A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching
Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entir...
Ausführliche Beschreibung
Autor*in: |
Fang Luo [verfasserIn] Wenbin Yang [verfasserIn] Mingbo Yin [verfasserIn] Xiaojin Mo [verfasserIn] Yuhong Pang [verfasserIn] Chengsong Sun [verfasserIn] Bingkuan Zhu [verfasserIn] Wei Zhang [verfasserIn] Cun Yi [verfasserIn] Zhidan Li [verfasserIn] Jipeng Wang [verfasserIn] Bin Xu [verfasserIn] Zheng Feng [verfasserIn] Yangyi Huang [verfasserIn] Yan Lu [verfasserIn] Wei Hu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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In: Cell Reports - Elsevier, 2015, 39(2022), 1, Seite 110638- |
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volume:39 ; year:2022 ; number:1 ; pages:110638- |
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DOI / URN: |
10.1016/j.celrep.2022.110638 |
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Katalog-ID: |
DOAJ049484966 |
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245 | 1 | 2 | |a A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
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520 | |a Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. | ||
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10.1016/j.celrep.2022.110638 doi (DE-627)DOAJ049484966 (DE-599)DOAJf8bb7f236b4d42fca7d407870a122584 DE-627 ger DE-627 rakwb eng QH301-705.5 Fang Luo verfasserin aut A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. CP: Microbiology Biology (General) Wenbin Yang verfasserin aut Mingbo Yin verfasserin aut Xiaojin Mo verfasserin aut Yuhong Pang verfasserin aut Chengsong Sun verfasserin aut Bingkuan Zhu verfasserin aut Wei Zhang verfasserin aut Cun Yi verfasserin aut Zhidan Li verfasserin aut Jipeng Wang verfasserin aut Bin Xu verfasserin aut Zheng Feng verfasserin aut Yangyi Huang verfasserin aut Yan Lu verfasserin aut Wei Hu verfasserin aut In Cell Reports Elsevier, 2015 39(2022), 1, Seite 110638- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:39 year:2022 number:1 pages:110638- https://doi.org/10.1016/j.celrep.2022.110638 kostenfrei https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124722003904 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 39 2022 1 110638- |
spelling |
10.1016/j.celrep.2022.110638 doi (DE-627)DOAJ049484966 (DE-599)DOAJf8bb7f236b4d42fca7d407870a122584 DE-627 ger DE-627 rakwb eng QH301-705.5 Fang Luo verfasserin aut A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. CP: Microbiology Biology (General) Wenbin Yang verfasserin aut Mingbo Yin verfasserin aut Xiaojin Mo verfasserin aut Yuhong Pang verfasserin aut Chengsong Sun verfasserin aut Bingkuan Zhu verfasserin aut Wei Zhang verfasserin aut Cun Yi verfasserin aut Zhidan Li verfasserin aut Jipeng Wang verfasserin aut Bin Xu verfasserin aut Zheng Feng verfasserin aut Yangyi Huang verfasserin aut Yan Lu verfasserin aut Wei Hu verfasserin aut In Cell Reports Elsevier, 2015 39(2022), 1, Seite 110638- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:39 year:2022 number:1 pages:110638- https://doi.org/10.1016/j.celrep.2022.110638 kostenfrei https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124722003904 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 39 2022 1 110638- |
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10.1016/j.celrep.2022.110638 doi (DE-627)DOAJ049484966 (DE-599)DOAJf8bb7f236b4d42fca7d407870a122584 DE-627 ger DE-627 rakwb eng QH301-705.5 Fang Luo verfasserin aut A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. CP: Microbiology Biology (General) Wenbin Yang verfasserin aut Mingbo Yin verfasserin aut Xiaojin Mo verfasserin aut Yuhong Pang verfasserin aut Chengsong Sun verfasserin aut Bingkuan Zhu verfasserin aut Wei Zhang verfasserin aut Cun Yi verfasserin aut Zhidan Li verfasserin aut Jipeng Wang verfasserin aut Bin Xu verfasserin aut Zheng Feng verfasserin aut Yangyi Huang verfasserin aut Yan Lu verfasserin aut Wei Hu verfasserin aut In Cell Reports Elsevier, 2015 39(2022), 1, Seite 110638- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:39 year:2022 number:1 pages:110638- https://doi.org/10.1016/j.celrep.2022.110638 kostenfrei https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124722003904 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 39 2022 1 110638- |
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10.1016/j.celrep.2022.110638 doi (DE-627)DOAJ049484966 (DE-599)DOAJf8bb7f236b4d42fca7d407870a122584 DE-627 ger DE-627 rakwb eng QH301-705.5 Fang Luo verfasserin aut A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. CP: Microbiology Biology (General) Wenbin Yang verfasserin aut Mingbo Yin verfasserin aut Xiaojin Mo verfasserin aut Yuhong Pang verfasserin aut Chengsong Sun verfasserin aut Bingkuan Zhu verfasserin aut Wei Zhang verfasserin aut Cun Yi verfasserin aut Zhidan Li verfasserin aut Jipeng Wang verfasserin aut Bin Xu verfasserin aut Zheng Feng verfasserin aut Yangyi Huang verfasserin aut Yan Lu verfasserin aut Wei Hu verfasserin aut In Cell Reports Elsevier, 2015 39(2022), 1, Seite 110638- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:39 year:2022 number:1 pages:110638- https://doi.org/10.1016/j.celrep.2022.110638 kostenfrei https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124722003904 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 39 2022 1 110638- |
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10.1016/j.celrep.2022.110638 doi (DE-627)DOAJ049484966 (DE-599)DOAJf8bb7f236b4d42fca7d407870a122584 DE-627 ger DE-627 rakwb eng QH301-705.5 Fang Luo verfasserin aut A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. CP: Microbiology Biology (General) Wenbin Yang verfasserin aut Mingbo Yin verfasserin aut Xiaojin Mo verfasserin aut Yuhong Pang verfasserin aut Chengsong Sun verfasserin aut Bingkuan Zhu verfasserin aut Wei Zhang verfasserin aut Cun Yi verfasserin aut Zhidan Li verfasserin aut Jipeng Wang verfasserin aut Bin Xu verfasserin aut Zheng Feng verfasserin aut Yangyi Huang verfasserin aut Yan Lu verfasserin aut Wei Hu verfasserin aut In Cell Reports Elsevier, 2015 39(2022), 1, Seite 110638- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:39 year:2022 number:1 pages:110638- https://doi.org/10.1016/j.celrep.2022.110638 kostenfrei https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124722003904 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 39 2022 1 110638- |
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Fang Luo @@aut@@ Wenbin Yang @@aut@@ Mingbo Yin @@aut@@ Xiaojin Mo @@aut@@ Yuhong Pang @@aut@@ Chengsong Sun @@aut@@ Bingkuan Zhu @@aut@@ Wei Zhang @@aut@@ Cun Yi @@aut@@ Zhidan Li @@aut@@ Jipeng Wang @@aut@@ Bin Xu @@aut@@ Zheng Feng @@aut@@ Yangyi Huang @@aut@@ Yan Lu @@aut@@ Wei Hu @@aut@@ |
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Fang Luo Wenbin Yang Mingbo Yin Xiaojin Mo Yuhong Pang Chengsong Sun Bingkuan Zhu Wei Zhang Cun Yi Zhidan Li Jipeng Wang Bin Xu Zheng Feng Yangyi Huang Yan Lu Wei Hu |
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chromosome-level genome of the human blood fluke schistosoma japonicum identifies the genomic basis of host-switching |
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A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
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Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. |
abstractGer |
Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. |
abstract_unstemmed |
Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. |
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A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
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https://doi.org/10.1016/j.celrep.2022.110638 https://doaj.org/article/f8bb7f236b4d42fca7d407870a122584 http://www.sciencedirect.com/science/article/pii/S2211124722003904 https://doaj.org/toc/2211-1247 |
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