The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence in...
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Autor*in:	Yuyi Han [verfasserIn] Jianxin Yang [verfasserIn] Jiankai Fang [verfasserIn] Yipeng Zhou [verfasserIn] Eleonora Candi [verfasserIn] Jihong Wang [verfasserIn] Dong Hua [verfasserIn] Changshun Shao [verfasserIn] Yufang Shi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Signal Transduction and Targeted Therapy - Nature Publishing Group, 2016, 7(2022), 1, Seite 19
Übergeordnetes Werk:	volume:7 ; year:2022 ; number:1 ; pages:19

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41392-022-00932-0

Katalog-ID:	DOAJ049074008

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spelling	10.1038/s41392-022-00932-0 doi (DE-627)DOAJ049074008 (DE-599)DOAJ55a254d6397d4ce7a0fde36cb8e76cb0 DE-627 ger DE-627 rakwb eng QH301-705.5 Yuyi Han verfasserin aut The secretion profile of mesenchymal stem cells and potential applications in treating human diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. Medicine R Biology (General) Jianxin Yang verfasserin aut Jiankai Fang verfasserin aut Yipeng Zhou verfasserin aut Eleonora Candi verfasserin aut Jihong Wang verfasserin aut Dong Hua verfasserin aut Changshun Shao verfasserin aut Yufang Shi verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 7(2022), 1, Seite 19 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:7 year:2022 number:1 pages:19 https://doi.org/10.1038/s41392-022-00932-0 kostenfrei https://doaj.org/article/55a254d6397d4ce7a0fde36cb8e76cb0 kostenfrei https://doi.org/10.1038/s41392-022-00932-0 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2022 1 19
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allfieldsSound	10.1038/s41392-022-00932-0 doi (DE-627)DOAJ049074008 (DE-599)DOAJ55a254d6397d4ce7a0fde36cb8e76cb0 DE-627 ger DE-627 rakwb eng QH301-705.5 Yuyi Han verfasserin aut The secretion profile of mesenchymal stem cells and potential applications in treating human diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. Medicine R Biology (General) Jianxin Yang verfasserin aut Jiankai Fang verfasserin aut Yipeng Zhou verfasserin aut Eleonora Candi verfasserin aut Jihong Wang verfasserin aut Dong Hua verfasserin aut Changshun Shao verfasserin aut Yufang Shi verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 7(2022), 1, Seite 19 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:7 year:2022 number:1 pages:19 https://doi.org/10.1038/s41392-022-00932-0 kostenfrei https://doaj.org/article/55a254d6397d4ce7a0fde36cb8e76cb0 kostenfrei https://doi.org/10.1038/s41392-022-00932-0 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2022 1 19
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title_auth	The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
abstract	Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.
abstractGer	Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.
abstract_unstemmed	Abstract Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.
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title_short	The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
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The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

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