Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams
Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reprodu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Karine Maria Boll [verfasserIn] Chiara Cristina Bortolasci [verfasserIn] Tiago Zaminelli [verfasserIn] Luiz Fernando Veríssimo [verfasserIn] André Demambre Bacchi [verfasserIn] Luciana Higachi [verfasserIn] Décio Sabbatini Barbosa [verfasserIn] Estefânia Gastaldello Moreira [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental |
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| Übergeordnetes Werk: |
In: Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo, 2010, 50(2014), 2, Seite 353-359 |
|---|---|
| Übergeordnetes Werk: |
volume:50 ; year:2014 ; number:2 ; pages:353-359 |
| Links: |
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| DOI / URN: |
10.1590/S1984-82502014000200015 |
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| Katalog-ID: |
DOAJ048698504 |
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| 520 | |a Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. | ||
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10.1590/S1984-82502014000200015 doi (DE-627)DOAJ048698504 (DE-599)DOAJbfd7cad554624b7db8a82063b745759c DE-627 ger DE-627 rakwb eng RS1-441 Karine Maria Boll verfasserin aut Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo Pharmacy and materia medica Chiara Cristina Bortolasci verfasserin aut Tiago Zaminelli verfasserin aut Luiz Fernando Veríssimo verfasserin aut André Demambre Bacchi verfasserin aut Luciana Higachi verfasserin aut Décio Sabbatini Barbosa verfasserin aut Estefânia Gastaldello Moreira verfasserin aut In Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo, 2010 50(2014), 2, Seite 353-359 (DE-627)72781057X (DE-600)2685807-1 21759790 nnns volume:50 year:2014 number:2 pages:353-359 https://doi.org/10.1590/S1984-82502014000200015 kostenfrei https://doaj.org/article/bfd7cad554624b7db8a82063b745759c kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en kostenfrei https://doaj.org/toc/2175-9790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2014 2 353-359 |
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10.1590/S1984-82502014000200015 doi (DE-627)DOAJ048698504 (DE-599)DOAJbfd7cad554624b7db8a82063b745759c DE-627 ger DE-627 rakwb eng RS1-441 Karine Maria Boll verfasserin aut Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo Pharmacy and materia medica Chiara Cristina Bortolasci verfasserin aut Tiago Zaminelli verfasserin aut Luiz Fernando Veríssimo verfasserin aut André Demambre Bacchi verfasserin aut Luciana Higachi verfasserin aut Décio Sabbatini Barbosa verfasserin aut Estefânia Gastaldello Moreira verfasserin aut In Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo, 2010 50(2014), 2, Seite 353-359 (DE-627)72781057X (DE-600)2685807-1 21759790 nnns volume:50 year:2014 number:2 pages:353-359 https://doi.org/10.1590/S1984-82502014000200015 kostenfrei https://doaj.org/article/bfd7cad554624b7db8a82063b745759c kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en kostenfrei https://doaj.org/toc/2175-9790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2014 2 353-359 |
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10.1590/S1984-82502014000200015 doi (DE-627)DOAJ048698504 (DE-599)DOAJbfd7cad554624b7db8a82063b745759c DE-627 ger DE-627 rakwb eng RS1-441 Karine Maria Boll verfasserin aut Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo Pharmacy and materia medica Chiara Cristina Bortolasci verfasserin aut Tiago Zaminelli verfasserin aut Luiz Fernando Veríssimo verfasserin aut André Demambre Bacchi verfasserin aut Luciana Higachi verfasserin aut Décio Sabbatini Barbosa verfasserin aut Estefânia Gastaldello Moreira verfasserin aut In Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo, 2010 50(2014), 2, Seite 353-359 (DE-627)72781057X (DE-600)2685807-1 21759790 nnns volume:50 year:2014 number:2 pages:353-359 https://doi.org/10.1590/S1984-82502014000200015 kostenfrei https://doaj.org/article/bfd7cad554624b7db8a82063b745759c kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en kostenfrei https://doaj.org/toc/2175-9790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2014 2 353-359 |
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10.1590/S1984-82502014000200015 doi (DE-627)DOAJ048698504 (DE-599)DOAJbfd7cad554624b7db8a82063b745759c DE-627 ger DE-627 rakwb eng RS1-441 Karine Maria Boll verfasserin aut Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo Pharmacy and materia medica Chiara Cristina Bortolasci verfasserin aut Tiago Zaminelli verfasserin aut Luiz Fernando Veríssimo verfasserin aut André Demambre Bacchi verfasserin aut Luciana Higachi verfasserin aut Décio Sabbatini Barbosa verfasserin aut Estefânia Gastaldello Moreira verfasserin aut In Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo, 2010 50(2014), 2, Seite 353-359 (DE-627)72781057X (DE-600)2685807-1 21759790 nnns volume:50 year:2014 number:2 pages:353-359 https://doi.org/10.1590/S1984-82502014000200015 kostenfrei https://doaj.org/article/bfd7cad554624b7db8a82063b745759c kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en kostenfrei https://doaj.org/toc/2175-9790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2014 2 353-359 |
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10.1590/S1984-82502014000200015 doi (DE-627)DOAJ048698504 (DE-599)DOAJbfd7cad554624b7db8a82063b745759c DE-627 ger DE-627 rakwb eng RS1-441 Karine Maria Boll verfasserin aut Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo Pharmacy and materia medica Chiara Cristina Bortolasci verfasserin aut Tiago Zaminelli verfasserin aut Luiz Fernando Veríssimo verfasserin aut André Demambre Bacchi verfasserin aut Luciana Higachi verfasserin aut Décio Sabbatini Barbosa verfasserin aut Estefânia Gastaldello Moreira verfasserin aut In Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo, 2010 50(2014), 2, Seite 353-359 (DE-627)72781057X (DE-600)2685807-1 21759790 nnns volume:50 year:2014 number:2 pages:353-359 https://doi.org/10.1590/S1984-82502014000200015 kostenfrei https://doaj.org/article/bfd7cad554624b7db8a82063b745759c kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en kostenfrei https://doaj.org/toc/2175-9790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2014 2 353-359 |
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RS1-441 Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams Fitoterápicos/avaliação Passiflora incarnata/uso na gestação Passiflora incarnata/uso na amamentação Passiflora incarnata/toxicidade reprodutiva/estudo experimental Gestação/uso de fitoterápicos Lactação/uso de fitoterápicos Estresse oxidativo |
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Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams |
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Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. |
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Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. |
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Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity. |
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Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams |
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https://doi.org/10.1590/S1984-82502014000200015 https://doaj.org/article/bfd7cad554624b7db8a82063b745759c http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200353&lng=en&tlng=en https://doaj.org/toc/2175-9790 |
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Chiara Cristina Bortolasci Tiago Zaminelli Luiz Fernando Veríssimo André Demambre Bacchi Luciana Higachi Décio Sabbatini Barbosa Estefânia Gastaldello Moreira |
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Chiara Cristina Bortolasci Tiago Zaminelli Luiz Fernando Veríssimo André Demambre Bacchi Luciana Higachi Décio Sabbatini Barbosa Estefânia Gastaldello Moreira |
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RS - Pharmacy |
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10.1590/S1984-82502014000200015 |
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RS1-441 |
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2024-07-03T19:12:20.216Z |
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Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). 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