Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Qiu H [verfasserIn] Cheng C [verfasserIn] Wang Y [verfasserIn] Kang M [verfasserIn] Tang W [verfasserIn] Chen S [verfasserIn] Gu H [verfasserIn] Liu C [verfasserIn] Chen Y [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis

Übergeordnetes Werk:	In: OncoTargets and Therapy - Dove Medical Press, 2009, (2016), Seite 6641-6650
Übergeordnetes Werk:	year:2016 ; pages:6641-6650

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ049016377

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allfields	(DE-627)DOAJ049016377 (DE-599)DOAJ0f1f59b6d3f0474796d1a05f91554658 DE-627 ger DE-627 rakwb eng RC254-282 Qiu H verfasserin aut Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cheng C verfasserin aut Wang Y verfasserin aut Kang M verfasserin aut Tang W verfasserin aut Chen S verfasserin aut Gu H verfasserin aut Liu C verfasserin aut Chen Y verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Seite 6641-6650 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 pages:6641-6650 https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 kostenfrei https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 6641-6650
spelling	(DE-627)DOAJ049016377 (DE-599)DOAJ0f1f59b6d3f0474796d1a05f91554658 DE-627 ger DE-627 rakwb eng RC254-282 Qiu H verfasserin aut Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cheng C verfasserin aut Wang Y verfasserin aut Kang M verfasserin aut Tang W verfasserin aut Chen S verfasserin aut Gu H verfasserin aut Liu C verfasserin aut Chen Y verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Seite 6641-6650 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 pages:6641-6650 https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 kostenfrei https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 6641-6650
allfields_unstemmed	(DE-627)DOAJ049016377 (DE-599)DOAJ0f1f59b6d3f0474796d1a05f91554658 DE-627 ger DE-627 rakwb eng RC254-282 Qiu H verfasserin aut Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cheng C verfasserin aut Wang Y verfasserin aut Kang M verfasserin aut Tang W verfasserin aut Chen S verfasserin aut Gu H verfasserin aut Liu C verfasserin aut Chen Y verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Seite 6641-6650 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 pages:6641-6650 https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 kostenfrei https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 6641-6650
allfieldsGer	(DE-627)DOAJ049016377 (DE-599)DOAJ0f1f59b6d3f0474796d1a05f91554658 DE-627 ger DE-627 rakwb eng RC254-282 Qiu H verfasserin aut Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cheng C verfasserin aut Wang Y verfasserin aut Kang M verfasserin aut Tang W verfasserin aut Chen S verfasserin aut Gu H verfasserin aut Liu C verfasserin aut Chen Y verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Seite 6641-6650 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 pages:6641-6650 https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 kostenfrei https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 6641-6650
allfieldsSound	(DE-627)DOAJ049016377 (DE-599)DOAJ0f1f59b6d3f0474796d1a05f91554658 DE-627 ger DE-627 rakwb eng RC254-282 Qiu H verfasserin aut Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cheng C verfasserin aut Wang Y verfasserin aut Kang M verfasserin aut Tang W verfasserin aut Chen S verfasserin aut Gu H verfasserin aut Liu C verfasserin aut Chen Y verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2016), Seite 6641-6650 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2016 pages:6641-6650 https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 kostenfrei https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2016 6641-6650
language	English
source	In OncoTargets and Therapy (2016), Seite 6641-6650 year:2016 pages:6641-6650
sourceStr	In OncoTargets and Therapy (2016), Seite 6641-6650 year:2016 pages:6641-6650
format_phy_str_mv	Article
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topic_facet	Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	OncoTargets and Therapy
authorswithroles_txt_mv	Qiu H @@aut@@ Cheng C @@aut@@ Wang Y @@aut@@ Kang M @@aut@@ Tang W @@aut@@ Chen S @@aut@@ Gu H @@aut@@ Liu C @@aut@@ Chen Y @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Qiu H
spellingShingle	Qiu H misc RC254-282 misc Polymorphism misc CCND1 misc Colorectal cancer misc Susceptibility misc Meta-analysis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
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topic_title	RC254-282 Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects Polymorphism CCND1 Colorectal cancer Susceptibility Meta-analysis
topic	misc RC254-282 misc Polymorphism misc CCND1 misc Colorectal cancer misc Susceptibility misc Meta-analysis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Polymorphism misc CCND1 misc Colorectal cancer misc Susceptibility misc Meta-analysis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
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title_full	Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
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title_sort	investigation of cyclin d1 rs9344 g>a polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
callnumber	RC254-282
title_auth	Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
abstract	Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis
abstractGer	Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis
abstract_unstemmed	Hao Qiu,1,* Chengguo Cheng,2,* Yafeng Wang,3 Mingqiang Kang,4 Weifeng Tang,4,5 Shuchen Chen,4 Haiyong Gu,6 Chao Liu,5 Yu Chen7,8 1Department of Immunology, School of Medicine, Jiangsu University, 2Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, 3Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, 4Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 5Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, 8Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The relationship between cyclin D1 (CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between CCND1 rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between CCND1 rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that CCND1 rs9344 G>A polymorphism may be a risk factor for CRC. Keywords: polymorphism, CCND1, colorectal cancer, susceptibility, meta-analysis
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title_short	Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects
url	https://doaj.org/article/0f1f59b6d3f0474796d1a05f91554658 https://www.dovepress.com/investigation-of-cyclin-d1-rs9344-ggta-polymorphism-in-colorectal-canc-peer-reviewed-article-OTT https://doaj.org/toc/1178-6930
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Investigation of cyclin D1 rs9344 G&gt;A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

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Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects