Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction

Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Katharina A. Mayer [verfasserIn] Johannes Stöckl [verfasserIn] Gerhard J. Zlabinger [verfasserIn] Guido A. Gualdoni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	virus metabolism rhinovirus host-pathogen interaction metabolome

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2019.01533

Katalog-ID:	DOAJ048708240

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allfieldsGer	10.3389/fimmu.2019.01533 doi (DE-627)DOAJ048708240 (DE-599)DOAJ25d72c6976484f14b7dd48094513c95c DE-627 ger DE-627 rakwb eng RC581-607 Katharina A. Mayer verfasserin aut Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of the host according to their specific needs. Technologies for the rigorous analysis of metabolic alterations in cells have recently become widely available and have greatly expanded our knowledge of these crucial host–pathogen interactions. We have learned that most viruses enhance specific anabolic pathways and are highly dependent on these alterations. Since uninfected cells are far more plastic in their metabolism, targeting of the virus-induced metabolic alterations is a promising strategy for specific antiviral therapy and has gained great interest recently. In this review, we summarize the current advances in our understanding of metabolic adaptations during viral infections, with a particular focus on the utilization of this information for therapeutic application. virus metabolism rhinovirus host-pathogen interaction metabolome Immunologic diseases. Allergy Johannes Stöckl verfasserin aut Gerhard J. Zlabinger verfasserin aut Guido A. Gualdoni verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01533 kostenfrei https://doaj.org/article/25d72c6976484f14b7dd48094513c95c kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01533/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfieldsSound	10.3389/fimmu.2019.01533 doi (DE-627)DOAJ048708240 (DE-599)DOAJ25d72c6976484f14b7dd48094513c95c DE-627 ger DE-627 rakwb eng RC581-607 Katharina A. Mayer verfasserin aut Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of the host according to their specific needs. Technologies for the rigorous analysis of metabolic alterations in cells have recently become widely available and have greatly expanded our knowledge of these crucial host–pathogen interactions. We have learned that most viruses enhance specific anabolic pathways and are highly dependent on these alterations. Since uninfected cells are far more plastic in their metabolism, targeting of the virus-induced metabolic alterations is a promising strategy for specific antiviral therapy and has gained great interest recently. In this review, we summarize the current advances in our understanding of metabolic adaptations during viral infections, with a particular focus on the utilization of this information for therapeutic application. virus metabolism rhinovirus host-pathogen interaction metabolome Immunologic diseases. Allergy Johannes Stöckl verfasserin aut Gerhard J. Zlabinger verfasserin aut Guido A. Gualdoni verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01533 kostenfrei https://doaj.org/article/25d72c6976484f14b7dd48094513c95c kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01533/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
language	English
source	In Frontiers in Immunology 10(2019) volume:10 year:2019
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author	Katharina A. Mayer
spellingShingle	Katharina A. Mayer misc RC581-607 misc virus misc metabolism misc rhinovirus misc host-pathogen interaction misc metabolome misc Immunologic diseases. Allergy Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
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topic_title	RC581-607 Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction virus metabolism rhinovirus host-pathogen interaction metabolome
topic	misc RC581-607 misc virus misc metabolism misc rhinovirus misc host-pathogen interaction misc metabolome misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc virus misc metabolism misc rhinovirus misc host-pathogen interaction misc metabolome misc Immunologic diseases. Allergy
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title	Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
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title_sort	hijacking the supplies: metabolism as a novel facet of virus-host interaction
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title_auth	Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
abstract	Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of the host according to their specific needs. Technologies for the rigorous analysis of metabolic alterations in cells have recently become widely available and have greatly expanded our knowledge of these crucial host–pathogen interactions. We have learned that most viruses enhance specific anabolic pathways and are highly dependent on these alterations. Since uninfected cells are far more plastic in their metabolism, targeting of the virus-induced metabolic alterations is a promising strategy for specific antiviral therapy and has gained great interest recently. In this review, we summarize the current advances in our understanding of metabolic adaptations during viral infections, with a particular focus on the utilization of this information for therapeutic application.
abstractGer	Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of the host according to their specific needs. Technologies for the rigorous analysis of metabolic alterations in cells have recently become widely available and have greatly expanded our knowledge of these crucial host–pathogen interactions. We have learned that most viruses enhance specific anabolic pathways and are highly dependent on these alterations. Since uninfected cells are far more plastic in their metabolism, targeting of the virus-induced metabolic alterations is a promising strategy for specific antiviral therapy and has gained great interest recently. In this review, we summarize the current advances in our understanding of metabolic adaptations during viral infections, with a particular focus on the utilization of this information for therapeutic application.
abstract_unstemmed	Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies to shape cellular metabolism and the biosynthesis machinery of the host according to their specific needs. Technologies for the rigorous analysis of metabolic alterations in cells have recently become widely available and have greatly expanded our knowledge of these crucial host–pathogen interactions. We have learned that most viruses enhance specific anabolic pathways and are highly dependent on these alterations. Since uninfected cells are far more plastic in their metabolism, targeting of the virus-induced metabolic alterations is a promising strategy for specific antiviral therapy and has gained great interest recently. In this review, we summarize the current advances in our understanding of metabolic adaptations during viral infections, with a particular focus on the utilization of this information for therapeutic application.
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title_short	Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
url	https://doi.org/10.3389/fimmu.2019.01533 https://doaj.org/article/25d72c6976484f14b7dd48094513c95c https://www.frontiersin.org/article/10.3389/fimmu.2019.01533/full https://doaj.org/toc/1664-3224
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up_date	2024-07-03T19:15:29.079Z
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