Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study

Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW...
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Gespeichert in:

Autor*in:	Longjian Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	CVD Risk CKD quantile regression

Übergeordnetes Werk:	In: International Cardiovascular Forum Journal - Barcaray International, 2017, 2(2015), 1, Seite 20-26
Übergeordnetes Werk:	volume:2 ; year:2015 ; number:1 ; pages:20-26

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ049403796

Internformat


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245	1	0	\|a Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
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520			\|a Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW.
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allfields	(DE-627)DOAJ049403796 (DE-599)DOAJf3cf81a000fe497db513d71334252621 DE-627 ger DE-627 rakwb eng RC666-701 Longjian Liu verfasserin aut Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. CVD Risk CKD quantile regression Medicine R Diseases of the circulatory (Cardiovascular) system In International Cardiovascular Forum Journal Barcaray International, 2017 2(2015), 1, Seite 20-26 (DE-627)859466345 (DE-600)2855971-X 24093424 nnns volume:2 year:2015 number:1 pages:20-26 https://doi.org/10.17987/icfj.v2i1.70 kostenfrei https://doaj.org/article/f3cf81a000fe497db513d71334252621 kostenfrei http://icfjournal.org/index.php/icfj/article/view/70/89 kostenfrei https://doaj.org/toc/2410-2636 Journal toc kostenfrei https://doaj.org/toc/2409-3424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2015 1 20-26
spelling	(DE-627)DOAJ049403796 (DE-599)DOAJf3cf81a000fe497db513d71334252621 DE-627 ger DE-627 rakwb eng RC666-701 Longjian Liu verfasserin aut Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. CVD Risk CKD quantile regression Medicine R Diseases of the circulatory (Cardiovascular) system In International Cardiovascular Forum Journal Barcaray International, 2017 2(2015), 1, Seite 20-26 (DE-627)859466345 (DE-600)2855971-X 24093424 nnns volume:2 year:2015 number:1 pages:20-26 https://doi.org/10.17987/icfj.v2i1.70 kostenfrei https://doaj.org/article/f3cf81a000fe497db513d71334252621 kostenfrei http://icfjournal.org/index.php/icfj/article/view/70/89 kostenfrei https://doaj.org/toc/2410-2636 Journal toc kostenfrei https://doaj.org/toc/2409-3424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2015 1 20-26
allfields_unstemmed	(DE-627)DOAJ049403796 (DE-599)DOAJf3cf81a000fe497db513d71334252621 DE-627 ger DE-627 rakwb eng RC666-701 Longjian Liu verfasserin aut Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. CVD Risk CKD quantile regression Medicine R Diseases of the circulatory (Cardiovascular) system In International Cardiovascular Forum Journal Barcaray International, 2017 2(2015), 1, Seite 20-26 (DE-627)859466345 (DE-600)2855971-X 24093424 nnns volume:2 year:2015 number:1 pages:20-26 https://doi.org/10.17987/icfj.v2i1.70 kostenfrei https://doaj.org/article/f3cf81a000fe497db513d71334252621 kostenfrei http://icfjournal.org/index.php/icfj/article/view/70/89 kostenfrei https://doaj.org/toc/2410-2636 Journal toc kostenfrei https://doaj.org/toc/2409-3424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2015 1 20-26
allfieldsGer	(DE-627)DOAJ049403796 (DE-599)DOAJf3cf81a000fe497db513d71334252621 DE-627 ger DE-627 rakwb eng RC666-701 Longjian Liu verfasserin aut Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. CVD Risk CKD quantile regression Medicine R Diseases of the circulatory (Cardiovascular) system In International Cardiovascular Forum Journal Barcaray International, 2017 2(2015), 1, Seite 20-26 (DE-627)859466345 (DE-600)2855971-X 24093424 nnns volume:2 year:2015 number:1 pages:20-26 https://doi.org/10.17987/icfj.v2i1.70 kostenfrei https://doaj.org/article/f3cf81a000fe497db513d71334252621 kostenfrei http://icfjournal.org/index.php/icfj/article/view/70/89 kostenfrei https://doaj.org/toc/2410-2636 Journal toc kostenfrei https://doaj.org/toc/2409-3424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2015 1 20-26
allfieldsSound	(DE-627)DOAJ049403796 (DE-599)DOAJf3cf81a000fe497db513d71334252621 DE-627 ger DE-627 rakwb eng RC666-701 Longjian Liu verfasserin aut Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW. CVD Risk CKD quantile regression Medicine R Diseases of the circulatory (Cardiovascular) system In International Cardiovascular Forum Journal Barcaray International, 2017 2(2015), 1, Seite 20-26 (DE-627)859466345 (DE-600)2855971-X 24093424 nnns volume:2 year:2015 number:1 pages:20-26 https://doi.org/10.17987/icfj.v2i1.70 kostenfrei https://doaj.org/article/f3cf81a000fe497db513d71334252621 kostenfrei http://icfjournal.org/index.php/icfj/article/view/70/89 kostenfrei https://doaj.org/toc/2410-2636 Journal toc kostenfrei https://doaj.org/toc/2409-3424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2015 1 20-26
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callnumber-first	R - Medicine
author	Longjian Liu
spellingShingle	Longjian Liu misc RC666-701 misc CVD Risk misc CKD misc quantile regression misc Medicine misc R misc Diseases of the circulatory (Cardiovascular) system Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
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topic_title	RC666-701 Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study CVD Risk CKD quantile regression
topic	misc RC666-701 misc CVD Risk misc CKD misc quantile regression misc Medicine misc R misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc CVD Risk misc CKD misc quantile regression misc Medicine misc R misc Diseases of the circulatory (Cardiovascular) system
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title	Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
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title_full	Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
author_sort	Longjian Liu
journal	International Cardiovascular Forum Journal
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author-letter	Longjian Liu
title_sort	using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: findings from the u.s. chronic renal insufficiency cohort study
callnumber	RC666-701
title_auth	Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
abstract	Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW.
abstractGer	Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW.
abstract_unstemmed	Background and Aims: Adults with chronic kidney disease (CKD) carry an extraordinarily high risk for cardiovascular disease (CVD). The present study aimed to test two hypotheses that: (1) CVD risk factors disproportionately affect non-Hispanic black (NHB) with CKD compared to non-Hispanic white (NHW). (2) This difference significantly contributes to an excess risk of CVD in NHB versus NHW. Methods: A total of 3,939 aged 21-74 years old participating in the Chronic Renal Insufficiency Cohort Study was analyzed. A sum weighted CVDRisk score was constructed from well-established CVD risk factors. Differences in CVD Risk score by race/ethnicity were tested using quantile regression (Qreg) analysis. Results: The prevalence of CVD was 30.7% in NHW and 38.2% in NHB (p<0.001). The means (SD) of CVD Risk score were 12.6 (5.7) in NHW and 14.6 (6.4) in NHB (p<0.001). Qreg analysis indicated that NHB with estimate glomerular filtration rate (eGFR) 30-59.9 ml/min/1.73m2 had significantly higher (worse) CVD Risk scores across all quantiles (Qs) than NHW. This race differences in CVD Risk were also significantly higher in NHB with eGFR 60-70 ml/min/1.73m2 in Qs 1 and 2 as compared to their NHW counterparts. An estimated 35.8% of the excess prevalent CVD could be attributable to the difference in CVD Risk for NHB versus NHW. Conclusion: NHB have a significantly higher CVD risk factor score in those with moderate and mild CKD than NHW.
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title_short	Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study
url	https://doi.org/10.17987/icfj.v2i1.70 https://doaj.org/article/f3cf81a000fe497db513d71334252621 http://icfjournal.org/index.php/icfj/article/view/70/89 https://doaj.org/toc/2410-2636 https://doaj.org/toc/2409-3424
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Using multivariate quantile regression analysis to explore cardiovascular risk differences in subjects with chronic kidney disease by race and ethnicity: Findings from the U.S. Chronic Renal Insufficiency Cohort Study

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