Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?

Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and R...
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Autor*in:	Raimon Sanmartí [verfasserIn] Beatriz Frade-Sosa [verfasserIn] Rosa Morlà [verfasserIn] Raul Castellanos-Moreira [verfasserIn] Sonia Cabrera-Villalba [verfasserIn] Julio Ramirez [verfasserIn] Georgina Salvador [verfasserIn] Isabel Haro [verfasserIn] Juan D. Cañete [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	palindromic rheumatism rheumatoid arthritis ACPA pre-RA management

Übergeordnetes Werk:	In: Frontiers in Medicine - Frontiers Media S.A., 2014, 8(2021)
Übergeordnetes Werk:	volume:8 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmed.2021.657983

Katalog-ID:	DOAJ048822450

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allfields	10.3389/fmed.2021.657983 doi (DE-627)DOAJ048822450 (DE-599)DOAJ51eac56a54db44a3894a81e337c753f5 DE-627 ger DE-627 rakwb eng R5-920 Raimon Sanmartí verfasserin aut Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. palindromic rheumatism rheumatoid arthritis ACPA pre-RA management Medicine (General) Beatriz Frade-Sosa verfasserin aut Rosa Morlà verfasserin aut Raul Castellanos-Moreira verfasserin aut Sonia Cabrera-Villalba verfasserin aut Sonia Cabrera-Villalba verfasserin aut Julio Ramirez verfasserin aut Georgina Salvador verfasserin aut Isabel Haro verfasserin aut Juan D. Cañete verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.657983 kostenfrei https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
spelling	10.3389/fmed.2021.657983 doi (DE-627)DOAJ048822450 (DE-599)DOAJ51eac56a54db44a3894a81e337c753f5 DE-627 ger DE-627 rakwb eng R5-920 Raimon Sanmartí verfasserin aut Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. palindromic rheumatism rheumatoid arthritis ACPA pre-RA management Medicine (General) Beatriz Frade-Sosa verfasserin aut Rosa Morlà verfasserin aut Raul Castellanos-Moreira verfasserin aut Sonia Cabrera-Villalba verfasserin aut Sonia Cabrera-Villalba verfasserin aut Julio Ramirez verfasserin aut Georgina Salvador verfasserin aut Isabel Haro verfasserin aut Juan D. Cañete verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.657983 kostenfrei https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfields_unstemmed	10.3389/fmed.2021.657983 doi (DE-627)DOAJ048822450 (DE-599)DOAJ51eac56a54db44a3894a81e337c753f5 DE-627 ger DE-627 rakwb eng R5-920 Raimon Sanmartí verfasserin aut Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. palindromic rheumatism rheumatoid arthritis ACPA pre-RA management Medicine (General) Beatriz Frade-Sosa verfasserin aut Rosa Morlà verfasserin aut Raul Castellanos-Moreira verfasserin aut Sonia Cabrera-Villalba verfasserin aut Sonia Cabrera-Villalba verfasserin aut Julio Ramirez verfasserin aut Georgina Salvador verfasserin aut Isabel Haro verfasserin aut Juan D. Cañete verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.657983 kostenfrei https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsGer	10.3389/fmed.2021.657983 doi (DE-627)DOAJ048822450 (DE-599)DOAJ51eac56a54db44a3894a81e337c753f5 DE-627 ger DE-627 rakwb eng R5-920 Raimon Sanmartí verfasserin aut Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. palindromic rheumatism rheumatoid arthritis ACPA pre-RA management Medicine (General) Beatriz Frade-Sosa verfasserin aut Rosa Morlà verfasserin aut Raul Castellanos-Moreira verfasserin aut Sonia Cabrera-Villalba verfasserin aut Sonia Cabrera-Villalba verfasserin aut Julio Ramirez verfasserin aut Georgina Salvador verfasserin aut Isabel Haro verfasserin aut Juan D. Cañete verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.657983 kostenfrei https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsSound	10.3389/fmed.2021.657983 doi (DE-627)DOAJ048822450 (DE-599)DOAJ51eac56a54db44a3894a81e337c753f5 DE-627 ger DE-627 rakwb eng R5-920 Raimon Sanmartí verfasserin aut Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. palindromic rheumatism rheumatoid arthritis ACPA pre-RA management Medicine (General) Beatriz Frade-Sosa verfasserin aut Rosa Morlà verfasserin aut Raul Castellanos-Moreira verfasserin aut Sonia Cabrera-Villalba verfasserin aut Sonia Cabrera-Villalba verfasserin aut Julio Ramirez verfasserin aut Georgina Salvador verfasserin aut Isabel Haro verfasserin aut Juan D. Cañete verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.657983 kostenfrei https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
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author	Raimon Sanmartí
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topic_title	R5-920 Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? palindromic rheumatism rheumatoid arthritis ACPA pre-RA management
topic	misc R5-920 misc palindromic rheumatism misc rheumatoid arthritis misc ACPA misc pre-RA misc management misc Medicine (General)
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title	Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
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title_full	Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
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author_browse	Raimon Sanmartí Beatriz Frade-Sosa Rosa Morlà Raul Castellanos-Moreira Sonia Cabrera-Villalba Julio Ramirez Georgina Salvador Isabel Haro Juan D. Cañete
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title_sort	palindromic rheumatism: just a pre-rheumatoid stage or something else?
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title_auth	Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
abstract	Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.
abstractGer	Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.
abstract_unstemmed	Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.
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title_short	Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
url	https://doi.org/10.3389/fmed.2021.657983 https://doaj.org/article/51eac56a54db44a3894a81e337c753f5 https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full https://doaj.org/toc/2296-858X
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author2	Beatriz Frade-Sosa Rosa Morlà Raul Castellanos-Moreira Sonia Cabrera-Villalba Julio Ramirez Georgina Salvador Isabel Haro Juan D. Cañete
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It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. 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