Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster

The centrosome is the best-understood microtubule-organizing center (MTOC) and is essential in particular cell types and at specific stages during Drosophila development. The centrosome is not required zygotically for mitosis or to achieve full animal development. Nevertheless, centrosomes are essen...
Ausführliche Beschreibung

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Autor*in:	Marisa M. L. Tillery [verfasserIn] Caitlyn Blake-Hedges [verfasserIn] Yiming Zheng [verfasserIn] Rebecca A. Buchwalter [verfasserIn] Timothy L. Megraw [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	centrosome centriole Drosophila microtubule-organizing center (MTOC) non-centrosomal MTOC ninein patronin γ-tubulin microtubule

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 7(2018), 9, p 121
Übergeordnetes Werk:	volume:7 ; year:2018 ; number:9, p 121

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells7090121

Katalog-ID:	DOAJ049182951

Internformat


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authorswithroles_txt_mv	Marisa M. L. Tillery @@aut@@ Caitlyn Blake-Hedges @@aut@@ Yiming Zheng @@aut@@ Rebecca A. Buchwalter @@aut@@ Timothy L. Megraw @@aut@@
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callnumber-first	Q - Science
author	Marisa M. L. Tillery
spellingShingle	Marisa M. L. Tillery misc QH301-705.5 misc centrosome misc centriole misc Drosophila misc microtubule-organizing center (MTOC) misc non-centrosomal MTOC misc ninein misc patronin misc γ-tubulin misc microtubule misc Biology (General) Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
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topic_title	QH301-705.5 Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster centrosome centriole Drosophila microtubule-organizing center (MTOC) non-centrosomal MTOC ninein patronin γ-tubulin microtubule
topic	misc QH301-705.5 misc centrosome misc centriole misc Drosophila misc microtubule-organizing center (MTOC) misc non-centrosomal MTOC misc ninein misc patronin misc γ-tubulin misc microtubule misc Biology (General)
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title	Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
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title_full	Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
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author_browse	Marisa M. L. Tillery Caitlyn Blake-Hedges Yiming Zheng Rebecca A. Buchwalter Timothy L. Megraw
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title_sort	centrosomal and non-centrosomal microtubule-organizing centers (mtocs) in drosophila melanogaster
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title_auth	Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
abstract	The centrosome is the best-understood microtubule-organizing center (MTOC) and is essential in particular cell types and at specific stages during Drosophila development. The centrosome is not required zygotically for mitosis or to achieve full animal development. Nevertheless, centrosomes are essential maternally during cleavage cycles in the early embryo, for male meiotic divisions, for efficient division of epithelial cells in the imaginal wing disc, and for cilium/flagellum assembly in sensory neurons and spermatozoa. Importantly, asymmetric and polarized division of stem cells is regulated by centrosomes and by the asymmetric regulation of their microtubule (MT) assembly activity. More recently, the components and functions of a variety of non-centrosomal microtubule-organizing centers (ncMTOCs) have begun to be elucidated. Throughout Drosophila development, a wide variety of unique ncMTOCs form in epithelial and non-epithelial cell types at an assortment of subcellular locations. Some of these cell types also utilize the centrosomal MTOC, while others rely exclusively on ncMTOCs. The impressive variety of ncMTOCs being discovered provides novel insight into the diverse functions of MTOCs in cells and tissues. This review highlights our current knowledge of the composition, assembly, and functional roles of centrosomal and non-centrosomal MTOCs in Drosophila.
abstractGer	The centrosome is the best-understood microtubule-organizing center (MTOC) and is essential in particular cell types and at specific stages during Drosophila development. The centrosome is not required zygotically for mitosis or to achieve full animal development. Nevertheless, centrosomes are essential maternally during cleavage cycles in the early embryo, for male meiotic divisions, for efficient division of epithelial cells in the imaginal wing disc, and for cilium/flagellum assembly in sensory neurons and spermatozoa. Importantly, asymmetric and polarized division of stem cells is regulated by centrosomes and by the asymmetric regulation of their microtubule (MT) assembly activity. More recently, the components and functions of a variety of non-centrosomal microtubule-organizing centers (ncMTOCs) have begun to be elucidated. Throughout Drosophila development, a wide variety of unique ncMTOCs form in epithelial and non-epithelial cell types at an assortment of subcellular locations. Some of these cell types also utilize the centrosomal MTOC, while others rely exclusively on ncMTOCs. The impressive variety of ncMTOCs being discovered provides novel insight into the diverse functions of MTOCs in cells and tissues. This review highlights our current knowledge of the composition, assembly, and functional roles of centrosomal and non-centrosomal MTOCs in Drosophila.
abstract_unstemmed	The centrosome is the best-understood microtubule-organizing center (MTOC) and is essential in particular cell types and at specific stages during Drosophila development. The centrosome is not required zygotically for mitosis or to achieve full animal development. Nevertheless, centrosomes are essential maternally during cleavage cycles in the early embryo, for male meiotic divisions, for efficient division of epithelial cells in the imaginal wing disc, and for cilium/flagellum assembly in sensory neurons and spermatozoa. Importantly, asymmetric and polarized division of stem cells is regulated by centrosomes and by the asymmetric regulation of their microtubule (MT) assembly activity. More recently, the components and functions of a variety of non-centrosomal microtubule-organizing centers (ncMTOCs) have begun to be elucidated. Throughout Drosophila development, a wide variety of unique ncMTOCs form in epithelial and non-epithelial cell types at an assortment of subcellular locations. Some of these cell types also utilize the centrosomal MTOC, while others rely exclusively on ncMTOCs. The impressive variety of ncMTOCs being discovered provides novel insight into the diverse functions of MTOCs in cells and tissues. This review highlights our current knowledge of the composition, assembly, and functional roles of centrosomal and non-centrosomal MTOCs in Drosophila.
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container_issue	9, p 121
title_short	Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
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Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster

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