Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants we...
Ausführliche Beschreibung
Autor*in: |
Mary Isabel O'Dea [verfasserIn] Lynne A. Kelly [verfasserIn] Ellen McKenna [verfasserIn] Tammy Strickland [verfasserIn] Tim P. Hurley [verfasserIn] John Butler [verfasserIn] Claudine Vavasseur [verfasserIn] Afif F. EL-Khuffash [verfasserIn] Jan Miletin [verfasserIn] Lida Fallah [verfasserIn] Arthur White [verfasserIn] Jason Wyse [verfasserIn] Eleanor J. Molloy [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 9(2021) |
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Übergeordnetes Werk: |
volume:9 ; year:2021 |
Links: |
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DOI / URN: |
10.3389/fped.2021.734540 |
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Katalog-ID: |
DOAJ049123491 |
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520 | |a Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. | ||
650 | 4 | |a neonatal encephalopathy | |
650 | 4 | |a hypoxic-ischaemic encephalopathy | |
650 | 4 | |a cytokines | |
650 | 4 | |a lipopolysaccharide | |
650 | 4 | |a MRI | |
650 | 4 | |a neurodevelopment | |
653 | 0 | |a Pediatrics | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Mary Isabel O'Dea |e verfasserin |4 aut | |
700 | 0 | |a Lynne A. Kelly |e verfasserin |4 aut | |
700 | 0 | |a Lynne A. Kelly |e verfasserin |4 aut | |
700 | 0 | |a Lynne A. Kelly |e verfasserin |4 aut | |
700 | 0 | |a Ellen McKenna |e verfasserin |4 aut | |
700 | 0 | |a Ellen McKenna |e verfasserin |4 aut | |
700 | 0 | |a Tammy Strickland |e verfasserin |4 aut | |
700 | 0 | |a Tammy Strickland |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a Tim P. Hurley |e verfasserin |4 aut | |
700 | 0 | |a John Butler |e verfasserin |4 aut | |
700 | 0 | |a Claudine Vavasseur |e verfasserin |4 aut | |
700 | 0 | |a Afif F. EL-Khuffash |e verfasserin |4 aut | |
700 | 0 | |a Afif F. EL-Khuffash |e verfasserin |4 aut | |
700 | 0 | |a Jan Miletin |e verfasserin |4 aut | |
700 | 0 | |a Jan Miletin |e verfasserin |4 aut | |
700 | 0 | |a Lida Fallah |e verfasserin |4 aut | |
700 | 0 | |a Arthur White |e verfasserin |4 aut | |
700 | 0 | |a Jason Wyse |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
700 | 0 | |a Eleanor J. Molloy |e verfasserin |4 aut | |
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10.3389/fped.2021.734540 doi (DE-627)DOAJ049123491 (DE-599)DOAJb4022f163d7f4286a8112c6a78afc9d3 DE-627 ger DE-627 rakwb eng RJ1-570 Mary Isabel O'Dea verfasserin aut Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment Pediatrics Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Ellen McKenna verfasserin aut Ellen McKenna verfasserin aut Tammy Strickland verfasserin aut Tammy Strickland verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut John Butler verfasserin aut Claudine Vavasseur verfasserin aut Afif F. EL-Khuffash verfasserin aut Afif F. EL-Khuffash verfasserin aut Jan Miletin verfasserin aut Jan Miletin verfasserin aut Lida Fallah verfasserin aut Arthur White verfasserin aut Jason Wyse verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.734540 kostenfrei https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 |
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10.3389/fped.2021.734540 doi (DE-627)DOAJ049123491 (DE-599)DOAJb4022f163d7f4286a8112c6a78afc9d3 DE-627 ger DE-627 rakwb eng RJ1-570 Mary Isabel O'Dea verfasserin aut Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment Pediatrics Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Ellen McKenna verfasserin aut Ellen McKenna verfasserin aut Tammy Strickland verfasserin aut Tammy Strickland verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut John Butler verfasserin aut Claudine Vavasseur verfasserin aut Afif F. EL-Khuffash verfasserin aut Afif F. EL-Khuffash verfasserin aut Jan Miletin verfasserin aut Jan Miletin verfasserin aut Lida Fallah verfasserin aut Arthur White verfasserin aut Jason Wyse verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.734540 kostenfrei https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 |
allfields_unstemmed |
10.3389/fped.2021.734540 doi (DE-627)DOAJ049123491 (DE-599)DOAJb4022f163d7f4286a8112c6a78afc9d3 DE-627 ger DE-627 rakwb eng RJ1-570 Mary Isabel O'Dea verfasserin aut Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment Pediatrics Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Ellen McKenna verfasserin aut Ellen McKenna verfasserin aut Tammy Strickland verfasserin aut Tammy Strickland verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut John Butler verfasserin aut Claudine Vavasseur verfasserin aut Afif F. EL-Khuffash verfasserin aut Afif F. EL-Khuffash verfasserin aut Jan Miletin verfasserin aut Jan Miletin verfasserin aut Lida Fallah verfasserin aut Arthur White verfasserin aut Jason Wyse verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.734540 kostenfrei https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 |
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10.3389/fped.2021.734540 doi (DE-627)DOAJ049123491 (DE-599)DOAJb4022f163d7f4286a8112c6a78afc9d3 DE-627 ger DE-627 rakwb eng RJ1-570 Mary Isabel O'Dea verfasserin aut Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment Pediatrics Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Ellen McKenna verfasserin aut Ellen McKenna verfasserin aut Tammy Strickland verfasserin aut Tammy Strickland verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut John Butler verfasserin aut Claudine Vavasseur verfasserin aut Afif F. EL-Khuffash verfasserin aut Afif F. EL-Khuffash verfasserin aut Jan Miletin verfasserin aut Jan Miletin verfasserin aut Lida Fallah verfasserin aut Arthur White verfasserin aut Jason Wyse verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.734540 kostenfrei https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 |
allfieldsSound |
10.3389/fped.2021.734540 doi (DE-627)DOAJ049123491 (DE-599)DOAJb4022f163d7f4286a8112c6a78afc9d3 DE-627 ger DE-627 rakwb eng RJ1-570 Mary Isabel O'Dea verfasserin aut Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment Pediatrics Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Mary Isabel O'Dea verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Lynne A. Kelly verfasserin aut Ellen McKenna verfasserin aut Ellen McKenna verfasserin aut Tammy Strickland verfasserin aut Tammy Strickland verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut Tim P. Hurley verfasserin aut John Butler verfasserin aut Claudine Vavasseur verfasserin aut Afif F. EL-Khuffash verfasserin aut Afif F. EL-Khuffash verfasserin aut Jan Miletin verfasserin aut Jan Miletin verfasserin aut Lida Fallah verfasserin aut Arthur White verfasserin aut Jason Wyse verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut Eleanor J. Molloy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.734540 kostenfrei https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 |
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Mary Isabel O'Dea @@aut@@ Lynne A. Kelly @@aut@@ Ellen McKenna @@aut@@ Tammy Strickland @@aut@@ Tim P. Hurley @@aut@@ John Butler @@aut@@ Claudine Vavasseur @@aut@@ Afif F. EL-Khuffash @@aut@@ Jan Miletin @@aut@@ Lida Fallah @@aut@@ Arthur White @@aut@@ Jason Wyse @@aut@@ Eleanor J. Molloy @@aut@@ |
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Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. 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RJ1-570 Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes neonatal encephalopathy hypoxic-ischaemic encephalopathy cytokines lipopolysaccharide MRI neurodevelopment |
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altered cytokine endotoxin responses in neonatal encephalopathy predict mri outcomes |
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Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes |
abstract |
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. |
abstractGer |
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. |
abstract_unstemmed |
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells.Methods: Eighty-seven infants were enrolled including 53 infants with NE of whom 52 received therapeutic hypothermia (TH) and 34 term infant healthy controls (TC). Whole blood sampling was performed in the first 4 days of life, and a 14-spot ELISA Multiplex Cytokine Array was carried out on baseline samples or after stimulation with lipopolysaccharide (LPS) as an additional inflammatory stimulus. The cytokine medians were examined for differences between infants with NE and healthy TC; and then short-term outcomes of Sarnat stage, seizures, and MRI brain were examined within the NE group. The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments. |
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Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes |
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https://doi.org/10.3389/fped.2021.734540 https://doaj.org/article/b4022f163d7f4286a8112c6a78afc9d3 https://www.frontiersin.org/articles/10.3389/fped.2021.734540/full https://doaj.org/toc/2296-2360 |
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Mary Isabel O'Dea Lynne A. Kelly Ellen McKenna Tammy Strickland Tim P. Hurley John Butler Claudine Vavasseur Afif F. EL-Khuffash Jan Miletin Lida Fallah Arthur White Jason Wyse Eleanor J. Molloy |
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Mary Isabel O'Dea Lynne A. Kelly Ellen McKenna Tammy Strickland Tim P. Hurley John Butler Claudine Vavasseur Afif F. EL-Khuffash Jan Miletin Lida Fallah Arthur White Jason Wyse Eleanor J. Molloy |
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The potential of LPS stimulation to predict abnormal MRI was explored using receiver operating characteristic (ROC) curves.Results: At baseline, infants with NE had significantly higher levels of erythropoietin (Epo), interleukin (IL)-6, and IL-1ra and significantly lower vascular endothelial growth factor (VEGF) than had controls. All cytokines were increased after LPS stimulation in infants with NE with an excessive Epo and IL-1ra response than in controls. Infants with NE had lower IL-8, IL-2, IL-6, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), VEGF, and interferon (IFN)-γ than controls had following LPS. GM-CSF and IFN-γ, IL-1β, IL-1ra, and VEGF were higher on days 1–2 in NE infants with abnormal neuroimaging. GM-CSF, IFN-γ, and TNF-α levels with LPS stimulation were different upon stimulation between normal and abnormal neuroimaging. TNF-α is the only strong cytokine predictor both pre- and post-LPS stimulation of abnormal brain imaging.Conclusions: Altered cytokine responses are found in infants with NE vs. controls, and more significant differences are unmasked by the additional stimulus of LPS, which potentially improves the predictive power of these cytokines for the detection of abnormal MRIs. Infants with NE undergoing TH demonstrate both trained immunity and tolerance, and understanding these responses will facilitate adjunctive immunomodulatory treatments.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">neonatal encephalopathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hypoxic-ischaemic encephalopathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cytokines</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lipopolysaccharide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MRI</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">neurodevelopment</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pediatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary Isabel O'Dea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lynne A. 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