The Liquid Biopsy for Lung Cancer: State of the Art, Limitations and Future Developments

Lung cancer is a leading cause of cancer-related deaths, contributing to 18.4% of cancer deaths globally. Treatment of non-small cell lung carcinoma has seen rapid progression with targeted therapies tailored to specific genetic drivers. However, identifying genetic alterations can be difficult due...
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Autor*in:	Daniel Di Capua [verfasserIn] Dara Bracken-Clarke [verfasserIn] Karine Ronan [verfasserIn] Anne-Marie Baird [verfasserIn] Stephen Finn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	lung cancer liquid biopsy circulating tumor DNA circulating tumor cells non-small cell lung carcinoma

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 16, p 3923
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:16, p 3923

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13163923

Katalog-ID:	DOAJ049370693

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authorswithroles_txt_mv	Daniel Di Capua @@aut@@ Dara Bracken-Clarke @@aut@@ Karine Ronan @@aut@@ Anne-Marie Baird @@aut@@ Stephen Finn @@aut@@
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callnumber-first	R - Medicine
author	Daniel Di Capua
spellingShingle	Daniel Di Capua misc RC254-282 misc lung cancer misc liquid biopsy misc circulating tumor DNA misc circulating tumor cells misc non-small cell lung carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Liquid Biopsy for Lung Cancer: State of the Art, Limitations and Future Developments
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topic_title	RC254-282 The Liquid Biopsy for Lung Cancer: State of the Art, Limitations and Future Developments lung cancer liquid biopsy circulating tumor DNA circulating tumor cells non-small cell lung carcinoma
topic	misc RC254-282 misc lung cancer misc liquid biopsy misc circulating tumor DNA misc circulating tumor cells misc non-small cell lung carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc lung cancer misc liquid biopsy misc circulating tumor DNA misc circulating tumor cells misc non-small cell lung carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	liquid biopsy for lung cancer: state of the art, limitations and future developments
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title_auth	The Liquid Biopsy for Lung Cancer: State of the Art, Limitations and Future Developments
abstract	Lung cancer is a leading cause of cancer-related deaths, contributing to 18.4% of cancer deaths globally. Treatment of non-small cell lung carcinoma has seen rapid progression with targeted therapies tailored to specific genetic drivers. However, identifying genetic alterations can be difficult due to lack of tissue, inaccessible tumors and the risk of complications for the patient with serial tissue sampling. The liquid biopsy provides a minimally invasive method which can obtain circulating biomarkers shed from the tumor and could be a safer alternative to tissue biopsy. While tissue biopsy remains the gold standard, liquid biopsies could be very beneficial where serial sampling is required, such as monitoring disease progression or development of resistance mutations to current targeted therapies. Liquid biopsies also have a potential role in identifying patients at risk of relapse post treatment and as a component of future lung cancer screening protocols. Rapid developments have led to multiple platforms for isolating circulating tumor cells (CTCs) and detecting circulating tumor DNA (ctDNA); however, standardization is lacking, especially in lung carcinoma. Additionally, clonal hematopoiesis of uncertain clinical significance must be taken into consideration in genetic sequencing, as it introduces the potential for false positives. Various biomarkers have been investigated in liquid biopsies; however, in this review, we will concentrate on the current use of ctDNA and CTCs, focusing on the clinical relevance, current and possible future applications and limitations of each.
abstractGer	Lung cancer is a leading cause of cancer-related deaths, contributing to 18.4% of cancer deaths globally. Treatment of non-small cell lung carcinoma has seen rapid progression with targeted therapies tailored to specific genetic drivers. However, identifying genetic alterations can be difficult due to lack of tissue, inaccessible tumors and the risk of complications for the patient with serial tissue sampling. The liquid biopsy provides a minimally invasive method which can obtain circulating biomarkers shed from the tumor and could be a safer alternative to tissue biopsy. While tissue biopsy remains the gold standard, liquid biopsies could be very beneficial where serial sampling is required, such as monitoring disease progression or development of resistance mutations to current targeted therapies. Liquid biopsies also have a potential role in identifying patients at risk of relapse post treatment and as a component of future lung cancer screening protocols. Rapid developments have led to multiple platforms for isolating circulating tumor cells (CTCs) and detecting circulating tumor DNA (ctDNA); however, standardization is lacking, especially in lung carcinoma. Additionally, clonal hematopoiesis of uncertain clinical significance must be taken into consideration in genetic sequencing, as it introduces the potential for false positives. Various biomarkers have been investigated in liquid biopsies; however, in this review, we will concentrate on the current use of ctDNA and CTCs, focusing on the clinical relevance, current and possible future applications and limitations of each.
abstract_unstemmed	Lung cancer is a leading cause of cancer-related deaths, contributing to 18.4% of cancer deaths globally. Treatment of non-small cell lung carcinoma has seen rapid progression with targeted therapies tailored to specific genetic drivers. However, identifying genetic alterations can be difficult due to lack of tissue, inaccessible tumors and the risk of complications for the patient with serial tissue sampling. The liquid biopsy provides a minimally invasive method which can obtain circulating biomarkers shed from the tumor and could be a safer alternative to tissue biopsy. While tissue biopsy remains the gold standard, liquid biopsies could be very beneficial where serial sampling is required, such as monitoring disease progression or development of resistance mutations to current targeted therapies. Liquid biopsies also have a potential role in identifying patients at risk of relapse post treatment and as a component of future lung cancer screening protocols. Rapid developments have led to multiple platforms for isolating circulating tumor cells (CTCs) and detecting circulating tumor DNA (ctDNA); however, standardization is lacking, especially in lung carcinoma. Additionally, clonal hematopoiesis of uncertain clinical significance must be taken into consideration in genetic sequencing, as it introduces the potential for false positives. Various biomarkers have been investigated in liquid biopsies; however, in this review, we will concentrate on the current use of ctDNA and CTCs, focusing on the clinical relevance, current and possible future applications and limitations of each.
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