Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats

<i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including col...
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Autor*in:	Yong Sun [verfasserIn] Fanghua Guo [verfasserIn] Xin Peng [verfasserIn] Kejun Cheng [verfasserIn] Lu Xiao [verfasserIn] Hua Zhang [verfasserIn] Hongyan Li [verfasserIn] Li Jiang [verfasserIn] Zeyuan Deng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	colonic fermentation phenolics antioxidant capacity bioavailability

Übergeordnetes Werk:	In: Foods - MDPI AG, 2013, 10(2021), 9, p 2123
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:9, p 2123

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/foods10092123

Katalog-ID:	DOAJ048608238

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allfields	10.3390/foods10092123 doi (DE-627)DOAJ048608238 (DE-599)DOAJ05c57cbd87d64f1bb05895e672e264b1 DE-627 ger DE-627 rakwb eng TP1-1185 Yong Sun verfasserin aut Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food. <i<Radix Tetrastigma</i< colonic fermentation phenolics antioxidant capacity bioavailability Chemical technology Fanghua Guo verfasserin aut Xin Peng verfasserin aut Kejun Cheng verfasserin aut Lu Xiao verfasserin aut Hua Zhang verfasserin aut Hongyan Li verfasserin aut Li Jiang verfasserin aut Zeyuan Deng verfasserin aut In Foods MDPI AG, 2013 10(2021), 9, p 2123 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:10 year:2021 number:9, p 2123 https://doi.org/10.3390/foods10092123 kostenfrei https://doaj.org/article/05c57cbd87d64f1bb05895e672e264b1 kostenfrei https://www.mdpi.com/2304-8158/10/9/2123 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2123
spelling	10.3390/foods10092123 doi (DE-627)DOAJ048608238 (DE-599)DOAJ05c57cbd87d64f1bb05895e672e264b1 DE-627 ger DE-627 rakwb eng TP1-1185 Yong Sun verfasserin aut Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food. <i<Radix Tetrastigma</i< colonic fermentation phenolics antioxidant capacity bioavailability Chemical technology Fanghua Guo verfasserin aut Xin Peng verfasserin aut Kejun Cheng verfasserin aut Lu Xiao verfasserin aut Hua Zhang verfasserin aut Hongyan Li verfasserin aut Li Jiang verfasserin aut Zeyuan Deng verfasserin aut In Foods MDPI AG, 2013 10(2021), 9, p 2123 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:10 year:2021 number:9, p 2123 https://doi.org/10.3390/foods10092123 kostenfrei https://doaj.org/article/05c57cbd87d64f1bb05895e672e264b1 kostenfrei https://www.mdpi.com/2304-8158/10/9/2123 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2123
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allfieldsGer	10.3390/foods10092123 doi (DE-627)DOAJ048608238 (DE-599)DOAJ05c57cbd87d64f1bb05895e672e264b1 DE-627 ger DE-627 rakwb eng TP1-1185 Yong Sun verfasserin aut Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food. <i<Radix Tetrastigma</i< colonic fermentation phenolics antioxidant capacity bioavailability Chemical technology Fanghua Guo verfasserin aut Xin Peng verfasserin aut Kejun Cheng verfasserin aut Lu Xiao verfasserin aut Hua Zhang verfasserin aut Hongyan Li verfasserin aut Li Jiang verfasserin aut Zeyuan Deng verfasserin aut In Foods MDPI AG, 2013 10(2021), 9, p 2123 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:10 year:2021 number:9, p 2123 https://doi.org/10.3390/foods10092123 kostenfrei https://doaj.org/article/05c57cbd87d64f1bb05895e672e264b1 kostenfrei https://www.mdpi.com/2304-8158/10/9/2123 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2123
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callnumber-first	T - Technology
author	Yong Sun
spellingShingle	Yong Sun misc TP1-1185 misc <i<Radix Tetrastigma</i< misc colonic fermentation misc phenolics misc antioxidant capacity misc bioavailability misc Chemical technology Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats
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topic_title	TP1-1185 Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats <i<Radix Tetrastigma</i< colonic fermentation phenolics antioxidant capacity bioavailability
topic	misc TP1-1185 misc <i<Radix Tetrastigma</i< misc colonic fermentation misc phenolics misc antioxidant capacity misc bioavailability misc Chemical technology
topic_unstemmed	misc TP1-1185 misc <i<Radix Tetrastigma</i< misc colonic fermentation misc phenolics misc antioxidant capacity misc bioavailability misc Chemical technology
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title	Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats
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title_full	Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats
author_sort	Yong Sun
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title_sort	metabolism of phenolics of <i<tetrastigma hemsleyanum</i< roots under in vitro digestion and colonic fermentation as well as their in vivo antioxidant activity in rats
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title_auth	Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats
abstract	<i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food.
abstractGer	<i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food.
abstract_unstemmed	<i<Tetrastigma hemsleyanum</i< Diels et Gilg is a herbaceous perennial species distributed mainly in southern China. The <i<Tetrastigma hemsleyanum</i< root (THR) has been prevalently consumed as a functional tea or dietary supplement. In vitro digestion models, including colonic fermentation, were built to evaluate the release and stability of THR phenolics with the method of HPLC-QqQ-MS/MS and UPLC-Qtof-MS/MS. From the oral cavity, the contents of total phenolic and flavonoid began to degrade. Quercetin-3-rutinoside, quercetin-3-glucoside, kaempferol-3-rutinoside, and kaempferol-3-glucoside were metabolized as major components and they were absorbed in the form of glycosides for hepatic metabolism. On the other hand, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and glutathione (GSH) content were significantly increased, while malondialdehyde (MDA) content was decreased in plasma and tissues of rats treated with THR extract in the oxidative stress model. These results indicated that the THR extract is a good antioxidant substance and has good bioavailability, which can effectively prevent some chronic diseases caused by oxidative stress. It also provides a basis for the effectiveness of THR as a traditional functional food.
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title_short	Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats
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Metabolism of Phenolics of <i<Tetrastigma hemsleyanum</i< Roots under In Vitro Digestion and Colonic Fermentation as Well as Their In Vivo Antioxidant Activity in Rats

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