Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients

Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs273610...
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Gespeichert in:

Autor*in:	Enrica Rampazzo [verfasserIn] Erika Cecchin [verfasserIn] Paola Del Bianco [verfasserIn] Chiara Menin [verfasserIn] Gaya Spolverato [verfasserIn] Silvia Giunco [verfasserIn] Sara Lonardi [verfasserIn] Sandro Malacrida [verfasserIn] Antonino De Paoli [verfasserIn] Giuseppe Toffoli [verfasserIn] Salvatore Pucciarelli [verfasserIn] Anita De Rossi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	TERT telomerase SNPs variants telomere length circulating

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 11, p 3115
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:11, p 3115

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12113115

Katalog-ID:	DOAJ048582808

Internformat


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520			\|a Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients.
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allfields	10.3390/cancers12113115 doi (DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47 DE-627 ger DE-627 rakwb eng RC254-282 Enrica Rampazzo verfasserin aut Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients. TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erika Cecchin verfasserin aut Paola Del Bianco verfasserin aut Chiara Menin verfasserin aut Gaya Spolverato verfasserin aut Silvia Giunco verfasserin aut Sara Lonardi verfasserin aut Sandro Malacrida verfasserin aut Antonino De Paoli verfasserin aut Giuseppe Toffoli verfasserin aut Salvatore Pucciarelli verfasserin aut Anita De Rossi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 11, p 3115 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:11, p 3115 https://doi.org/10.3390/cancers12113115 kostenfrei https://doaj.org/article/fdcfc9849adb4991ae00aeefbc1f2d47 kostenfrei https://www.mdpi.com/2072-6694/12/11/3115 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 11, p 3115
spelling	10.3390/cancers12113115 doi (DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47 DE-627 ger DE-627 rakwb eng RC254-282 Enrica Rampazzo verfasserin aut Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients. TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erika Cecchin verfasserin aut Paola Del Bianco verfasserin aut Chiara Menin verfasserin aut Gaya Spolverato verfasserin aut Silvia Giunco verfasserin aut Sara Lonardi verfasserin aut Sandro Malacrida verfasserin aut Antonino De Paoli verfasserin aut Giuseppe Toffoli verfasserin aut Salvatore Pucciarelli verfasserin aut Anita De Rossi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 11, p 3115 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:11, p 3115 https://doi.org/10.3390/cancers12113115 kostenfrei https://doaj.org/article/fdcfc9849adb4991ae00aeefbc1f2d47 kostenfrei https://www.mdpi.com/2072-6694/12/11/3115 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 11, p 3115
allfields_unstemmed	10.3390/cancers12113115 doi (DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47 DE-627 ger DE-627 rakwb eng RC254-282 Enrica Rampazzo verfasserin aut Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients. TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erika Cecchin verfasserin aut Paola Del Bianco verfasserin aut Chiara Menin verfasserin aut Gaya Spolverato verfasserin aut Silvia Giunco verfasserin aut Sara Lonardi verfasserin aut Sandro Malacrida verfasserin aut Antonino De Paoli verfasserin aut Giuseppe Toffoli verfasserin aut Salvatore Pucciarelli verfasserin aut Anita De Rossi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 11, p 3115 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:11, p 3115 https://doi.org/10.3390/cancers12113115 kostenfrei https://doaj.org/article/fdcfc9849adb4991ae00aeefbc1f2d47 kostenfrei https://www.mdpi.com/2072-6694/12/11/3115 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 11, p 3115
allfieldsGer	10.3390/cancers12113115 doi (DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47 DE-627 ger DE-627 rakwb eng RC254-282 Enrica Rampazzo verfasserin aut Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients. TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erika Cecchin verfasserin aut Paola Del Bianco verfasserin aut Chiara Menin verfasserin aut Gaya Spolverato verfasserin aut Silvia Giunco verfasserin aut Sara Lonardi verfasserin aut Sandro Malacrida verfasserin aut Antonino De Paoli verfasserin aut Giuseppe Toffoli verfasserin aut Salvatore Pucciarelli verfasserin aut Anita De Rossi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 11, p 3115 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:11, p 3115 https://doi.org/10.3390/cancers12113115 kostenfrei https://doaj.org/article/fdcfc9849adb4991ae00aeefbc1f2d47 kostenfrei https://www.mdpi.com/2072-6694/12/11/3115 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 11, p 3115
allfieldsSound	10.3390/cancers12113115 doi (DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47 DE-627 ger DE-627 rakwb eng RC254-282 Enrica Rampazzo verfasserin aut Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients. TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erika Cecchin verfasserin aut Paola Del Bianco verfasserin aut Chiara Menin verfasserin aut Gaya Spolverato verfasserin aut Silvia Giunco verfasserin aut Sara Lonardi verfasserin aut Sandro Malacrida verfasserin aut Antonino De Paoli verfasserin aut Giuseppe Toffoli verfasserin aut Salvatore Pucciarelli verfasserin aut Anita De Rossi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 11, p 3115 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:11, p 3115 https://doi.org/10.3390/cancers12113115 kostenfrei https://doaj.org/article/fdcfc9849adb4991ae00aeefbc1f2d47 kostenfrei https://www.mdpi.com/2072-6694/12/11/3115 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 11, p 3115
language	English
source	In Cancers 12(2020), 11, p 3115 volume:12 year:2020 number:11, p 3115
sourceStr	In Cancers 12(2020), 11, p 3115 volume:12 year:2020 number:11, p 3115
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Enrica Rampazzo @@aut@@ Erika Cecchin @@aut@@ Paola Del Bianco @@aut@@ Chiara Menin @@aut@@ Gaya Spolverato @@aut@@ Silvia Giunco @@aut@@ Sara Lonardi @@aut@@ Sandro Malacrida @@aut@@ Antonino De Paoli @@aut@@ Giuseppe Toffoli @@aut@@ Salvatore Pucciarelli @@aut@@ Anita De Rossi @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ048582808
language_de	englisch
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callnumber-first	R - Medicine
author	Enrica Rampazzo
spellingShingle	Enrica Rampazzo misc RC254-282 misc TERT misc telomerase misc SNPs misc variants misc telomere length misc circulating <i<TERT</i< mRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients
authorStr	Enrica Rampazzo
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topic_title	RC254-282 Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients TERT telomerase SNPs variants telomere length circulating <i<TERT</i< mRNA
topic	misc RC254-282 misc TERT misc telomerase misc SNPs misc variants misc telomere length misc circulating <i<TERT</i< mRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc TERT misc telomerase misc SNPs misc variants misc telomere length misc circulating <i<TERT</i< mRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc TERT misc telomerase misc SNPs misc variants misc telomere length misc circulating <i<TERT</i< mRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients
ctrlnum	(DE-627)DOAJ048582808 (DE-599)DOAJfdcfc9849adb4991ae00aeefbc1f2d47
title_full	Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients
author_sort	Enrica Rampazzo
journal	Cancers
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author_browse	Enrica Rampazzo Erika Cecchin Paola Del Bianco Chiara Menin Gaya Spolverato Silvia Giunco Sara Lonardi Sandro Malacrida Antonino De Paoli Giuseppe Toffoli Salvatore Pucciarelli Anita De Rossi
container_volume	12
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Enrica Rampazzo
doi_str_mv	10.3390/cancers12113115
author2-role	verfasserin
title_sort	genetic variants of the <i<tert</i< gene, telomere length, and circulating <i<tert</i< as prognostic markers in rectal cancer patients
callnumber	RC254-282
title_auth	Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients
abstract	Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients.
abstractGer	Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients.
abstract_unstemmed	Single-nucleotide polymorphisms (SNPs) in the <i<TERT</i< gene can affect telomere length and <i<TERT</i< expression and have been associated with risk and/or outcome for several tumors, but very few data are available about their impact on rectal cancer. Eight SNPs (rs2736108, rs2735940, rs2736098, rs2736100, rs35241335, rs11742908, rs2736122 and rs2853690), mapping in regulatory and coding regions of the <i<TERT</i< gene, were studied in 194 rectal cancer patients to evaluate their association with constitutive telomere length, circulating <i<TERT</i< mRNA levels, response to neoadjuvant chemoradiotherapy (CRT) and disease outcome. At diagnosis, the rs2736100CC genotype was associated with longer telomeres measured pre-CRT, while the rs2736100CC, rs2736108TT and rs2735940AA were associated with greater telomere erosion evaluated post-CRT. The rs2736108CC and rs2853690AA/GG genotypes, respectively associated with lower telomere erosion and lower levels of circulating <i<TERT</i< post-CRT, were also independently associated with a better response to therapy [OR 4.6(1.1–19.1) and 3.0(1.3–6.9)]. Overall, post-CRT, low levels (≤ median value) of circulating <i<TERT</i< and its stable/decreasing levels compared to those pre-CRT, were independently associated with a better response to therapy [OR 5.8(1.9–17.8) and 5.3(1.4–19.4), respectively]. Furthermore, post-CRT, patients with long telomeres (<median value) and low levels of circulating <i<TERT</i< had a significantly lower risk of disease progression [HR 0.4(0.1–0.9) and 0.3(0.1–0.8), respectively]. These findings suggest that <i<TERT</i< SNPs could be a useful tool for improving the selection of patients who could benefit from CRT and support the role of telomere length and circulating <i<TERT</i< mRNA levels as useful markers for monitoring the response to therapy and disease outcome in rectal cancer patients.
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title_short	Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients
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Genetic Variants of the <i<TERT</i< Gene, Telomere Length, and Circulating <i<TERT</i< as Prognostic Markers in Rectal Cancer Patients

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