CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jie Wu [verfasserIn] Lan Li [verfasserIn] Siyi Wu [verfasserIn] Bin Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cmtm family cancer cell cycle egfr emt apoptosis tumor immunity

Übergeordnetes Werk:	In: Cancer Biology & Medicine - China Anti-Cancer Association, 2019, 17(2020), 3, Seite 528-542
Übergeordnetes Werk:	volume:17 ; year:2020 ; number:3 ; pages:528-542

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.20892/j.issn.2095-3941.2020.0032

Katalog-ID:	DOAJ048697974

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520			\|a The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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912			\|a GBV_ILN_647
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author_variant	j w jw l l ll s w sw b x bx
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allfields	10.20892/j.issn.2095-3941.2020.0032 doi (DE-627)DOAJ048697974 (DE-599)DOAJeaffbe2daf734bfbb271c091a8b1ffdd DE-627 ger DE-627 rakwb eng RC254-282 Jie Wu verfasserin aut CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lan Li verfasserin aut Siyi Wu verfasserin aut Bin Xu verfasserin aut In Cancer Biology & Medicine China Anti-Cancer Association, 2019 17(2020), 3, Seite 528-542 (DE-627)72193739X (DE-600)2676322-9 20953941 nnns volume:17 year:2020 number:3 pages:528-542 https://doi.org/10.20892/j.issn.2095-3941.2020.0032 kostenfrei https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd kostenfrei http://www.cancerbiomed.org/index.php/cocr/article/view/1663 kostenfrei https://doaj.org/toc/2095-3941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 3 528-542
spelling	10.20892/j.issn.2095-3941.2020.0032 doi (DE-627)DOAJ048697974 (DE-599)DOAJeaffbe2daf734bfbb271c091a8b1ffdd DE-627 ger DE-627 rakwb eng RC254-282 Jie Wu verfasserin aut CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lan Li verfasserin aut Siyi Wu verfasserin aut Bin Xu verfasserin aut In Cancer Biology & Medicine China Anti-Cancer Association, 2019 17(2020), 3, Seite 528-542 (DE-627)72193739X (DE-600)2676322-9 20953941 nnns volume:17 year:2020 number:3 pages:528-542 https://doi.org/10.20892/j.issn.2095-3941.2020.0032 kostenfrei https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd kostenfrei http://www.cancerbiomed.org/index.php/cocr/article/view/1663 kostenfrei https://doaj.org/toc/2095-3941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 3 528-542
allfields_unstemmed	10.20892/j.issn.2095-3941.2020.0032 doi (DE-627)DOAJ048697974 (DE-599)DOAJeaffbe2daf734bfbb271c091a8b1ffdd DE-627 ger DE-627 rakwb eng RC254-282 Jie Wu verfasserin aut CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lan Li verfasserin aut Siyi Wu verfasserin aut Bin Xu verfasserin aut In Cancer Biology & Medicine China Anti-Cancer Association, 2019 17(2020), 3, Seite 528-542 (DE-627)72193739X (DE-600)2676322-9 20953941 nnns volume:17 year:2020 number:3 pages:528-542 https://doi.org/10.20892/j.issn.2095-3941.2020.0032 kostenfrei https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd kostenfrei http://www.cancerbiomed.org/index.php/cocr/article/view/1663 kostenfrei https://doaj.org/toc/2095-3941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 3 528-542
allfieldsGer	10.20892/j.issn.2095-3941.2020.0032 doi (DE-627)DOAJ048697974 (DE-599)DOAJeaffbe2daf734bfbb271c091a8b1ffdd DE-627 ger DE-627 rakwb eng RC254-282 Jie Wu verfasserin aut CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lan Li verfasserin aut Siyi Wu verfasserin aut Bin Xu verfasserin aut In Cancer Biology & Medicine China Anti-Cancer Association, 2019 17(2020), 3, Seite 528-542 (DE-627)72193739X (DE-600)2676322-9 20953941 nnns volume:17 year:2020 number:3 pages:528-542 https://doi.org/10.20892/j.issn.2095-3941.2020.0032 kostenfrei https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd kostenfrei http://www.cancerbiomed.org/index.php/cocr/article/view/1663 kostenfrei https://doaj.org/toc/2095-3941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 3 528-542
allfieldsSound	10.20892/j.issn.2095-3941.2020.0032 doi (DE-627)DOAJ048697974 (DE-599)DOAJeaffbe2daf734bfbb271c091a8b1ffdd DE-627 ger DE-627 rakwb eng RC254-282 Jie Wu verfasserin aut CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lan Li verfasserin aut Siyi Wu verfasserin aut Bin Xu verfasserin aut In Cancer Biology & Medicine China Anti-Cancer Association, 2019 17(2020), 3, Seite 528-542 (DE-627)72193739X (DE-600)2676322-9 20953941 nnns volume:17 year:2020 number:3 pages:528-542 https://doi.org/10.20892/j.issn.2095-3941.2020.0032 kostenfrei https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd kostenfrei http://www.cancerbiomed.org/index.php/cocr/article/view/1663 kostenfrei https://doaj.org/toc/2095-3941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 3 528-542
language	English
source	In Cancer Biology & Medicine 17(2020), 3, Seite 528-542 volume:17 year:2020 number:3 pages:528-542
sourceStr	In Cancer Biology & Medicine 17(2020), 3, Seite 528-542 volume:17 year:2020 number:3 pages:528-542
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cmtm family cancer cell cycle egfr emt apoptosis tumor immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancer Biology & Medicine
authorswithroles_txt_mv	Jie Wu @@aut@@ Lan Li @@aut@@ Siyi Wu @@aut@@ Bin Xu @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Jie Wu
spellingShingle	Jie Wu misc RC254-282 misc cmtm family misc cancer misc cell cycle misc egfr misc emt misc apoptosis misc tumor immunity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
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topic_title	RC254-282 CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value cmtm family cancer cell cycle egfr emt apoptosis tumor immunity
topic	misc RC254-282 misc cmtm family misc cancer misc cell cycle misc egfr misc emt misc apoptosis misc tumor immunity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc cmtm family misc cancer misc cell cycle misc egfr misc emt misc apoptosis misc tumor immunity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
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title_full	CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
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title_sort	cmtm family proteins 1–8: roles in cancer biological processes and potential clinical value
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title_auth	CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
abstract	The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
abstractGer	The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
abstract_unstemmed	The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
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title_short	CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
url	https://doi.org/10.20892/j.issn.2095-3941.2020.0032 https://doaj.org/article/eaffbe2daf734bfbb271c091a8b1ffdd http://www.cancerbiomed.org/index.php/cocr/article/view/1663 https://doaj.org/toc/2095-3941
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CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

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