Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

<p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress...
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Autor*in:	Bøhn Siv K [verfasserIn] Russnes Kjell M [verfasserIn] Sakhi Amrit K [verfasserIn] Thoresen Magne [verfasserIn] Holden Marit [verfasserIn] Moskaug JanØ [verfasserIn] Myhrstad Mari C [verfasserIn] Olstad Ole K [verfasserIn] Smeland Sigbjørn [verfasserIn] Blomhoff Rune [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 12(2012), 1, p 426
Übergeordnetes Werk:	volume:12 ; year:2012 ; number:1, p 426

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2407-12-426

Katalog-ID:	DOAJ049129872

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p<
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allfields	10.1186/1471-2407-12-426 doi (DE-627)DOAJ049129872 (DE-599)DOAJ1762e31f2c9342efbe14b212152ef962 DE-627 ger DE-627 rakwb eng RC254-282 Bøhn Siv K verfasserin aut Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p< Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Russnes Kjell M verfasserin aut Sakhi Amrit K verfasserin aut Thoresen Magne verfasserin aut Holden Marit verfasserin aut Moskaug JanØ verfasserin aut Myhrstad Mari C verfasserin aut Olstad Ole K verfasserin aut Smeland Sigbjørn verfasserin aut Blomhoff Rune verfasserin aut In BMC Cancer BMC, 2003 12(2012), 1, p 426 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:12 year:2012 number:1, p 426 https://doi.org/10.1186/1471-2407-12-426 kostenfrei https://doaj.org/article/1762e31f2c9342efbe14b212152ef962 kostenfrei http://www.biomedcentral.com/1471-2407/12/426 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1, p 426
spelling	10.1186/1471-2407-12-426 doi (DE-627)DOAJ049129872 (DE-599)DOAJ1762e31f2c9342efbe14b212152ef962 DE-627 ger DE-627 rakwb eng RC254-282 Bøhn Siv K verfasserin aut Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p< Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Russnes Kjell M verfasserin aut Sakhi Amrit K verfasserin aut Thoresen Magne verfasserin aut Holden Marit verfasserin aut Moskaug JanØ verfasserin aut Myhrstad Mari C verfasserin aut Olstad Ole K verfasserin aut Smeland Sigbjørn verfasserin aut Blomhoff Rune verfasserin aut In BMC Cancer BMC, 2003 12(2012), 1, p 426 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:12 year:2012 number:1, p 426 https://doi.org/10.1186/1471-2407-12-426 kostenfrei https://doaj.org/article/1762e31f2c9342efbe14b212152ef962 kostenfrei http://www.biomedcentral.com/1471-2407/12/426 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1, p 426
allfields_unstemmed	10.1186/1471-2407-12-426 doi (DE-627)DOAJ049129872 (DE-599)DOAJ1762e31f2c9342efbe14b212152ef962 DE-627 ger DE-627 rakwb eng RC254-282 Bøhn Siv K verfasserin aut Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p< Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Russnes Kjell M verfasserin aut Sakhi Amrit K verfasserin aut Thoresen Magne verfasserin aut Holden Marit verfasserin aut Moskaug JanØ verfasserin aut Myhrstad Mari C verfasserin aut Olstad Ole K verfasserin aut Smeland Sigbjørn verfasserin aut Blomhoff Rune verfasserin aut In BMC Cancer BMC, 2003 12(2012), 1, p 426 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:12 year:2012 number:1, p 426 https://doi.org/10.1186/1471-2407-12-426 kostenfrei https://doaj.org/article/1762e31f2c9342efbe14b212152ef962 kostenfrei http://www.biomedcentral.com/1471-2407/12/426 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1, p 426
allfieldsGer	10.1186/1471-2407-12-426 doi (DE-627)DOAJ049129872 (DE-599)DOAJ1762e31f2c9342efbe14b212152ef962 DE-627 ger DE-627 rakwb eng RC254-282 Bøhn Siv K verfasserin aut Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p< Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Russnes Kjell M verfasserin aut Sakhi Amrit K verfasserin aut Thoresen Magne verfasserin aut Holden Marit verfasserin aut Moskaug JanØ verfasserin aut Myhrstad Mari C verfasserin aut Olstad Ole K verfasserin aut Smeland Sigbjørn verfasserin aut Blomhoff Rune verfasserin aut In BMC Cancer BMC, 2003 12(2012), 1, p 426 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:12 year:2012 number:1, p 426 https://doi.org/10.1186/1471-2407-12-426 kostenfrei https://doaj.org/article/1762e31f2c9342efbe14b212152ef962 kostenfrei http://www.biomedcentral.com/1471-2407/12/426 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1, p 426
allfieldsSound	10.1186/1471-2407-12-426 doi (DE-627)DOAJ049129872 (DE-599)DOAJ1762e31f2c9342efbe14b212152ef962 DE-627 ger DE-627 rakwb eng RC254-282 Bøhn Siv K verfasserin aut Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p< Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Russnes Kjell M verfasserin aut Sakhi Amrit K verfasserin aut Thoresen Magne verfasserin aut Holden Marit verfasserin aut Moskaug JanØ verfasserin aut Myhrstad Mari C verfasserin aut Olstad Ole K verfasserin aut Smeland Sigbjørn verfasserin aut Blomhoff Rune verfasserin aut In BMC Cancer BMC, 2003 12(2012), 1, p 426 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:12 year:2012 number:1, p 426 https://doi.org/10.1186/1471-2407-12-426 kostenfrei https://doaj.org/article/1762e31f2c9342efbe14b212152ef962 kostenfrei http://www.biomedcentral.com/1471-2407/12/426 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1, p 426
language	English
source	In BMC Cancer 12(2012), 1, p 426 volume:12 year:2012 number:1, p 426
sourceStr	In BMC Cancer 12(2012), 1, p 426 volume:12 year:2012 number:1, p 426
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Bøhn Siv K @@aut@@ Russnes Kjell M @@aut@@ Sakhi Amrit K @@aut@@ Thoresen Magne @@aut@@ Holden Marit @@aut@@ Moskaug JanØ @@aut@@ Myhrstad Mari C @@aut@@ Olstad Ole K @@aut@@ Smeland Sigbjørn @@aut@@ Blomhoff Rune @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ049129872
language_de	englisch
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callnumber-first	R - Medicine
author	Bøhn Siv K
spellingShingle	Bøhn Siv K misc RC254-282 misc Radiotherapy misc HNSCC misc Antioxidants misc Microarray misc GSEA misc Cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
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topic_title	RC254-282 Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients Radiotherapy HNSCC Antioxidants Microarray GSEA Cancer
topic	misc RC254-282 misc Radiotherapy misc HNSCC misc Antioxidants misc Microarray misc GSEA misc Cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Radiotherapy misc HNSCC misc Antioxidants misc Microarray misc GSEA misc Cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
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title_full	Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
author_sort	Bøhn Siv K
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author_browse	Bøhn Siv K Russnes Kjell M Sakhi Amrit K Thoresen Magne Holden Marit Moskaug JanØ Myhrstad Mari C Olstad Ole K Smeland Sigbjørn Blomhoff Rune
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title_sort	stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
callnumber	RC254-282
title_auth	Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
abstract	<p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy.</p< <p<Methods</p< <p<Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis.</p< <p<Results</p< <p<There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716).</p< <p<Conclusions</p< <p<Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.</p< <p<Trial registration</p< <p<Raw data are available at ArrayExpress under accession number E-MEXP-2460.</p<
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title_short	Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
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Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

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