Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer
Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Maria Sofia Cattaruzza [verfasserIn] Vincenzo Zagà [verfasserIn] Roberta Pacifici [verfasserIn] Paola Martucci [verfasserIn] Rocco Trisolini [verfasserIn] Paolo Bartolomei [verfasserIn] Massimo Esposito [verfasserIn] Rafaela Giacobbe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
In: Tobacco Prevention and Cessation - European Publishing, 2017, 5(2019), Supplement |
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| Übergeordnetes Werk: |
volume:5 ; year:2019 ; number:Supplement |
| Links: |
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| DOI / URN: |
10.18332/tpc/105295 |
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| Katalog-ID: |
DOAJ048356247 |
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| 520 | |a Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. | ||
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10.18332/tpc/105295 doi (DE-627)DOAJ048356247 (DE-599)DOAJc53f26fee45241d787e663233d611a74 DE-627 ger DE-627 rakwb eng RA1-1270 Maria Sofia Cattaruzza verfasserin aut Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. polonium smokers ex-smokers non-smokers lung cancer Public aspects of medicine Vincenzo Zagà verfasserin aut Roberta Pacifici verfasserin aut Paola Martucci verfasserin aut Rocco Trisolini verfasserin aut Paolo Bartolomei verfasserin aut Massimo Esposito verfasserin aut Rafaela Giacobbe verfasserin aut In Tobacco Prevention and Cessation European Publishing, 2017 5(2019), Supplement (DE-627)174397759X 24593087 nnns volume:5 year:2019 number:Supplement https://doi.org/10.18332/tpc/105295 kostenfrei https://doaj.org/article/c53f26fee45241d787e663233d611a74 kostenfrei https://www.tobaccopreventioncessation.com/Polonium-in-bronchial-washing-specimens-of-smoker-ex-smoker-and-non-smoker-patients,105295,0,2.html kostenfrei https://doaj.org/toc/2459-3087 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 5 2019 Supplement |
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10.18332/tpc/105295 doi (DE-627)DOAJ048356247 (DE-599)DOAJc53f26fee45241d787e663233d611a74 DE-627 ger DE-627 rakwb eng RA1-1270 Maria Sofia Cattaruzza verfasserin aut Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. polonium smokers ex-smokers non-smokers lung cancer Public aspects of medicine Vincenzo Zagà verfasserin aut Roberta Pacifici verfasserin aut Paola Martucci verfasserin aut Rocco Trisolini verfasserin aut Paolo Bartolomei verfasserin aut Massimo Esposito verfasserin aut Rafaela Giacobbe verfasserin aut In Tobacco Prevention and Cessation European Publishing, 2017 5(2019), Supplement (DE-627)174397759X 24593087 nnns volume:5 year:2019 number:Supplement https://doi.org/10.18332/tpc/105295 kostenfrei https://doaj.org/article/c53f26fee45241d787e663233d611a74 kostenfrei https://www.tobaccopreventioncessation.com/Polonium-in-bronchial-washing-specimens-of-smoker-ex-smoker-and-non-smoker-patients,105295,0,2.html kostenfrei https://doaj.org/toc/2459-3087 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 5 2019 Supplement |
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10.18332/tpc/105295 doi (DE-627)DOAJ048356247 (DE-599)DOAJc53f26fee45241d787e663233d611a74 DE-627 ger DE-627 rakwb eng RA1-1270 Maria Sofia Cattaruzza verfasserin aut Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. polonium smokers ex-smokers non-smokers lung cancer Public aspects of medicine Vincenzo Zagà verfasserin aut Roberta Pacifici verfasserin aut Paola Martucci verfasserin aut Rocco Trisolini verfasserin aut Paolo Bartolomei verfasserin aut Massimo Esposito verfasserin aut Rafaela Giacobbe verfasserin aut In Tobacco Prevention and Cessation European Publishing, 2017 5(2019), Supplement (DE-627)174397759X 24593087 nnns volume:5 year:2019 number:Supplement https://doi.org/10.18332/tpc/105295 kostenfrei https://doaj.org/article/c53f26fee45241d787e663233d611a74 kostenfrei https://www.tobaccopreventioncessation.com/Polonium-in-bronchial-washing-specimens-of-smoker-ex-smoker-and-non-smoker-patients,105295,0,2.html kostenfrei https://doaj.org/toc/2459-3087 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 5 2019 Supplement |
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10.18332/tpc/105295 doi (DE-627)DOAJ048356247 (DE-599)DOAJc53f26fee45241d787e663233d611a74 DE-627 ger DE-627 rakwb eng RA1-1270 Maria Sofia Cattaruzza verfasserin aut Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. polonium smokers ex-smokers non-smokers lung cancer Public aspects of medicine Vincenzo Zagà verfasserin aut Roberta Pacifici verfasserin aut Paola Martucci verfasserin aut Rocco Trisolini verfasserin aut Paolo Bartolomei verfasserin aut Massimo Esposito verfasserin aut Rafaela Giacobbe verfasserin aut In Tobacco Prevention and Cessation European Publishing, 2017 5(2019), Supplement (DE-627)174397759X 24593087 nnns volume:5 year:2019 number:Supplement https://doi.org/10.18332/tpc/105295 kostenfrei https://doaj.org/article/c53f26fee45241d787e663233d611a74 kostenfrei https://www.tobaccopreventioncessation.com/Polonium-in-bronchial-washing-specimens-of-smoker-ex-smoker-and-non-smoker-patients,105295,0,2.html kostenfrei https://doaj.org/toc/2459-3087 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 5 2019 Supplement |
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10.18332/tpc/105295 doi (DE-627)DOAJ048356247 (DE-599)DOAJc53f26fee45241d787e663233d611a74 DE-627 ger DE-627 rakwb eng RA1-1270 Maria Sofia Cattaruzza verfasserin aut Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. polonium smokers ex-smokers non-smokers lung cancer Public aspects of medicine Vincenzo Zagà verfasserin aut Roberta Pacifici verfasserin aut Paola Martucci verfasserin aut Rocco Trisolini verfasserin aut Paolo Bartolomei verfasserin aut Massimo Esposito verfasserin aut Rafaela Giacobbe verfasserin aut In Tobacco Prevention and Cessation European Publishing, 2017 5(2019), Supplement (DE-627)174397759X 24593087 nnns volume:5 year:2019 number:Supplement https://doi.org/10.18332/tpc/105295 kostenfrei https://doaj.org/article/c53f26fee45241d787e663233d611a74 kostenfrei https://www.tobaccopreventioncessation.com/Polonium-in-bronchial-washing-specimens-of-smoker-ex-smoker-and-non-smoker-patients,105295,0,2.html kostenfrei https://doaj.org/toc/2459-3087 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 5 2019 Supplement |
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Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. 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Maria Sofia Cattaruzza |
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polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer |
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Polonium in bronchial washing specimens of smoker, ex-smoker and non-smoker patients with lung cancer |
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Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. |
| abstractGer |
Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. |
| abstract_unstemmed |
Introduction The aim of this study was to verify the presence of radioactive Polonium (Po-210) in the lungs of patients with lung cancer who were smokers, ex-smokers and never-smokers. Methods Bronchial washing specimens of 55 patients diagnosed with non-microcytoma lung cancer (NSCLC), underwent alpha spectrometric analysis in order to detect the presence of Polonium 210 (Po-210) (primary end point). Patients were divided into 3 arms (smokers, ex-smokers, never-smokers). The detection of alpha radioactivity in urine and the detection of spirometric data were also performed (secondary end points). Each patient was then given a kit for the detection of the environmental Radon at home (for 3 months). Results 67 Bronchial washings were examined: 22 of smokers, 35 of ex-smokers and 10 of never-smokers. The Polonium was detected in 100% of the current smokers (mean 6 mBq) and of the ex-smokers (mean 4 mBq) bronchial washings, while it was detected only in 60% of the never-smokers bronchial washings. It is interesting that ex- smokers had quit smoking for at least 5 years. There were even 3 patients who quit 11, 17 and 20 years before. All patients presented a picture of chronic bronchitis or had a spirometry that could be classified as stage I or II GOLD. This suggests that heavy metal retention is more a function of mucociliary clearance than bronchial obstruction. Conclusion The presence of Po-210 in the ex-smoker bronchial washings is an important finding both for understanding lung carcinogenesis and for health education and therapeutic recommendations. |
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Vincenzo Zagà Roberta Pacifici Paola Martucci Rocco Trisolini Paolo Bartolomei Massimo Esposito Rafaela Giacobbe |
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