Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis

<p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and i...
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Autor*in:	Moradi Shahram [verfasserIn] Jaffary Fariba [verfasserIn] Nilforoushzadeh Mohammad [verfasserIn] Derakhshan Roya [verfasserIn] Haftbaradaran Elaheh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Übergeordnetes Werk:	In: BMC Complementary and Alternative Medicine - BMC, 2003, 7(2007), 1, p 13
Übergeordnetes Werk:	volume:7 ; year:2007 ; number:1, p 13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1472-6882-7-13

Katalog-ID:	DOAJ049091484

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allfields	10.1186/1472-6882-7-13 doi (DE-627)DOAJ049091484 (DE-599)DOAJbf02d81e8ed04c75b19eb90baccfdeef DE-627 ger DE-627 rakwb eng RZ201-999 Moradi Shahram verfasserin aut Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p< Other systems of medicine Jaffary Fariba verfasserin aut Nilforoushzadeh Mohammad verfasserin aut Derakhshan Roya verfasserin aut Haftbaradaran Elaheh verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 7(2007), 1, p 13 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:7 year:2007 number:1, p 13 https://doi.org/10.1186/1472-6882-7-13 kostenfrei https://doaj.org/article/bf02d81e8ed04c75b19eb90baccfdeef kostenfrei http://www.biomedcentral.com/1472-6882/7/13 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 13
spelling	10.1186/1472-6882-7-13 doi (DE-627)DOAJ049091484 (DE-599)DOAJbf02d81e8ed04c75b19eb90baccfdeef DE-627 ger DE-627 rakwb eng RZ201-999 Moradi Shahram verfasserin aut Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p< Other systems of medicine Jaffary Fariba verfasserin aut Nilforoushzadeh Mohammad verfasserin aut Derakhshan Roya verfasserin aut Haftbaradaran Elaheh verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 7(2007), 1, p 13 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:7 year:2007 number:1, p 13 https://doi.org/10.1186/1472-6882-7-13 kostenfrei https://doaj.org/article/bf02d81e8ed04c75b19eb90baccfdeef kostenfrei http://www.biomedcentral.com/1472-6882/7/13 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 13
allfields_unstemmed	10.1186/1472-6882-7-13 doi (DE-627)DOAJ049091484 (DE-599)DOAJbf02d81e8ed04c75b19eb90baccfdeef DE-627 ger DE-627 rakwb eng RZ201-999 Moradi Shahram verfasserin aut Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p< Other systems of medicine Jaffary Fariba verfasserin aut Nilforoushzadeh Mohammad verfasserin aut Derakhshan Roya verfasserin aut Haftbaradaran Elaheh verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 7(2007), 1, p 13 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:7 year:2007 number:1, p 13 https://doi.org/10.1186/1472-6882-7-13 kostenfrei https://doaj.org/article/bf02d81e8ed04c75b19eb90baccfdeef kostenfrei http://www.biomedcentral.com/1472-6882/7/13 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 13
allfieldsGer	10.1186/1472-6882-7-13 doi (DE-627)DOAJ049091484 (DE-599)DOAJbf02d81e8ed04c75b19eb90baccfdeef DE-627 ger DE-627 rakwb eng RZ201-999 Moradi Shahram verfasserin aut Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p< Other systems of medicine Jaffary Fariba verfasserin aut Nilforoushzadeh Mohammad verfasserin aut Derakhshan Roya verfasserin aut Haftbaradaran Elaheh verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 7(2007), 1, p 13 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:7 year:2007 number:1, p 13 https://doi.org/10.1186/1472-6882-7-13 kostenfrei https://doaj.org/article/bf02d81e8ed04c75b19eb90baccfdeef kostenfrei http://www.biomedcentral.com/1472-6882/7/13 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 13
allfieldsSound	10.1186/1472-6882-7-13 doi (DE-627)DOAJ049091484 (DE-599)DOAJbf02d81e8ed04c75b19eb90baccfdeef DE-627 ger DE-627 rakwb eng RZ201-999 Moradi Shahram verfasserin aut Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p< Other systems of medicine Jaffary Fariba verfasserin aut Nilforoushzadeh Mohammad verfasserin aut Derakhshan Roya verfasserin aut Haftbaradaran Elaheh verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 7(2007), 1, p 13 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:7 year:2007 number:1, p 13 https://doi.org/10.1186/1472-6882-7-13 kostenfrei https://doaj.org/article/bf02d81e8ed04c75b19eb90baccfdeef kostenfrei http://www.biomedcentral.com/1472-6882/7/13 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 13
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author	Moradi Shahram
spellingShingle	Moradi Shahram misc RZ201-999 misc Other systems of medicine Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
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topic_title	RZ201-999 Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
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title	Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
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title_full	Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
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author_browse	Moradi Shahram Jaffary Fariba Nilforoushzadeh Mohammad Derakhshan Roya Haftbaradaran Elaheh
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author-letter	Moradi Shahram
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title_sort	effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
callnumber	RZ201-999
title_auth	Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
abstract	<p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.</p< <p<Methods</p< <p<In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.</p< <p<Results</p< <p<In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).</p< <p<Conclusion</p< <p<Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.</p<
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title_short	Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
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Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis

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