β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome

Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-rel...
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Autor*in:	Yik C. Ho [verfasserIn] Kiran D. K. Ahuja [verfasserIn] Heinrich Körner [verfasserIn] Murray J. Adams [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus

Übergeordnetes Werk:	In: Antibodies - MDPI AG, 2012, 5(2016), 2, p 12
Übergeordnetes Werk:	volume:5 ; year:2016 ; number:2, p 12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antib5020012

Katalog-ID:	DOAJ049371347

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Indexfelder

author_variant	y c h ych k d k a kdka h k hk m j a mja
matchkey_str	article:20734468:2016----::g1nig1nioisnpaeesepaesnhatp
hierarchy_sort_str	2016
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publishDate	2016
allfields	10.3390/antib5020012 doi (DE-627)DOAJ049371347 (DE-599)DOAJ6368e08bbf444e23a569a8a9cb8402a8 DE-627 ger DE-627 rakwb eng RC581-607 Yik C. Ho verfasserin aut β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways. anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy Kiran D. K. Ahuja verfasserin aut Heinrich Körner verfasserin aut Murray J. Adams verfasserin aut In Antibodies MDPI AG, 2012 5(2016), 2, p 12 (DE-627)718622065 (DE-600)2661514-9 20734468 nnns volume:5 year:2016 number:2, p 12 https://doi.org/10.3390/antib5020012 kostenfrei https://doaj.org/article/6368e08bbf444e23a569a8a9cb8402a8 kostenfrei http://www.mdpi.com/2073-4468/5/2/12 kostenfrei https://doaj.org/toc/2073-4468 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016 2, p 12
spelling	10.3390/antib5020012 doi (DE-627)DOAJ049371347 (DE-599)DOAJ6368e08bbf444e23a569a8a9cb8402a8 DE-627 ger DE-627 rakwb eng RC581-607 Yik C. Ho verfasserin aut β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways. anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy Kiran D. K. Ahuja verfasserin aut Heinrich Körner verfasserin aut Murray J. Adams verfasserin aut In Antibodies MDPI AG, 2012 5(2016), 2, p 12 (DE-627)718622065 (DE-600)2661514-9 20734468 nnns volume:5 year:2016 number:2, p 12 https://doi.org/10.3390/antib5020012 kostenfrei https://doaj.org/article/6368e08bbf444e23a569a8a9cb8402a8 kostenfrei http://www.mdpi.com/2073-4468/5/2/12 kostenfrei https://doaj.org/toc/2073-4468 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016 2, p 12
allfields_unstemmed	10.3390/antib5020012 doi (DE-627)DOAJ049371347 (DE-599)DOAJ6368e08bbf444e23a569a8a9cb8402a8 DE-627 ger DE-627 rakwb eng RC581-607 Yik C. Ho verfasserin aut β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways. anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy Kiran D. K. Ahuja verfasserin aut Heinrich Körner verfasserin aut Murray J. Adams verfasserin aut In Antibodies MDPI AG, 2012 5(2016), 2, p 12 (DE-627)718622065 (DE-600)2661514-9 20734468 nnns volume:5 year:2016 number:2, p 12 https://doi.org/10.3390/antib5020012 kostenfrei https://doaj.org/article/6368e08bbf444e23a569a8a9cb8402a8 kostenfrei http://www.mdpi.com/2073-4468/5/2/12 kostenfrei https://doaj.org/toc/2073-4468 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016 2, p 12
allfieldsGer	10.3390/antib5020012 doi (DE-627)DOAJ049371347 (DE-599)DOAJ6368e08bbf444e23a569a8a9cb8402a8 DE-627 ger DE-627 rakwb eng RC581-607 Yik C. Ho verfasserin aut β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways. anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy Kiran D. K. Ahuja verfasserin aut Heinrich Körner verfasserin aut Murray J. Adams verfasserin aut In Antibodies MDPI AG, 2012 5(2016), 2, p 12 (DE-627)718622065 (DE-600)2661514-9 20734468 nnns volume:5 year:2016 number:2, p 12 https://doi.org/10.3390/antib5020012 kostenfrei https://doaj.org/article/6368e08bbf444e23a569a8a9cb8402a8 kostenfrei http://www.mdpi.com/2073-4468/5/2/12 kostenfrei https://doaj.org/toc/2073-4468 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016 2, p 12
allfieldsSound	10.3390/antib5020012 doi (DE-627)DOAJ049371347 (DE-599)DOAJ6368e08bbf444e23a569a8a9cb8402a8 DE-627 ger DE-627 rakwb eng RC581-607 Yik C. Ho verfasserin aut β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways. anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy Kiran D. K. Ahuja verfasserin aut Heinrich Körner verfasserin aut Murray J. Adams verfasserin aut In Antibodies MDPI AG, 2012 5(2016), 2, p 12 (DE-627)718622065 (DE-600)2661514-9 20734468 nnns volume:5 year:2016 number:2, p 12 https://doi.org/10.3390/antib5020012 kostenfrei https://doaj.org/article/6368e08bbf444e23a569a8a9cb8402a8 kostenfrei http://www.mdpi.com/2073-4468/5/2/12 kostenfrei https://doaj.org/toc/2073-4468 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016 2, p 12
language	English
source	In Antibodies 5(2016), 2, p 12 volume:5 year:2016 number:2, p 12
sourceStr	In Antibodies 5(2016), 2, p 12 volume:5 year:2016 number:2, p 12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Antibodies
authorswithroles_txt_mv	Yik C. Ho @@aut@@ Kiran D. K. Ahuja @@aut@@ Heinrich Körner @@aut@@ Murray J. Adams @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	718622065
id	DOAJ049371347
language_de	englisch
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callnumber-first	R - Medicine
author	Yik C. Ho
spellingShingle	Yik C. Ho misc RC581-607 misc anti-beta 2 glycoprotein 1 antibodies misc beta 2 glycoprotein 1 misc platelet misc antiphospholipid antibody misc antiphospholipid syndrome misc systemic lupus erythematosus misc Immunologic diseases. Allergy β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
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topic_title	RC581-607 β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome anti-beta 2 glycoprotein 1 antibodies beta 2 glycoprotein 1 platelet antiphospholipid antibody antiphospholipid syndrome systemic lupus erythematosus
topic	misc RC581-607 misc anti-beta 2 glycoprotein 1 antibodies misc beta 2 glycoprotein 1 misc platelet misc antiphospholipid antibody misc antiphospholipid syndrome misc systemic lupus erythematosus misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc anti-beta 2 glycoprotein 1 antibodies misc beta 2 glycoprotein 1 misc platelet misc antiphospholipid antibody misc antiphospholipid syndrome misc systemic lupus erythematosus misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc anti-beta 2 glycoprotein 1 antibodies misc beta 2 glycoprotein 1 misc platelet misc antiphospholipid antibody misc antiphospholipid syndrome misc systemic lupus erythematosus misc Immunologic diseases. Allergy
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title	β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
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title_full	β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
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author_browse	Yik C. Ho Kiran D. K. Ahuja Heinrich Körner Murray J. Adams
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title_sort	β2gp1, anti-β2gp1 antibodies and platelets: key players in the antiphospholipid syndrome
callnumber	RC581-607
title_auth	β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
abstract	Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways.
abstractGer	Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways.
abstract_unstemmed	Anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are commonly found in patients with autoimmune diseases such as the antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Their presence is highly associated with increased risk of vascular thrombosis and/or recurrent pregnancy-related complications. Although they are a subtype of anti-phospholipid (APL) antibody, anti-β2GP1 antibodies form complexes with β2GP1 before binding to different receptors associated with anionic phospholipids on structures such as platelets and endothelial cells. β2GP1 consists of five short consensus repeat termed “sushi” domains. It has three interchangeable conformations with a cryptic epitope at domain 1 within the molecule. Anti-β2GP1 antibodies against this cryptic epitope are referred to as ‘type A’ antibodies, and have been suggested to be more strongly associated with both vascular and obstetric complications. In contrast, ‘type B’ antibodies, directed against other domains of β2GP1, are more likely to be benign antibodies found in asymptomatic patients and healthy individuals. Although the interactions between anti-β2GP1 antibodies, β2GP1, and platelets have been investigated, the actual targeted metabolic pathway(s) and/or receptor(s) involved remain to be clearly elucidated. This review will discuss the current understanding of the interaction between anti-β2GP1 antibodies and β2GP1, with platelet receptors and associated signalling pathways.
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container_issue	2, p 12
title_short	β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
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