Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer

Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-fre...
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Autor*in:	Rosa M. Jimenez-Rodriguez [verfasserIn] Sujata Patil [verfasserIn] Ajaratu Keshinro [verfasserIn] Jinru Shia [verfasserIn] Efsevia Vakiani [verfasserIn] Zsofia Stadler [verfasserIn] Neil H. Segal [verfasserIn] Rona Yaeger [verfasserIn] Tsuyoshi Konishi [verfasserIn] Yoshifumi Shimada [verfasserIn] Maria Widmar [verfasserIn] Iris Wei [verfasserIn] Emmanouil Pappou [verfasserIn] J. Joshua Smith [verfasserIn] Garrett Nash [verfasserIn] Philip Paty [verfasserIn] Julio Garcia-Aguilar [verfasserIn] Martin R. Weiser [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	colon cancer tumor-infiltrating lymphocytes mismatch repair survival

Übergeordnetes Werk:	In: OncoImmunology - Taylor & Francis Group, 2020, 9(2020), 1
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/2162402X.2020.1841948

Katalog-ID:	DOAJ049055801

Internformat


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520			\|a Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage.
650		4	\|a colon cancer
650		4	\|a tumor-infiltrating lymphocytes
650		4	\|a mismatch repair
650		4	\|a survival
653		0	\|a Immunologic diseases. Allergy
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.1080/2162402X.2020.1841948 doi (DE-627)DOAJ049055801 (DE-599)DOAJe3b7505e7cd74e1fa57c3200bbd9c45f DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Rosa M. Jimenez-Rodriguez verfasserin aut Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage. colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sujata Patil verfasserin aut Ajaratu Keshinro verfasserin aut Jinru Shia verfasserin aut Efsevia Vakiani verfasserin aut Zsofia Stadler verfasserin aut Neil H. Segal verfasserin aut Rona Yaeger verfasserin aut Tsuyoshi Konishi verfasserin aut Yoshifumi Shimada verfasserin aut Maria Widmar verfasserin aut Iris Wei verfasserin aut Emmanouil Pappou verfasserin aut J. Joshua Smith verfasserin aut Garrett Nash verfasserin aut Philip Paty verfasserin aut Julio Garcia-Aguilar verfasserin aut Martin R. Weiser verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
spelling	10.1080/2162402X.2020.1841948 doi (DE-627)DOAJ049055801 (DE-599)DOAJe3b7505e7cd74e1fa57c3200bbd9c45f DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Rosa M. Jimenez-Rodriguez verfasserin aut Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage. colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sujata Patil verfasserin aut Ajaratu Keshinro verfasserin aut Jinru Shia verfasserin aut Efsevia Vakiani verfasserin aut Zsofia Stadler verfasserin aut Neil H. Segal verfasserin aut Rona Yaeger verfasserin aut Tsuyoshi Konishi verfasserin aut Yoshifumi Shimada verfasserin aut Maria Widmar verfasserin aut Iris Wei verfasserin aut Emmanouil Pappou verfasserin aut J. Joshua Smith verfasserin aut Garrett Nash verfasserin aut Philip Paty verfasserin aut Julio Garcia-Aguilar verfasserin aut Martin R. Weiser verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
allfields_unstemmed	10.1080/2162402X.2020.1841948 doi (DE-627)DOAJ049055801 (DE-599)DOAJe3b7505e7cd74e1fa57c3200bbd9c45f DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Rosa M. Jimenez-Rodriguez verfasserin aut Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage. colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sujata Patil verfasserin aut Ajaratu Keshinro verfasserin aut Jinru Shia verfasserin aut Efsevia Vakiani verfasserin aut Zsofia Stadler verfasserin aut Neil H. Segal verfasserin aut Rona Yaeger verfasserin aut Tsuyoshi Konishi verfasserin aut Yoshifumi Shimada verfasserin aut Maria Widmar verfasserin aut Iris Wei verfasserin aut Emmanouil Pappou verfasserin aut J. Joshua Smith verfasserin aut Garrett Nash verfasserin aut Philip Paty verfasserin aut Julio Garcia-Aguilar verfasserin aut Martin R. Weiser verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
allfieldsGer	10.1080/2162402X.2020.1841948 doi (DE-627)DOAJ049055801 (DE-599)DOAJe3b7505e7cd74e1fa57c3200bbd9c45f DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Rosa M. Jimenez-Rodriguez verfasserin aut Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage. colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sujata Patil verfasserin aut Ajaratu Keshinro verfasserin aut Jinru Shia verfasserin aut Efsevia Vakiani verfasserin aut Zsofia Stadler verfasserin aut Neil H. Segal verfasserin aut Rona Yaeger verfasserin aut Tsuyoshi Konishi verfasserin aut Yoshifumi Shimada verfasserin aut Maria Widmar verfasserin aut Iris Wei verfasserin aut Emmanouil Pappou verfasserin aut J. Joshua Smith verfasserin aut Garrett Nash verfasserin aut Philip Paty verfasserin aut Julio Garcia-Aguilar verfasserin aut Martin R. Weiser verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
allfieldsSound	10.1080/2162402X.2020.1841948 doi (DE-627)DOAJ049055801 (DE-599)DOAJe3b7505e7cd74e1fa57c3200bbd9c45f DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Rosa M. Jimenez-Rodriguez verfasserin aut Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage. colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sujata Patil verfasserin aut Ajaratu Keshinro verfasserin aut Jinru Shia verfasserin aut Efsevia Vakiani verfasserin aut Zsofia Stadler verfasserin aut Neil H. Segal verfasserin aut Rona Yaeger verfasserin aut Tsuyoshi Konishi verfasserin aut Yoshifumi Shimada verfasserin aut Maria Widmar verfasserin aut Iris Wei verfasserin aut Emmanouil Pappou verfasserin aut J. Joshua Smith verfasserin aut Garrett Nash verfasserin aut Philip Paty verfasserin aut Julio Garcia-Aguilar verfasserin aut Martin R. Weiser verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1841948 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
language	English
source	In OncoImmunology 9(2020), 1 volume:9 year:2020 number:1
sourceStr	In OncoImmunology 9(2020), 1 volume:9 year:2020 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	colon cancer tumor-infiltrating lymphocytes mismatch repair survival Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	OncoImmunology
authorswithroles_txt_mv	Rosa M. Jimenez-Rodriguez @@aut@@ Sujata Patil @@aut@@ Ajaratu Keshinro @@aut@@ Jinru Shia @@aut@@ Efsevia Vakiani @@aut@@ Zsofia Stadler @@aut@@ Neil H. Segal @@aut@@ Rona Yaeger @@aut@@ Tsuyoshi Konishi @@aut@@ Yoshifumi Shimada @@aut@@ Maria Widmar @@aut@@ Iris Wei @@aut@@ Emmanouil Pappou @@aut@@ J. Joshua Smith @@aut@@ Garrett Nash @@aut@@ Philip Paty @@aut@@ Julio Garcia-Aguilar @@aut@@ Martin R. Weiser @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	683365428
id	DOAJ049055801
language_de	englisch
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callnumber-first	R - Medicine
author	Rosa M. Jimenez-Rodriguez
spellingShingle	Rosa M. Jimenez-Rodriguez misc RC581-607 misc RC254-282 misc colon cancer misc tumor-infiltrating lymphocytes misc mismatch repair misc survival misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
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topic_title	RC581-607 RC254-282 Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer colon cancer tumor-infiltrating lymphocytes mismatch repair survival
topic	misc RC581-607 misc RC254-282 misc colon cancer misc tumor-infiltrating lymphocytes misc mismatch repair misc survival misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC581-607 misc RC254-282 misc colon cancer misc tumor-infiltrating lymphocytes misc mismatch repair misc survival misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC581-607 misc RC254-282 misc colon cancer misc tumor-infiltrating lymphocytes misc mismatch repair misc survival misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
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title_full	Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
author_sort	Rosa M. Jimenez-Rodriguez
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author_browse	Rosa M. Jimenez-Rodriguez Sujata Patil Ajaratu Keshinro Jinru Shia Efsevia Vakiani Zsofia Stadler Neil H. Segal Rona Yaeger Tsuyoshi Konishi Yoshifumi Shimada Maria Widmar Iris Wei Emmanouil Pappou J. Joshua Smith Garrett Nash Philip Paty Julio Garcia-Aguilar Martin R. Weiser
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author-letter	Rosa M. Jimenez-Rodriguez
doi_str_mv	10.1080/2162402X.2020.1841948
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title_sort	quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
callnumber	RC581-607
title_auth	Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
abstract	Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage.
abstractGer	Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage.
abstract_unstemmed	Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF), and analyzed for association with recurrence-free survival (RFS) in 848 patients. Highest TIL in a single HPF was analyzed as a continuous and categorical variable, and optimal cutoff analysis was performed to predict RFS. Highest TIL count in a single HPF ranged from 0 to 45, and the optimal cutoff for TIL high vs TIL low was determined to be ≥ 3 vs < 3 with a concordance probability estimate of 0.74. In the entire cohort, 5-year RFS was 90.2% (95% CI = 83.7–94.2) in TIL high compared to 78.9% (95% CI = 74.1–82.9) in TIL low (log rank P < .0001). TIL remained significant in the mismatch repair-proficient (pMMR) cohort where 5-year RFS was 94.6% (95% CI = 88.3–97.5) in TIL high compared to 77.9% (95% CI = 69.2–84.4) in TIL low (P = .008). On multivariable analysis, TIL and AJCC Stage were independently associated with RFS in the pMMR cohort. Qualitatively in the pMMR cohort, RFS in Stage II TIL high patients was similar to that in Stage I patients and RFS in Stage III TIL high was similar to that in Stage II TIL low patients. Assessment of TIL in a single HPF using standard H&E slides provides important prognostic information independent of MMR status and AJCC stage.
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title_short	Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
url	https://doi.org/10.1080/2162402X.2020.1841948 https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f http://dx.doi.org/10.1080/2162402X.2020.1841948 https://doaj.org/toc/2162-402X
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author2Str	Sujata Patil Ajaratu Keshinro Jinru Shia Efsevia Vakiani Zsofia Stadler Neil H. Segal Rona Yaeger Tsuyoshi Konishi Yoshifumi Shimada Maria Widmar Iris Wei Emmanouil Pappou J. Joshua Smith Garrett Nash Philip Paty Julio Garcia-Aguilar Martin R. Weiser
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Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer

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