Major regulatory mechanisms involved in sperm motility

The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and correcte...
Ausführliche Beschreibung

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Autor*in:	Rute Pereira [verfasserIn] Rosália Sá [verfasserIn] Alberto Barros [verfasserIn] Mário Sousa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility

Übergeordnetes Werk:	In: Asian Journal of Andrology - Wolters Kluwer Medknow Publications, 2014, 19(2017), 1, Seite 5-14
Übergeordnetes Werk:	volume:19 ; year:2017 ; number:1 ; pages:5-14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/1008-682X.167716

Katalog-ID:	DOAJ048857505

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520			\|a The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.
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spelling	10.4103/1008-682X.167716 doi (DE-627)DOAJ048857505 (DE-599)DOAJ9de45b0bc6ef47679a202ea65e4198c5 DE-627 ger DE-627 rakwb eng RC870-923 Rute Pereira verfasserin aut Major regulatory mechanisms involved in sperm motility 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies. antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility Diseases of the genitourinary system. Urology Rosália Sá verfasserin aut Alberto Barros verfasserin aut Mário Sousa verfasserin aut In Asian Journal of Andrology Wolters Kluwer Medknow Publications, 2014 19(2017), 1, Seite 5-14 (DE-627)352261013 (DE-600)2085228-9 17457262 nnns volume:19 year:2017 number:1 pages:5-14 https://doi.org/10.4103/1008-682X.167716 kostenfrei https://doaj.org/article/9de45b0bc6ef47679a202ea65e4198c5 kostenfrei http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=5;epage=14;aulast=Pereira kostenfrei https://doaj.org/toc/1008-682X Journal toc kostenfrei https://doaj.org/toc/1745-7262 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2017 1 5-14
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allfieldsGer	10.4103/1008-682X.167716 doi (DE-627)DOAJ048857505 (DE-599)DOAJ9de45b0bc6ef47679a202ea65e4198c5 DE-627 ger DE-627 rakwb eng RC870-923 Rute Pereira verfasserin aut Major regulatory mechanisms involved in sperm motility 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies. antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility Diseases of the genitourinary system. Urology Rosália Sá verfasserin aut Alberto Barros verfasserin aut Mário Sousa verfasserin aut In Asian Journal of Andrology Wolters Kluwer Medknow Publications, 2014 19(2017), 1, Seite 5-14 (DE-627)352261013 (DE-600)2085228-9 17457262 nnns volume:19 year:2017 number:1 pages:5-14 https://doi.org/10.4103/1008-682X.167716 kostenfrei https://doaj.org/article/9de45b0bc6ef47679a202ea65e4198c5 kostenfrei http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=5;epage=14;aulast=Pereira kostenfrei https://doaj.org/toc/1008-682X Journal toc kostenfrei https://doaj.org/toc/1745-7262 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2017 1 5-14
allfieldsSound	10.4103/1008-682X.167716 doi (DE-627)DOAJ048857505 (DE-599)DOAJ9de45b0bc6ef47679a202ea65e4198c5 DE-627 ger DE-627 rakwb eng RC870-923 Rute Pereira verfasserin aut Major regulatory mechanisms involved in sperm motility 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies. antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility Diseases of the genitourinary system. Urology Rosália Sá verfasserin aut Alberto Barros verfasserin aut Mário Sousa verfasserin aut In Asian Journal of Andrology Wolters Kluwer Medknow Publications, 2014 19(2017), 1, Seite 5-14 (DE-627)352261013 (DE-600)2085228-9 17457262 nnns volume:19 year:2017 number:1 pages:5-14 https://doi.org/10.4103/1008-682X.167716 kostenfrei https://doaj.org/article/9de45b0bc6ef47679a202ea65e4198c5 kostenfrei http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=5;epage=14;aulast=Pereira kostenfrei https://doaj.org/toc/1008-682X Journal toc kostenfrei https://doaj.org/toc/1745-7262 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2017 1 5-14
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topic_facet	antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility Diseases of the genitourinary system. Urology
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callnumber-first	R - Medicine
author	Rute Pereira
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topic_title	RC870-923 Major regulatory mechanisms involved in sperm motility antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility
topic	misc RC870-923 misc antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc antioxidants; calcium; membrane channels; protein kinases; sperm genetic abnormalities; sperm motility misc Diseases of the genitourinary system. Urology
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title	Major regulatory mechanisms involved in sperm motility
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title_sort	major regulatory mechanisms involved in sperm motility
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title_auth	Major regulatory mechanisms involved in sperm motility
abstract	The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.
abstractGer	The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.
abstract_unstemmed	The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.
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title_short	Major regulatory mechanisms involved in sperm motility
url	https://doi.org/10.4103/1008-682X.167716 https://doaj.org/article/9de45b0bc6ef47679a202ea65e4198c5 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=5;epage=14;aulast=Pereira https://doaj.org/toc/1008-682X https://doaj.org/toc/1745-7262
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Major regulatory mechanisms involved in sperm motility

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