfasserin aut Xuan Wang verfasserin aut Iwei Yeh verfasserin aut Hong Wu verfasserin aut Nancy Joseph verfasserin aut Boris C. Bastian verfasserin aut Georgina V. Long verfasserin aut Andrew J. Spillane verfasserin aut Kerwin F. Shannon verfasserin aut John F. Thompson verfasserin aut Robyn P. M. Saw verfasserin aut David J. Adams verfasserin aut Lu Si verfasserin aut John V. Pearson verfasserin aut Nicholas K. Hayward verfasserin aut Nicola Waddell verfasserin aut Graham J. Mann verfasserin aut Jun Guo verfasserin aut Richard A. Scolyer verfasserin aut In Nature Communications Nature Portfolio, 2016 10(2019), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:10 year:2019 number:1 pages:15 https://doi.org/10.1038/s41467-019-11107-x kostenfrei https://doaj.org/article/2e6c660727314c7ebfed4a9f82ef05a8 kostenfrei https://doi.org/10.1038/s41467-019-11107-x kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 1 15 |
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Felicity Newell @@aut@@ Yan Kong @@aut@@ James S. Wilmott @@aut@@ Peter A. Johansson @@aut@@ Peter M. Ferguson @@aut@@ Chuanliang Cui @@aut@@ Zhongwu Li @@aut@@ Stephen H. Kazakoff @@aut@@ Hazel Burke @@aut@@ Tristan J. Dodds @@aut@@ Ann-Marie Patch @@aut@@ Katia Nones @@aut@@ Varsha Tembe @@aut@@ Ping Shang @@aut@@ Louise van der Weyden @@aut@@ Kim Wong @@aut@@ Oliver Holmes @@aut@@ Serigne Lo @@aut@@ Conrad Leonard @@aut@@ Scott Wood @@aut@@ Qinying Xu @@aut@@ Robert V. Rawson @@aut@@ Pamela Mukhopadhyay @@aut@@ Reinhard Dummer @@aut@@ Mitchell P. Levesque @@aut@@ Göran Jönsson @@aut@@ Xuan Wang @@aut@@ Iwei Yeh @@aut@@ Hong Wu @@aut@@ Nancy Joseph @@aut@@ Boris C. Bastian @@aut@@ Georgina V. Long @@aut@@ Andrew J. Spillane @@aut@@ Kerwin F. Shannon @@aut@@ John F. Thompson @@aut@@ Robyn P. M. Saw @@aut@@ David J. Adams @@aut@@ Lu Si @@aut@@ John V. Pearson @@aut@@ Nicholas K. Hayward @@aut@@ Nicola Waddell @@aut@@ Graham J. Mann @@aut@@ Jun Guo @@aut@@ Richard A. Scolyer @@aut@@ |
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Felicity Newell Yan Kong James S. Wilmott Peter A. Johansson Peter M. Ferguson Chuanliang Cui Zhongwu Li Stephen H. Kazakoff Hazel Burke Tristan J. Dodds Ann-Marie Patch Katia Nones Varsha Tembe Ping Shang Louise van der Weyden Kim Wong Oliver Holmes Serigne Lo Conrad Leonard Scott Wood Qinying Xu Robert V. Rawson Pamela Mukhopadhyay Reinhard Dummer Mitchell P. Levesque Göran Jönsson Xuan Wang Iwei Yeh Hong Wu Nancy Joseph Boris C. Bastian Georgina V. Long Andrew J. Spillane Kerwin F. Shannon John F. Thompson Robyn P. M. Saw David J. Adams Lu Si John V. Pearson Nicholas K. Hayward Nicola Waddell Graham J. Mann Jun Guo Richard A. Scolyer |
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whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets |
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Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. |
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Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. |
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Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease. |
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