MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1

Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However,...
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Autor*in:	He X [verfasserIn] Wei Y [verfasserIn] Wang Y [verfasserIn] Liu L [verfasserIn] Wang W [verfasserIn] Li N [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT)

Übergeordnetes Werk:	In: OncoTargets and Therapy - Dove Medical Press, 2009, (2016), Issue 1, Seite 1231-1239
Übergeordnetes Werk:	year:2016 ; number:Issue 1 ; pages:1231-1239

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ048405108

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520			\|a Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT
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allfields	(DE-627)DOAJ048405108 (DE-599)DOAJ5886353ccf374dee82fe567013dfddb2 DE-627 ger DE-627 rakwb eng RC254-282 He X verfasserin aut MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wei Y verfasserin aut Wang Y verfasserin aut Liu L verfasserin aut Wang W verfasserin aut Li N verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Issue 1, Seite 1231-1239 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 number:Issue 1 pages:1231-1239 https://doaj.org/article/5886353ccf374dee82fe567013dfddb2 kostenfrei https://www.dovepress.com/mir-381-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-target-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 Issue 1 1231-1239
spelling	(DE-627)DOAJ048405108 (DE-599)DOAJ5886353ccf374dee82fe567013dfddb2 DE-627 ger DE-627 rakwb eng RC254-282 He X verfasserin aut MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wei Y verfasserin aut Wang Y verfasserin aut Liu L verfasserin aut Wang W verfasserin aut Li N verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Issue 1, Seite 1231-1239 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 number:Issue 1 pages:1231-1239 https://doaj.org/article/5886353ccf374dee82fe567013dfddb2 kostenfrei https://www.dovepress.com/mir-381-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-target-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 Issue 1 1231-1239
allfields_unstemmed	(DE-627)DOAJ048405108 (DE-599)DOAJ5886353ccf374dee82fe567013dfddb2 DE-627 ger DE-627 rakwb eng RC254-282 He X verfasserin aut MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wei Y verfasserin aut Wang Y verfasserin aut Liu L verfasserin aut Wang W verfasserin aut Li N verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Issue 1, Seite 1231-1239 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 number:Issue 1 pages:1231-1239 https://doaj.org/article/5886353ccf374dee82fe567013dfddb2 kostenfrei https://www.dovepress.com/mir-381-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-target-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 Issue 1 1231-1239
allfieldsGer	(DE-627)DOAJ048405108 (DE-599)DOAJ5886353ccf374dee82fe567013dfddb2 DE-627 ger DE-627 rakwb eng RC254-282 He X verfasserin aut MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wei Y verfasserin aut Wang Y verfasserin aut Liu L verfasserin aut Wang W verfasserin aut Li N verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Issue 1, Seite 1231-1239 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 number:Issue 1 pages:1231-1239 https://doaj.org/article/5886353ccf374dee82fe567013dfddb2 kostenfrei https://www.dovepress.com/mir-381-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-target-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 Issue 1 1231-1239
allfieldsSound	(DE-627)DOAJ048405108 (DE-599)DOAJ5886353ccf374dee82fe567013dfddb2 DE-627 ger DE-627 rakwb eng RC254-282 He X verfasserin aut MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wei Y verfasserin aut Wang Y verfasserin aut Liu L verfasserin aut Wang W verfasserin aut Li N verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Issue 1, Seite 1231-1239 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 number:Issue 1 pages:1231-1239 https://doaj.org/article/5886353ccf374dee82fe567013dfddb2 kostenfrei https://www.dovepress.com/mir-381-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-target-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 Issue 1 1231-1239
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callnumber-first	R - Medicine
author	He X
spellingShingle	He X misc RC254-282 misc colorectal cancer misc miR-381 misc twist family bHLH transcription factor 1(Twist1) misc cell migration misc invasion misc epithelial-mesenchymal transition (EMT) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1
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topic_title	RC254-282 MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1 colorectal cancer miR-381 twist family bHLH transcription factor 1(Twist1) cell migration invasion epithelial-mesenchymal transition (EMT)
topic	misc RC254-282 misc colorectal cancer misc miR-381 misc twist family bHLH transcription factor 1(Twist1) misc cell migration misc invasion misc epithelial-mesenchymal transition (EMT) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc colorectal cancer misc miR-381 misc twist family bHLH transcription factor 1(Twist1) misc cell migration misc invasion misc epithelial-mesenchymal transition (EMT) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc colorectal cancer misc miR-381 misc twist family bHLH transcription factor 1(Twist1) misc cell migration misc invasion misc epithelial-mesenchymal transition (EMT) misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1
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title_full	MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1
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title_sort	mir-381 functions as a tumor suppressor in colorectal cancer by targeting twist1
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title_auth	MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1
abstract	Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT
abstractGer	Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT
abstract_unstemmed	Xinxin He, Yangnian Wei, Yong Wang, Ling Liu, Wen Wang, Nianfeng Li Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Hunan, People’s Republic of China Abstract: MiR-381 has been reported to be dysregulated in several human cancers. However, the function and mechanism of miR-381 in colorectal cancer (CRC) remains unclear. In the present study, the miR-381 expression was assessed in a cohort of 113 CRC specimens using real-time quantitative polymerase chain reaction (RTq-PCR), which demonstrated that miR-381 was significantly downregulated in CRC and correlated with distant metastasis and tumor, node, and metastasis (TNM) stage. Functional study revealed that restoration of miR-381 significantly inhibited the invasion, migration, and epithelial–mesenchymal transition (EMT) of CRC cells. Luciferase reporter assay validated that Twist1, an important EMT inducer, was a direct target of miR-381, and rescued Twist1 attenuated the function of miR-381 in CRC cells. Correlation analysis also revealed an inverse correlation between miR-381 and Twist1 expression levels in CRC specimens. Taken together, our results highlight the significance of miR-381/Twist1 interaction in the development and progression of CRC, and suggest that restoration of miR-381 may be a potential therapeutic strategy for the patients with CRC. Keywords: colorectal cancer, miR-381, twist family bHLH transcription factor 1, Twist1, epithelial–mesenchymal transition, EMT
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title_short	MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1
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up_date	2024-07-03T17:36:52.470Z
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MiR-381 functions as a tumor suppressor in colorectal cancer by targeting Twist1

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