Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy

Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxa...
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Autor*in:	Won Kyung Cho [verfasserIn] Jee Suk Chang [verfasserIn] Seung Gyu Park [verfasserIn] Nalee Kim [verfasserIn] Doo Ho Choi [verfasserIn] Haeyoung Kim [verfasserIn] Yong Bae Kim [verfasserIn] Won Park [verfasserIn] Chang Ok Suh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Regional lymph node irradiation Internal mammary node Radiation

Übergeordnetes Werk:	In: Breast - Elsevier, 2020, 59(2021), Seite 37-43
Übergeordnetes Werk:	volume:59 ; year:2021 ; pages:37-43

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.breast.2021.05.012

Katalog-ID:	DOAJ049309056

Internformat


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520			\|a Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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700	0		\|a Won Park \|e verfasserin \|4 aut
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allfields	10.1016/j.breast.2021.05.012 doi (DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874 DE-627 ger DE-627 rakwb eng RC254-282 Won Kyung Cho verfasserin aut Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jee Suk Chang verfasserin aut Seung Gyu Park verfasserin aut Nalee Kim verfasserin aut Doo Ho Choi verfasserin aut Haeyoung Kim verfasserin aut Yong Bae Kim verfasserin aut Won Park verfasserin aut Chang Ok Suh verfasserin aut In Breast Elsevier, 2020 59(2021), Seite 37-43 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:59 year:2021 pages:37-43 https://doi.org/10.1016/j.breast.2021.05.012 kostenfrei https://doaj.org/article/e212964157fa4029b4b9f721f132b874 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977621003842 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 59 2021 37-43
spelling	10.1016/j.breast.2021.05.012 doi (DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874 DE-627 ger DE-627 rakwb eng RC254-282 Won Kyung Cho verfasserin aut Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jee Suk Chang verfasserin aut Seung Gyu Park verfasserin aut Nalee Kim verfasserin aut Doo Ho Choi verfasserin aut Haeyoung Kim verfasserin aut Yong Bae Kim verfasserin aut Won Park verfasserin aut Chang Ok Suh verfasserin aut In Breast Elsevier, 2020 59(2021), Seite 37-43 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:59 year:2021 pages:37-43 https://doi.org/10.1016/j.breast.2021.05.012 kostenfrei https://doaj.org/article/e212964157fa4029b4b9f721f132b874 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977621003842 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 59 2021 37-43
allfields_unstemmed	10.1016/j.breast.2021.05.012 doi (DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874 DE-627 ger DE-627 rakwb eng RC254-282 Won Kyung Cho verfasserin aut Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jee Suk Chang verfasserin aut Seung Gyu Park verfasserin aut Nalee Kim verfasserin aut Doo Ho Choi verfasserin aut Haeyoung Kim verfasserin aut Yong Bae Kim verfasserin aut Won Park verfasserin aut Chang Ok Suh verfasserin aut In Breast Elsevier, 2020 59(2021), Seite 37-43 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:59 year:2021 pages:37-43 https://doi.org/10.1016/j.breast.2021.05.012 kostenfrei https://doaj.org/article/e212964157fa4029b4b9f721f132b874 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977621003842 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 59 2021 37-43
allfieldsGer	10.1016/j.breast.2021.05.012 doi (DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874 DE-627 ger DE-627 rakwb eng RC254-282 Won Kyung Cho verfasserin aut Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jee Suk Chang verfasserin aut Seung Gyu Park verfasserin aut Nalee Kim verfasserin aut Doo Ho Choi verfasserin aut Haeyoung Kim verfasserin aut Yong Bae Kim verfasserin aut Won Park verfasserin aut Chang Ok Suh verfasserin aut In Breast Elsevier, 2020 59(2021), Seite 37-43 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:59 year:2021 pages:37-43 https://doi.org/10.1016/j.breast.2021.05.012 kostenfrei https://doaj.org/article/e212964157fa4029b4b9f721f132b874 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977621003842 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 59 2021 37-43
allfieldsSound	10.1016/j.breast.2021.05.012 doi (DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874 DE-627 ger DE-627 rakwb eng RC254-282 Won Kyung Cho verfasserin aut Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jee Suk Chang verfasserin aut Seung Gyu Park verfasserin aut Nalee Kim verfasserin aut Doo Ho Choi verfasserin aut Haeyoung Kim verfasserin aut Yong Bae Kim verfasserin aut Won Park verfasserin aut Chang Ok Suh verfasserin aut In Breast Elsevier, 2020 59(2021), Seite 37-43 (DE-627)320475042 (DE-600)2009043-2 15323080 nnns volume:59 year:2021 pages:37-43 https://doi.org/10.1016/j.breast.2021.05.012 kostenfrei https://doaj.org/article/e212964157fa4029b4b9f721f132b874 kostenfrei http://www.sciencedirect.com/science/article/pii/S0960977621003842 kostenfrei https://doaj.org/toc/1532-3080 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 59 2021 37-43
language	English
source	In Breast 59(2021), Seite 37-43 volume:59 year:2021 pages:37-43
sourceStr	In Breast 59(2021), Seite 37-43 volume:59 year:2021 pages:37-43
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Regional lymph node irradiation Internal mammary node Radiation Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Breast
authorswithroles_txt_mv	Won Kyung Cho @@aut@@ Jee Suk Chang @@aut@@ Seung Gyu Park @@aut@@ Nalee Kim @@aut@@ Doo Ho Choi @@aut@@ Haeyoung Kim @@aut@@ Yong Bae Kim @@aut@@ Won Park @@aut@@ Chang Ok Suh @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	320475042
id	DOAJ049309056
language_de	englisch
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We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Regional lymph node irradiation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Internal mammary node</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Radiation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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callnumber-first	R - Medicine
author	Won Kyung Cho
spellingShingle	Won Kyung Cho misc RC254-282 misc Regional lymph node irradiation misc Internal mammary node misc Radiation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
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topic_title	RC254-282 Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy Regional lymph node irradiation Internal mammary node Radiation
topic	misc RC254-282 misc Regional lymph node irradiation misc Internal mammary node misc Radiation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Regional lymph node irradiation misc Internal mammary node misc Radiation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Regional lymph node irradiation misc Internal mammary node misc Radiation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
ctrlnum	(DE-627)DOAJ049309056 (DE-599)DOAJe212964157fa4029b4b9f721f132b874
title_full	Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
author_sort	Won Kyung Cho
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author_browse	Won Kyung Cho Jee Suk Chang Seung Gyu Park Nalee Kim Doo Ho Choi Haeyoung Kim Yong Bae Kim Won Park Chang Ok Suh
container_volume	59
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Won Kyung Cho
doi_str_mv	10.1016/j.breast.2021.05.012
author2-role	verfasserin
title_sort	internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
callnumber	RC254-282
title_auth	Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
abstract	Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.
abstractGer	Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.
abstract_unstemmed	Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.
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title_short	Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
url	https://doi.org/10.1016/j.breast.2021.05.012 https://doaj.org/article/e212964157fa4029b4b9f721f132b874 http://www.sciencedirect.com/science/article/pii/S0960977621003842 https://doaj.org/toc/1532-3080
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up_date	2024-07-03T22:39:04.551Z
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Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy

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