Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD

Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (...
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Autor*in:	Ziad A. Massy [verfasserIn] Jean Ferrières [verfasserIn] Eric Bruckert [verfasserIn] Céline Lange [verfasserIn] Sophie Liabeuf [verfasserIn] Maja Velkovski-Rouyer [verfasserIn] Bénédicte Stengel [verfasserIn] Carole Ayav [verfasserIn] Christian Combe [verfasserIn] Denis Fouque [verfasserIn] Luc Frimat [verfasserIn] Yves-Edouard Herpe [verfasserIn] Maurice Laville [verfasserIn] Ziad Massy [verfasserIn] Karine Legrand [verfasserIn] Marie Metzger [verfasserIn] Elodie Speyer [verfasserIn] Bruno Moulin [verfasserIn] Gaétan Lebrun [verfasserIn] Éric Magnant [verfasserIn] Gabriel Choukroun [verfasserIn] Jean Philippe Bourdenx [verfasserIn] Marie Essig [verfasserIn] Raymond Azar [verfasserIn] Mustafa Smati [verfasserIn] Mohamed Jamali [verfasserIn] Alexandre Klein [verfasserIn] Michel Delahousse [verfasserIn] Séverine Martin [verfasserIn] Eric Thervet [verfasserIn] Xavier Belenfant [verfasserIn] Pablo Urena [verfasserIn] Carlos Vela [verfasserIn] Dominique Chauveau [verfasserIn] Viktor Panescu [verfasserIn] François Glowacki [verfasserIn] Maxime Hoffmann [verfasserIn] Maryvonne Hourmant [verfasserIn] Dominique Besnier [verfasserIn] Angelo Testa [verfasserIn] Philippe Zaoui [verfasserIn] Charles Chazot [verfasserIn] Laurent Juillard [verfasserIn] Stéphane Burtey [verfasserIn] Adrien Keller [verfasserIn] Nassim Kamar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Kidney International Reports - Elsevier, 2016, 4(2019), 11, Seite 1546-1554
Übergeordnetes Werk:	volume:4 ; year:2019 ; number:11 ; pages:1546-1554

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ekir.2019.07.014

Katalog-ID:	DOAJ049324918

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520			\|a Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol
653		0	\|a Diseases of the genitourinary system. Urology
700	0		\|a Jean Ferrières \|e verfasserin \|4 aut
700	0		\|a Eric Bruckert \|e verfasserin \|4 aut
700	0		\|a Céline Lange \|e verfasserin \|4 aut
700	0		\|a Sophie Liabeuf \|e verfasserin \|4 aut
700	0		\|a Maja Velkovski-Rouyer \|e verfasserin \|4 aut
700	0		\|a Bénédicte Stengel \|e verfasserin \|4 aut
700	0		\|a Carole Ayav \|e verfasserin \|4 aut
700	0		\|a Christian Combe \|e verfasserin \|4 aut
700	0		\|a Denis Fouque \|e verfasserin \|4 aut
700	0		\|a Luc Frimat \|e verfasserin \|4 aut
700	0		\|a Yves-Edouard Herpe \|e verfasserin \|4 aut
700	0		\|a Maurice Laville \|e verfasserin \|4 aut
700	0		\|a Ziad Massy \|e verfasserin \|4 aut
700	0		\|a Bénédicte Stengel \|e verfasserin \|4 aut
700	0		\|a Céline Lange \|e verfasserin \|4 aut
700	0		\|a Karine Legrand \|e verfasserin \|4 aut
700	0		\|a Sophie Liabeuf \|e verfasserin \|4 aut
700	0		\|a Marie Metzger \|e verfasserin \|4 aut
700	0		\|a Elodie Speyer \|e verfasserin \|4 aut
700	0		\|a Bruno Moulin \|e verfasserin \|4 aut
700	0		\|a Gaétan Lebrun \|e verfasserin \|4 aut
700	0		\|a Éric Magnant \|e verfasserin \|4 aut
700	0		\|a Gabriel Choukroun \|e verfasserin \|4 aut
700	0		\|a Jean Philippe Bourdenx \|e verfasserin \|4 aut
700	0		\|a Marie Essig \|e verfasserin \|4 aut
700	0		\|a Raymond Azar \|e verfasserin \|4 aut
700	0		\|a Mustafa Smati \|e verfasserin \|4 aut
700	0		\|a Mohamed Jamali \|e verfasserin \|4 aut
700	0		\|a Alexandre Klein \|e verfasserin \|4 aut
700	0		\|a Michel Delahousse \|e verfasserin \|4 aut
700	0		\|a Christian Combe \|e verfasserin \|4 aut
700	0		\|a Séverine Martin \|e verfasserin \|4 aut
700	0		\|a Eric Thervet \|e verfasserin \|4 aut
700	0		\|a Ziad Massy \|e verfasserin \|4 aut
700	0		\|a Xavier Belenfant \|e verfasserin \|4 aut
700	0		\|a Pablo Urena \|e verfasserin \|4 aut
700	0		\|a Carlos Vela \|e verfasserin \|4 aut
700	0		\|a Luc Frimat \|e verfasserin \|4 aut
700	0		\|a Dominique Chauveau \|e verfasserin \|4 aut
700	0		\|a Viktor Panescu \|e verfasserin \|4 aut
700	0		\|a François Glowacki \|e verfasserin \|4 aut
700	0		\|a Maxime Hoffmann \|e verfasserin \|4 aut
700	0		\|a Maryvonne Hourmant \|e verfasserin \|4 aut
700	0		\|a Dominique Besnier \|e verfasserin \|4 aut
700	0		\|a Angelo Testa \|e verfasserin \|4 aut
700	0		\|a Philippe Zaoui \|e verfasserin \|4 aut
700	0		\|a Charles Chazot \|e verfasserin \|4 aut
700	0		\|a Laurent Juillard \|e verfasserin \|4 aut
700	0		\|a Stéphane Burtey \|e verfasserin \|4 aut
700	0		\|a Adrien Keller \|e verfasserin \|4 aut
700	0		\|a Nassim Kamar \|e verfasserin \|4 aut
700	0		\|a Denis Fouque \|e verfasserin \|4 aut
700	0		\|a Maurice Laville \|e verfasserin \|4 aut
773	0	8	\|i In \|t Kidney International Reports \|d Elsevier, 2016 \|g 4(2019), 11, Seite 1546-1554 \|w (DE-627)881695580 \|w (DE-600)2887223-X \|x 24680249 \|7 nnns
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856	4	0	\|u http://www.sciencedirect.com/science/article/pii/S2468024919314354 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2468-0249 \|y Journal toc \|z kostenfrei
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author_variant	z a m zam j f jf e b eb c l cl s l sl m v r mvr b s bs c a ca c c cc d f df l f lf y e h yeh m l ml z m zm b s bs c l cl k l kl s l sl m m mm e s es b m bm g l gl é m ém g c gc j p b jpb m e me r a ra m s ms m j mj a k ak m d md c c cc s m sm e t et z m zm x b xb p u pu c v cv l f lf d c dc v p vp f g fg m h mh m h mh d b db a t at p z pz c c cc l j lj s b sb a k ak n k nk d f df m l ml
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publishDate	2019
allfields	10.1016/j.ekir.2019.07.014 doi (DE-627)DOAJ049324918 (DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401 DE-627 ger DE-627 rakwb eng RC870-923 Ziad A. Massy verfasserin aut Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol Diseases of the genitourinary system. Urology Jean Ferrières verfasserin aut Eric Bruckert verfasserin aut Céline Lange verfasserin aut Sophie Liabeuf verfasserin aut Maja Velkovski-Rouyer verfasserin aut Bénédicte Stengel verfasserin aut Carole Ayav verfasserin aut Christian Combe verfasserin aut Denis Fouque verfasserin aut Luc Frimat verfasserin aut Yves-Edouard Herpe verfasserin aut Maurice Laville verfasserin aut Ziad Massy verfasserin aut Bénédicte Stengel verfasserin aut Céline Lange verfasserin aut Karine Legrand verfasserin aut Sophie Liabeuf verfasserin aut Marie Metzger verfasserin aut Elodie Speyer verfasserin aut Bruno Moulin verfasserin aut Gaétan Lebrun verfasserin aut Éric Magnant verfasserin aut Gabriel Choukroun verfasserin aut Jean Philippe Bourdenx verfasserin aut Marie Essig verfasserin aut Raymond Azar verfasserin aut Mustafa Smati verfasserin aut Mohamed Jamali verfasserin aut Alexandre Klein verfasserin aut Michel Delahousse verfasserin aut Christian Combe verfasserin aut Séverine Martin verfasserin aut Eric Thervet verfasserin aut Ziad Massy verfasserin aut Xavier Belenfant verfasserin aut Pablo Urena verfasserin aut Carlos Vela verfasserin aut Luc Frimat verfasserin aut Dominique Chauveau verfasserin aut Viktor Panescu verfasserin aut François Glowacki verfasserin aut Maxime Hoffmann verfasserin aut Maryvonne Hourmant verfasserin aut Dominique Besnier verfasserin aut Angelo Testa verfasserin aut Philippe Zaoui verfasserin aut Charles Chazot verfasserin aut Laurent Juillard verfasserin aut Stéphane Burtey verfasserin aut Adrien Keller verfasserin aut Nassim Kamar verfasserin aut Denis Fouque verfasserin aut Maurice Laville verfasserin aut In Kidney International Reports Elsevier, 2016 4(2019), 11, Seite 1546-1554 (DE-627)881695580 (DE-600)2887223-X 24680249 nnns volume:4 year:2019 number:11 pages:1546-1554 https://doi.org/10.1016/j.ekir.2019.07.014 kostenfrei https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468024919314354 kostenfrei https://doaj.org/toc/2468-0249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2019 11 1546-1554
spelling	10.1016/j.ekir.2019.07.014 doi (DE-627)DOAJ049324918 (DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401 DE-627 ger DE-627 rakwb eng RC870-923 Ziad A. Massy verfasserin aut Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol Diseases of the genitourinary system. Urology Jean Ferrières verfasserin aut Eric Bruckert verfasserin aut Céline Lange verfasserin aut Sophie Liabeuf verfasserin aut Maja Velkovski-Rouyer verfasserin aut Bénédicte Stengel verfasserin aut Carole Ayav verfasserin aut Christian Combe verfasserin aut Denis Fouque verfasserin aut Luc Frimat verfasserin aut Yves-Edouard Herpe verfasserin aut Maurice Laville verfasserin aut Ziad Massy verfasserin aut Bénédicte Stengel verfasserin aut Céline Lange verfasserin aut Karine Legrand verfasserin aut Sophie Liabeuf verfasserin aut Marie Metzger verfasserin aut Elodie Speyer verfasserin aut Bruno Moulin verfasserin aut Gaétan Lebrun verfasserin aut Éric Magnant verfasserin aut Gabriel Choukroun verfasserin aut Jean Philippe Bourdenx verfasserin aut Marie Essig verfasserin aut Raymond Azar verfasserin aut Mustafa Smati verfasserin aut Mohamed Jamali verfasserin aut Alexandre Klein verfasserin aut Michel Delahousse verfasserin aut Christian Combe verfasserin aut Séverine Martin verfasserin aut Eric Thervet verfasserin aut Ziad Massy verfasserin aut Xavier Belenfant verfasserin aut Pablo Urena verfasserin aut Carlos Vela verfasserin aut Luc Frimat verfasserin aut Dominique Chauveau verfasserin aut Viktor Panescu verfasserin aut François Glowacki verfasserin aut Maxime Hoffmann verfasserin aut Maryvonne Hourmant verfasserin aut Dominique Besnier verfasserin aut Angelo Testa verfasserin aut Philippe Zaoui verfasserin aut Charles Chazot verfasserin aut Laurent Juillard verfasserin aut Stéphane Burtey verfasserin aut Adrien Keller verfasserin aut Nassim Kamar verfasserin aut Denis Fouque verfasserin aut Maurice Laville verfasserin aut In Kidney International Reports Elsevier, 2016 4(2019), 11, Seite 1546-1554 (DE-627)881695580 (DE-600)2887223-X 24680249 nnns volume:4 year:2019 number:11 pages:1546-1554 https://doi.org/10.1016/j.ekir.2019.07.014 kostenfrei https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468024919314354 kostenfrei https://doaj.org/toc/2468-0249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2019 11 1546-1554
allfields_unstemmed	10.1016/j.ekir.2019.07.014 doi (DE-627)DOAJ049324918 (DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401 DE-627 ger DE-627 rakwb eng RC870-923 Ziad A. Massy verfasserin aut Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol Diseases of the genitourinary system. Urology Jean Ferrières verfasserin aut Eric Bruckert verfasserin aut Céline Lange verfasserin aut Sophie Liabeuf verfasserin aut Maja Velkovski-Rouyer verfasserin aut Bénédicte Stengel verfasserin aut Carole Ayav verfasserin aut Christian Combe verfasserin aut Denis Fouque verfasserin aut Luc Frimat verfasserin aut Yves-Edouard Herpe verfasserin aut Maurice Laville verfasserin aut Ziad Massy verfasserin aut Bénédicte Stengel verfasserin aut Céline Lange verfasserin aut Karine Legrand verfasserin aut Sophie Liabeuf verfasserin aut Marie Metzger verfasserin aut Elodie Speyer verfasserin aut Bruno Moulin verfasserin aut Gaétan Lebrun verfasserin aut Éric Magnant verfasserin aut Gabriel Choukroun verfasserin aut Jean Philippe Bourdenx verfasserin aut Marie Essig verfasserin aut Raymond Azar verfasserin aut Mustafa Smati verfasserin aut Mohamed Jamali verfasserin aut Alexandre Klein verfasserin aut Michel Delahousse verfasserin aut Christian Combe verfasserin aut Séverine Martin verfasserin aut Eric Thervet verfasserin aut Ziad Massy verfasserin aut Xavier Belenfant verfasserin aut Pablo Urena verfasserin aut Carlos Vela verfasserin aut Luc Frimat verfasserin aut Dominique Chauveau verfasserin aut Viktor Panescu verfasserin aut François Glowacki verfasserin aut Maxime Hoffmann verfasserin aut Maryvonne Hourmant verfasserin aut Dominique Besnier verfasserin aut Angelo Testa verfasserin aut Philippe Zaoui verfasserin aut Charles Chazot verfasserin aut Laurent Juillard verfasserin aut Stéphane Burtey verfasserin aut Adrien Keller verfasserin aut Nassim Kamar verfasserin aut Denis Fouque verfasserin aut Maurice Laville verfasserin aut In Kidney International Reports Elsevier, 2016 4(2019), 11, Seite 1546-1554 (DE-627)881695580 (DE-600)2887223-X 24680249 nnns volume:4 year:2019 number:11 pages:1546-1554 https://doi.org/10.1016/j.ekir.2019.07.014 kostenfrei https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468024919314354 kostenfrei https://doaj.org/toc/2468-0249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2019 11 1546-1554
allfieldsGer	10.1016/j.ekir.2019.07.014 doi (DE-627)DOAJ049324918 (DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401 DE-627 ger DE-627 rakwb eng RC870-923 Ziad A. Massy verfasserin aut Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol Diseases of the genitourinary system. Urology Jean Ferrières verfasserin aut Eric Bruckert verfasserin aut Céline Lange verfasserin aut Sophie Liabeuf verfasserin aut Maja Velkovski-Rouyer verfasserin aut Bénédicte Stengel verfasserin aut Carole Ayav verfasserin aut Christian Combe verfasserin aut Denis Fouque verfasserin aut Luc Frimat verfasserin aut Yves-Edouard Herpe verfasserin aut Maurice Laville verfasserin aut Ziad Massy verfasserin aut Bénédicte Stengel verfasserin aut Céline Lange verfasserin aut Karine Legrand verfasserin aut Sophie Liabeuf verfasserin aut Marie Metzger verfasserin aut Elodie Speyer verfasserin aut Bruno Moulin verfasserin aut Gaétan Lebrun verfasserin aut Éric Magnant verfasserin aut Gabriel Choukroun verfasserin aut Jean Philippe Bourdenx verfasserin aut Marie Essig verfasserin aut Raymond Azar verfasserin aut Mustafa Smati verfasserin aut Mohamed Jamali verfasserin aut Alexandre Klein verfasserin aut Michel Delahousse verfasserin aut Christian Combe verfasserin aut Séverine Martin verfasserin aut Eric Thervet verfasserin aut Ziad Massy verfasserin aut Xavier Belenfant verfasserin aut Pablo Urena verfasserin aut Carlos Vela verfasserin aut Luc Frimat verfasserin aut Dominique Chauveau verfasserin aut Viktor Panescu verfasserin aut François Glowacki verfasserin aut Maxime Hoffmann verfasserin aut Maryvonne Hourmant verfasserin aut Dominique Besnier verfasserin aut Angelo Testa verfasserin aut Philippe Zaoui verfasserin aut Charles Chazot verfasserin aut Laurent Juillard verfasserin aut Stéphane Burtey verfasserin aut Adrien Keller verfasserin aut Nassim Kamar verfasserin aut Denis Fouque verfasserin aut Maurice Laville verfasserin aut In Kidney International Reports Elsevier, 2016 4(2019), 11, Seite 1546-1554 (DE-627)881695580 (DE-600)2887223-X 24680249 nnns volume:4 year:2019 number:11 pages:1546-1554 https://doi.org/10.1016/j.ekir.2019.07.014 kostenfrei https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468024919314354 kostenfrei https://doaj.org/toc/2468-0249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2019 11 1546-1554
allfieldsSound	10.1016/j.ekir.2019.07.014 doi (DE-627)DOAJ049324918 (DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401 DE-627 ger DE-627 rakwb eng RC870-923 Ziad A. Massy verfasserin aut Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol Diseases of the genitourinary system. Urology Jean Ferrières verfasserin aut Eric Bruckert verfasserin aut Céline Lange verfasserin aut Sophie Liabeuf verfasserin aut Maja Velkovski-Rouyer verfasserin aut Bénédicte Stengel verfasserin aut Carole Ayav verfasserin aut Christian Combe verfasserin aut Denis Fouque verfasserin aut Luc Frimat verfasserin aut Yves-Edouard Herpe verfasserin aut Maurice Laville verfasserin aut Ziad Massy verfasserin aut Bénédicte Stengel verfasserin aut Céline Lange verfasserin aut Karine Legrand verfasserin aut Sophie Liabeuf verfasserin aut Marie Metzger verfasserin aut Elodie Speyer verfasserin aut Bruno Moulin verfasserin aut Gaétan Lebrun verfasserin aut Éric Magnant verfasserin aut Gabriel Choukroun verfasserin aut Jean Philippe Bourdenx verfasserin aut Marie Essig verfasserin aut Raymond Azar verfasserin aut Mustafa Smati verfasserin aut Mohamed Jamali verfasserin aut Alexandre Klein verfasserin aut Michel Delahousse verfasserin aut Christian Combe verfasserin aut Séverine Martin verfasserin aut Eric Thervet verfasserin aut Ziad Massy verfasserin aut Xavier Belenfant verfasserin aut Pablo Urena verfasserin aut Carlos Vela verfasserin aut Luc Frimat verfasserin aut Dominique Chauveau verfasserin aut Viktor Panescu verfasserin aut François Glowacki verfasserin aut Maxime Hoffmann verfasserin aut Maryvonne Hourmant verfasserin aut Dominique Besnier verfasserin aut Angelo Testa verfasserin aut Philippe Zaoui verfasserin aut Charles Chazot verfasserin aut Laurent Juillard verfasserin aut Stéphane Burtey verfasserin aut Adrien Keller verfasserin aut Nassim Kamar verfasserin aut Denis Fouque verfasserin aut Maurice Laville verfasserin aut In Kidney International Reports Elsevier, 2016 4(2019), 11, Seite 1546-1554 (DE-627)881695580 (DE-600)2887223-X 24680249 nnns volume:4 year:2019 number:11 pages:1546-1554 https://doi.org/10.1016/j.ekir.2019.07.014 kostenfrei https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468024919314354 kostenfrei https://doaj.org/toc/2468-0249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2019 11 1546-1554
language	English
source	In Kidney International Reports 4(2019), 11, Seite 1546-1554 volume:4 year:2019 number:11 pages:1546-1554
sourceStr	In Kidney International Reports 4(2019), 11, Seite 1546-1554 volume:4 year:2019 number:11 pages:1546-1554
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the genitourinary system. Urology
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container_title	Kidney International Reports
authorswithroles_txt_mv	Ziad A. Massy @@aut@@ Jean Ferrières @@aut@@ Eric Bruckert @@aut@@ Céline Lange @@aut@@ Sophie Liabeuf @@aut@@ Maja Velkovski-Rouyer @@aut@@ Bénédicte Stengel @@aut@@ Carole Ayav @@aut@@ Christian Combe @@aut@@ Denis Fouque @@aut@@ Luc Frimat @@aut@@ Yves-Edouard Herpe @@aut@@ Maurice Laville @@aut@@ Ziad Massy @@aut@@ Karine Legrand @@aut@@ Marie Metzger @@aut@@ Elodie Speyer @@aut@@ Bruno Moulin @@aut@@ Gaétan Lebrun @@aut@@ Éric Magnant @@aut@@ Gabriel Choukroun @@aut@@ Jean Philippe Bourdenx @@aut@@ Marie Essig @@aut@@ Raymond Azar @@aut@@ Mustafa Smati @@aut@@ Mohamed Jamali @@aut@@ Alexandre Klein @@aut@@ Michel Delahousse @@aut@@ Séverine Martin @@aut@@ Eric Thervet @@aut@@ Xavier Belenfant @@aut@@ Pablo Urena @@aut@@ Carlos Vela @@aut@@ Dominique Chauveau @@aut@@ Viktor Panescu @@aut@@ François Glowacki @@aut@@ Maxime Hoffmann @@aut@@ Maryvonne Hourmant @@aut@@ Dominique Besnier @@aut@@ Angelo Testa @@aut@@ Philippe Zaoui @@aut@@ Charles Chazot @@aut@@ Laurent Juillard @@aut@@ Stéphane Burtey @@aut@@ Adrien Keller @@aut@@ Nassim Kamar @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	881695580
id	DOAJ049324918
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ049324918</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308142626.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ekir.2019.07.014</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ049324918</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ2e2d670b48f24d0da27d45f04c41f401</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC870-923</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Ziad A. Massy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the genitourinary system. 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callnumber-first	R - Medicine
author	Ziad A. Massy
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topic_title	RC870-923 Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD
topic	misc RC870-923 misc Diseases of the genitourinary system. Urology
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title	Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD
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title_full	Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD
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author_browse	Ziad A. Massy Jean Ferrières Eric Bruckert Céline Lange Sophie Liabeuf Maja Velkovski-Rouyer Bénédicte Stengel Carole Ayav Christian Combe Denis Fouque Luc Frimat Yves-Edouard Herpe Maurice Laville Ziad Massy Karine Legrand Marie Metzger Elodie Speyer Bruno Moulin Gaétan Lebrun Éric Magnant Gabriel Choukroun Jean Philippe Bourdenx Marie Essig Raymond Azar Mustafa Smati Mohamed Jamali Alexandre Klein Michel Delahousse Séverine Martin Eric Thervet Xavier Belenfant Pablo Urena Carlos Vela Dominique Chauveau Viktor Panescu François Glowacki Maxime Hoffmann Maryvonne Hourmant Dominique Besnier Angelo Testa Philippe Zaoui Charles Chazot Laurent Juillard Stéphane Burtey Adrien Keller Nassim Kamar
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doi_str_mv	10.1016/j.ekir.2019.07.014
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title_sort	achievement of low-density lipoprotein cholesterol targets in ckd
callnumber	RC870-923
title_auth	Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD
abstract	Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol
abstractGer	Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol
abstract_unstemmed	Introduction: We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. Methods: CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Results: Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (<2.6 mmol/l). Among very high-risk patients, the percentage at goal (<1.8 mmol/l) was 38% for CKD stage G3 and 29% for stage G4/5. There was a trend toward higher achievement of LDL-C targets with increasing LLT intensity (adjusted odds ratios for moderate vs. low intensity 1.20; 95% confidence interval 0.92–1.56; high vs. low intensity 1.46; 1.02–2.09; Ptrend = 0.036). Conclusion: Many patients with CKD stage G3−G5 who are eligible for LLT are not treated, and those on LLT rarely achieve LDL-C targets. Keywords: cardiovascular disease, chronic kidney diseases, lipid-regulating agents, lipids, low-density lipoprotein cholesterol
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title_short	Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD
url	https://doi.org/10.1016/j.ekir.2019.07.014 https://doaj.org/article/2e2d670b48f24d0da27d45f04c41f401 http://www.sciencedirect.com/science/article/pii/S2468024919314354 https://doaj.org/toc/2468-0249
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author2	Jean Ferrières Eric Bruckert Céline Lange Sophie Liabeuf Maja Velkovski-Rouyer Bénédicte Stengel Carole Ayav Christian Combe Denis Fouque Luc Frimat Yves-Edouard Herpe Maurice Laville Ziad Massy Karine Legrand Marie Metzger Elodie Speyer Bruno Moulin Gaétan Lebrun Éric Magnant Gabriel Choukroun Jean Philippe Bourdenx Marie Essig Raymond Azar Mustafa Smati Mohamed Jamali Alexandre Klein Michel Delahousse Séverine Martin Eric Thervet Xavier Belenfant Pablo Urena Carlos Vela Dominique Chauveau Viktor Panescu François Glowacki Maxime Hoffmann Maryvonne Hourmant Dominique Besnier Angelo Testa Philippe Zaoui Charles Chazot Laurent Juillard Stéphane Burtey Adrien Keller Nassim Kamar
author2Str	Jean Ferrières Eric Bruckert Céline Lange Sophie Liabeuf Maja Velkovski-Rouyer Bénédicte Stengel Carole Ayav Christian Combe Denis Fouque Luc Frimat Yves-Edouard Herpe Maurice Laville Ziad Massy Karine Legrand Marie Metzger Elodie Speyer Bruno Moulin Gaétan Lebrun Éric Magnant Gabriel Choukroun Jean Philippe Bourdenx Marie Essig Raymond Azar Mustafa Smati Mohamed Jamali Alexandre Klein Michel Delahousse Séverine Martin Eric Thervet Xavier Belenfant Pablo Urena Carlos Vela Dominique Chauveau Viktor Panescu François Glowacki Maxime Hoffmann Maryvonne Hourmant Dominique Besnier Angelo Testa Philippe Zaoui Charles Chazot Laurent Juillard Stéphane Burtey Adrien Keller Nassim Kamar
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