Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study

Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Alessio Cortellini [verfasserIn] Andrea De Giglio [verfasserIn] Katia Cannita [verfasserIn] Diego L. Cortinovis [verfasserIn] Robin Cornelissen [verfasserIn] Cinzia Baldessari [verfasserIn] Raffaele Giusti [verfasserIn] Ettore D'Argento [verfasserIn] Francesco Grossi [verfasserIn] Matteo Santoni [verfasserIn] Annamaria Catino [verfasserIn] Rossana Berardi [verfasserIn] Vincenzo Sforza [verfasserIn] Giovanni Rossi [verfasserIn] Lorenzo Antonuzzo [verfasserIn] Vincenzo Di Noia [verfasserIn] Diego Signorelli [verfasserIn] Alain Gelibter [verfasserIn] Mario Alberto Occhipinti [verfasserIn] Alessandro Follador [verfasserIn] Francesca Rastelli [verfasserIn] Rita Chiari [verfasserIn] Luigi Della Gravara [verfasserIn] Alessandro Inno [verfasserIn] Michele De Tursi [verfasserIn] Pietro Di Marino [verfasserIn] Giovanni Mansueto [verfasserIn] Federica Zoratto [verfasserIn] Marco Filetti [verfasserIn] Michele Montrone [verfasserIn] Fabrizio Citarella [verfasserIn] Maria Vittoria Pensieri [verfasserIn] Marco Russano [verfasserIn] Luca Cantini [verfasserIn] Olga Nigro [verfasserIn] Alessandro Leonetti [verfasserIn] Paola Bordi [verfasserIn] Gabriele Minuti [verfasserIn] Lorenza Landi [verfasserIn] Alessandro De Toma [verfasserIn] Clelia Donisi [verfasserIn] Serena Ricciardi [verfasserIn] Maria Rita Migliorino [verfasserIn] Valerio Maria Napoli [verfasserIn] Gianmarco Leone [verfasserIn] Giulio Metro [verfasserIn] Giuseppe L. Banna [verfasserIn] Alex Friedlaender [verfasserIn] Alfredo Addeo [verfasserIn] Corrado Ficorella [verfasserIn] Giampiero Porzio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco

Übergeordnetes Werk:	In: Thoracic Cancer - Wiley, 2015, 12(2021), 6, Seite 880-889
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:6 ; pages:880-889

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1111/1759-7714.13852

Katalog-ID:	DOAJ04962752X

Internformat


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100	0		\|a Alessio Cortellini \|e verfasserin \|4 aut
245	1	0	\|a Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
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520			\|a Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy.
650		4	\|a immunotherapy
650		4	\|a non‐small cell lung cancer
650		4	\|a pembrolizumab
650		4	\|a smoking
650		4	\|a tobacco
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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700	0		\|a Katia Cannita \|e verfasserin \|4 aut
700	0		\|a Diego L. Cortinovis \|e verfasserin \|4 aut
700	0		\|a Robin Cornelissen \|e verfasserin \|4 aut
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700	0		\|a Matteo Santoni \|e verfasserin \|4 aut
700	0		\|a Annamaria Catino \|e verfasserin \|4 aut
700	0		\|a Rossana Berardi \|e verfasserin \|4 aut
700	0		\|a Vincenzo Sforza \|e verfasserin \|4 aut
700	0		\|a Giovanni Rossi \|e verfasserin \|4 aut
700	0		\|a Lorenzo Antonuzzo \|e verfasserin \|4 aut
700	0		\|a Vincenzo Di Noia \|e verfasserin \|4 aut
700	0		\|a Diego Signorelli \|e verfasserin \|4 aut
700	0		\|a Alain Gelibter \|e verfasserin \|4 aut
700	0		\|a Mario Alberto Occhipinti \|e verfasserin \|4 aut
700	0		\|a Alessandro Follador \|e verfasserin \|4 aut
700	0		\|a Francesca Rastelli \|e verfasserin \|4 aut
700	0		\|a Rita Chiari \|e verfasserin \|4 aut
700	0		\|a Luigi Della Gravara \|e verfasserin \|4 aut
700	0		\|a Alessandro Inno \|e verfasserin \|4 aut
700	0		\|a Michele De Tursi \|e verfasserin \|4 aut
700	0		\|a Pietro Di Marino \|e verfasserin \|4 aut
700	0		\|a Giovanni Mansueto \|e verfasserin \|4 aut
700	0		\|a Federica Zoratto \|e verfasserin \|4 aut
700	0		\|a Marco Filetti \|e verfasserin \|4 aut
700	0		\|a Michele Montrone \|e verfasserin \|4 aut
700	0		\|a Fabrizio Citarella \|e verfasserin \|4 aut
700	0		\|a Maria Vittoria Pensieri \|e verfasserin \|4 aut
700	0		\|a Marco Russano \|e verfasserin \|4 aut
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700	0		\|a Alessandro Leonetti \|e verfasserin \|4 aut
700	0		\|a Paola Bordi \|e verfasserin \|4 aut
700	0		\|a Gabriele Minuti \|e verfasserin \|4 aut
700	0		\|a Lorenza Landi \|e verfasserin \|4 aut
700	0		\|a Alessandro De Toma \|e verfasserin \|4 aut
700	0		\|a Clelia Donisi \|e verfasserin \|4 aut
700	0		\|a Serena Ricciardi \|e verfasserin \|4 aut
700	0		\|a Maria Rita Migliorino \|e verfasserin \|4 aut
700	0		\|a Valerio Maria Napoli \|e verfasserin \|4 aut
700	0		\|a Gianmarco Leone \|e verfasserin \|4 aut
700	0		\|a Giulio Metro \|e verfasserin \|4 aut
700	0		\|a Giuseppe L. Banna \|e verfasserin \|4 aut
700	0		\|a Alex Friedlaender \|e verfasserin \|4 aut
700	0		\|a Alfredo Addeo \|e verfasserin \|4 aut
700	0		\|a Corrado Ficorella \|e verfasserin \|4 aut
700	0		\|a Giampiero Porzio \|e verfasserin \|4 aut
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allfields	10.1111/1759-7714.13852 doi (DE-627)DOAJ04962752X (DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd DE-627 ger DE-627 rakwb eng RC254-282 Alessio Cortellini verfasserin aut Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andrea De Giglio verfasserin aut Katia Cannita verfasserin aut Diego L. Cortinovis verfasserin aut Robin Cornelissen verfasserin aut Cinzia Baldessari verfasserin aut Raffaele Giusti verfasserin aut Ettore D'Argento verfasserin aut Francesco Grossi verfasserin aut Matteo Santoni verfasserin aut Annamaria Catino verfasserin aut Rossana Berardi verfasserin aut Vincenzo Sforza verfasserin aut Giovanni Rossi verfasserin aut Lorenzo Antonuzzo verfasserin aut Vincenzo Di Noia verfasserin aut Diego Signorelli verfasserin aut Alain Gelibter verfasserin aut Mario Alberto Occhipinti verfasserin aut Alessandro Follador verfasserin aut Francesca Rastelli verfasserin aut Rita Chiari verfasserin aut Luigi Della Gravara verfasserin aut Alessandro Inno verfasserin aut Michele De Tursi verfasserin aut Pietro Di Marino verfasserin aut Giovanni Mansueto verfasserin aut Federica Zoratto verfasserin aut Marco Filetti verfasserin aut Michele Montrone verfasserin aut Fabrizio Citarella verfasserin aut Maria Vittoria Pensieri verfasserin aut Marco Russano verfasserin aut Luca Cantini verfasserin aut Olga Nigro verfasserin aut Alessandro Leonetti verfasserin aut Paola Bordi verfasserin aut Gabriele Minuti verfasserin aut Lorenza Landi verfasserin aut Alessandro De Toma verfasserin aut Clelia Donisi verfasserin aut Serena Ricciardi verfasserin aut Maria Rita Migliorino verfasserin aut Valerio Maria Napoli verfasserin aut Gianmarco Leone verfasserin aut Giulio Metro verfasserin aut Giuseppe L. Banna verfasserin aut Alex Friedlaender verfasserin aut Alfredo Addeo verfasserin aut Corrado Ficorella verfasserin aut Giampiero Porzio verfasserin aut In Thoracic Cancer Wiley, 2015 12(2021), 6, Seite 880-889 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:12 year:2021 number:6 pages:880-889 https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd kostenfrei https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 880-889
spelling	10.1111/1759-7714.13852 doi (DE-627)DOAJ04962752X (DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd DE-627 ger DE-627 rakwb eng RC254-282 Alessio Cortellini verfasserin aut Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andrea De Giglio verfasserin aut Katia Cannita verfasserin aut Diego L. Cortinovis verfasserin aut Robin Cornelissen verfasserin aut Cinzia Baldessari verfasserin aut Raffaele Giusti verfasserin aut Ettore D'Argento verfasserin aut Francesco Grossi verfasserin aut Matteo Santoni verfasserin aut Annamaria Catino verfasserin aut Rossana Berardi verfasserin aut Vincenzo Sforza verfasserin aut Giovanni Rossi verfasserin aut Lorenzo Antonuzzo verfasserin aut Vincenzo Di Noia verfasserin aut Diego Signorelli verfasserin aut Alain Gelibter verfasserin aut Mario Alberto Occhipinti verfasserin aut Alessandro Follador verfasserin aut Francesca Rastelli verfasserin aut Rita Chiari verfasserin aut Luigi Della Gravara verfasserin aut Alessandro Inno verfasserin aut Michele De Tursi verfasserin aut Pietro Di Marino verfasserin aut Giovanni Mansueto verfasserin aut Federica Zoratto verfasserin aut Marco Filetti verfasserin aut Michele Montrone verfasserin aut Fabrizio Citarella verfasserin aut Maria Vittoria Pensieri verfasserin aut Marco Russano verfasserin aut Luca Cantini verfasserin aut Olga Nigro verfasserin aut Alessandro Leonetti verfasserin aut Paola Bordi verfasserin aut Gabriele Minuti verfasserin aut Lorenza Landi verfasserin aut Alessandro De Toma verfasserin aut Clelia Donisi verfasserin aut Serena Ricciardi verfasserin aut Maria Rita Migliorino verfasserin aut Valerio Maria Napoli verfasserin aut Gianmarco Leone verfasserin aut Giulio Metro verfasserin aut Giuseppe L. Banna verfasserin aut Alex Friedlaender verfasserin aut Alfredo Addeo verfasserin aut Corrado Ficorella verfasserin aut Giampiero Porzio verfasserin aut In Thoracic Cancer Wiley, 2015 12(2021), 6, Seite 880-889 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:12 year:2021 number:6 pages:880-889 https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd kostenfrei https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 880-889
allfields_unstemmed	10.1111/1759-7714.13852 doi (DE-627)DOAJ04962752X (DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd DE-627 ger DE-627 rakwb eng RC254-282 Alessio Cortellini verfasserin aut Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andrea De Giglio verfasserin aut Katia Cannita verfasserin aut Diego L. Cortinovis verfasserin aut Robin Cornelissen verfasserin aut Cinzia Baldessari verfasserin aut Raffaele Giusti verfasserin aut Ettore D'Argento verfasserin aut Francesco Grossi verfasserin aut Matteo Santoni verfasserin aut Annamaria Catino verfasserin aut Rossana Berardi verfasserin aut Vincenzo Sforza verfasserin aut Giovanni Rossi verfasserin aut Lorenzo Antonuzzo verfasserin aut Vincenzo Di Noia verfasserin aut Diego Signorelli verfasserin aut Alain Gelibter verfasserin aut Mario Alberto Occhipinti verfasserin aut Alessandro Follador verfasserin aut Francesca Rastelli verfasserin aut Rita Chiari verfasserin aut Luigi Della Gravara verfasserin aut Alessandro Inno verfasserin aut Michele De Tursi verfasserin aut Pietro Di Marino verfasserin aut Giovanni Mansueto verfasserin aut Federica Zoratto verfasserin aut Marco Filetti verfasserin aut Michele Montrone verfasserin aut Fabrizio Citarella verfasserin aut Maria Vittoria Pensieri verfasserin aut Marco Russano verfasserin aut Luca Cantini verfasserin aut Olga Nigro verfasserin aut Alessandro Leonetti verfasserin aut Paola Bordi verfasserin aut Gabriele Minuti verfasserin aut Lorenza Landi verfasserin aut Alessandro De Toma verfasserin aut Clelia Donisi verfasserin aut Serena Ricciardi verfasserin aut Maria Rita Migliorino verfasserin aut Valerio Maria Napoli verfasserin aut Gianmarco Leone verfasserin aut Giulio Metro verfasserin aut Giuseppe L. Banna verfasserin aut Alex Friedlaender verfasserin aut Alfredo Addeo verfasserin aut Corrado Ficorella verfasserin aut Giampiero Porzio verfasserin aut In Thoracic Cancer Wiley, 2015 12(2021), 6, Seite 880-889 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:12 year:2021 number:6 pages:880-889 https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd kostenfrei https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 880-889
allfieldsGer	10.1111/1759-7714.13852 doi (DE-627)DOAJ04962752X (DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd DE-627 ger DE-627 rakwb eng RC254-282 Alessio Cortellini verfasserin aut Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andrea De Giglio verfasserin aut Katia Cannita verfasserin aut Diego L. Cortinovis verfasserin aut Robin Cornelissen verfasserin aut Cinzia Baldessari verfasserin aut Raffaele Giusti verfasserin aut Ettore D'Argento verfasserin aut Francesco Grossi verfasserin aut Matteo Santoni verfasserin aut Annamaria Catino verfasserin aut Rossana Berardi verfasserin aut Vincenzo Sforza verfasserin aut Giovanni Rossi verfasserin aut Lorenzo Antonuzzo verfasserin aut Vincenzo Di Noia verfasserin aut Diego Signorelli verfasserin aut Alain Gelibter verfasserin aut Mario Alberto Occhipinti verfasserin aut Alessandro Follador verfasserin aut Francesca Rastelli verfasserin aut Rita Chiari verfasserin aut Luigi Della Gravara verfasserin aut Alessandro Inno verfasserin aut Michele De Tursi verfasserin aut Pietro Di Marino verfasserin aut Giovanni Mansueto verfasserin aut Federica Zoratto verfasserin aut Marco Filetti verfasserin aut Michele Montrone verfasserin aut Fabrizio Citarella verfasserin aut Maria Vittoria Pensieri verfasserin aut Marco Russano verfasserin aut Luca Cantini verfasserin aut Olga Nigro verfasserin aut Alessandro Leonetti verfasserin aut Paola Bordi verfasserin aut Gabriele Minuti verfasserin aut Lorenza Landi verfasserin aut Alessandro De Toma verfasserin aut Clelia Donisi verfasserin aut Serena Ricciardi verfasserin aut Maria Rita Migliorino verfasserin aut Valerio Maria Napoli verfasserin aut Gianmarco Leone verfasserin aut Giulio Metro verfasserin aut Giuseppe L. Banna verfasserin aut Alex Friedlaender verfasserin aut Alfredo Addeo verfasserin aut Corrado Ficorella verfasserin aut Giampiero Porzio verfasserin aut In Thoracic Cancer Wiley, 2015 12(2021), 6, Seite 880-889 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:12 year:2021 number:6 pages:880-889 https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd kostenfrei https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 880-889
allfieldsSound	10.1111/1759-7714.13852 doi (DE-627)DOAJ04962752X (DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd DE-627 ger DE-627 rakwb eng RC254-282 Alessio Cortellini verfasserin aut Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy. immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andrea De Giglio verfasserin aut Katia Cannita verfasserin aut Diego L. Cortinovis verfasserin aut Robin Cornelissen verfasserin aut Cinzia Baldessari verfasserin aut Raffaele Giusti verfasserin aut Ettore D'Argento verfasserin aut Francesco Grossi verfasserin aut Matteo Santoni verfasserin aut Annamaria Catino verfasserin aut Rossana Berardi verfasserin aut Vincenzo Sforza verfasserin aut Giovanni Rossi verfasserin aut Lorenzo Antonuzzo verfasserin aut Vincenzo Di Noia verfasserin aut Diego Signorelli verfasserin aut Alain Gelibter verfasserin aut Mario Alberto Occhipinti verfasserin aut Alessandro Follador verfasserin aut Francesca Rastelli verfasserin aut Rita Chiari verfasserin aut Luigi Della Gravara verfasserin aut Alessandro Inno verfasserin aut Michele De Tursi verfasserin aut Pietro Di Marino verfasserin aut Giovanni Mansueto verfasserin aut Federica Zoratto verfasserin aut Marco Filetti verfasserin aut Michele Montrone verfasserin aut Fabrizio Citarella verfasserin aut Maria Vittoria Pensieri verfasserin aut Marco Russano verfasserin aut Luca Cantini verfasserin aut Olga Nigro verfasserin aut Alessandro Leonetti verfasserin aut Paola Bordi verfasserin aut Gabriele Minuti verfasserin aut Lorenza Landi verfasserin aut Alessandro De Toma verfasserin aut Clelia Donisi verfasserin aut Serena Ricciardi verfasserin aut Maria Rita Migliorino verfasserin aut Valerio Maria Napoli verfasserin aut Gianmarco Leone verfasserin aut Giulio Metro verfasserin aut Giuseppe L. Banna verfasserin aut Alex Friedlaender verfasserin aut Alfredo Addeo verfasserin aut Corrado Ficorella verfasserin aut Giampiero Porzio verfasserin aut In Thoracic Cancer Wiley, 2015 12(2021), 6, Seite 880-889 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:12 year:2021 number:6 pages:880-889 https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd kostenfrei https://doi.org/10.1111/1759-7714.13852 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 880-889
language	English
source	In Thoracic Cancer 12(2021), 6, Seite 880-889 volume:12 year:2021 number:6 pages:880-889
sourceStr	In Thoracic Cancer 12(2021), 6, Seite 880-889 volume:12 year:2021 number:6 pages:880-889
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Thoracic Cancer
authorswithroles_txt_mv	Alessio Cortellini @@aut@@ Andrea De Giglio @@aut@@ Katia Cannita @@aut@@ Diego L. Cortinovis @@aut@@ Robin Cornelissen @@aut@@ Cinzia Baldessari @@aut@@ Raffaele Giusti @@aut@@ Ettore D'Argento @@aut@@ Francesco Grossi @@aut@@ Matteo Santoni @@aut@@ Annamaria Catino @@aut@@ Rossana Berardi @@aut@@ Vincenzo Sforza @@aut@@ Giovanni Rossi @@aut@@ Lorenzo Antonuzzo @@aut@@ Vincenzo Di Noia @@aut@@ Diego Signorelli @@aut@@ Alain Gelibter @@aut@@ Mario Alberto Occhipinti @@aut@@ Alessandro Follador @@aut@@ Francesca Rastelli @@aut@@ Rita Chiari @@aut@@ Luigi Della Gravara @@aut@@ Alessandro Inno @@aut@@ Michele De Tursi @@aut@@ Pietro Di Marino @@aut@@ Giovanni Mansueto @@aut@@ Federica Zoratto @@aut@@ Marco Filetti @@aut@@ Michele Montrone @@aut@@ Fabrizio Citarella @@aut@@ Maria Vittoria Pensieri @@aut@@ Marco Russano @@aut@@ Luca Cantini @@aut@@ Olga Nigro @@aut@@ Alessandro Leonetti @@aut@@ Paola Bordi @@aut@@ Gabriele Minuti @@aut@@ Lorenza Landi @@aut@@ Alessandro De Toma @@aut@@ Clelia Donisi @@aut@@ Serena Ricciardi @@aut@@ Maria Rita Migliorino @@aut@@ Valerio Maria Napoli @@aut@@ Gianmarco Leone @@aut@@ Giulio Metro @@aut@@ Giuseppe L. Banna @@aut@@ Alex Friedlaender @@aut@@ Alfredo Addeo @@aut@@ Corrado Ficorella @@aut@@ Giampiero Porzio @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	629836809
id	DOAJ04962752X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ04962752X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503021803.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/1759-7714.13852</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ04962752X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Alessio Cortellini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">immunotherapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">non‐small cell lung cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">pembrolizumab</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">smoking</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">tobacco</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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callnumber-first	R - Medicine
author	Alessio Cortellini
spellingShingle	Alessio Cortellini misc RC254-282 misc immunotherapy misc non‐small cell lung cancer misc pembrolizumab misc smoking misc tobacco misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
authorStr	Alessio Cortellini
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callnumber-label	RC254-282
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issn	17597714
topic_title	RC254-282 Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study immunotherapy non‐small cell lung cancer pembrolizumab smoking tobacco
topic	misc RC254-282 misc immunotherapy misc non‐small cell lung cancer misc pembrolizumab misc smoking misc tobacco misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc immunotherapy misc non‐small cell lung cancer misc pembrolizumab misc smoking misc tobacco misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc immunotherapy misc non‐small cell lung cancer misc pembrolizumab misc smoking misc tobacco misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
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title_full	Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
author_sort	Alessio Cortellini
journal	Thoracic Cancer
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author_browse	Alessio Cortellini Andrea De Giglio Katia Cannita Diego L. Cortinovis Robin Cornelissen Cinzia Baldessari Raffaele Giusti Ettore D'Argento Francesco Grossi Matteo Santoni Annamaria Catino Rossana Berardi Vincenzo Sforza Giovanni Rossi Lorenzo Antonuzzo Vincenzo Di Noia Diego Signorelli Alain Gelibter Mario Alberto Occhipinti Alessandro Follador Francesca Rastelli Rita Chiari Luigi Della Gravara Alessandro Inno Michele De Tursi Pietro Di Marino Giovanni Mansueto Federica Zoratto Marco Filetti Michele Montrone Fabrizio Citarella Maria Vittoria Pensieri Marco Russano Luca Cantini Olga Nigro Alessandro Leonetti Paola Bordi Gabriele Minuti Lorenza Landi Alessandro De Toma Clelia Donisi Serena Ricciardi Maria Rita Migliorino Valerio Maria Napoli Gianmarco Leone Giulio Metro Giuseppe L. Banna Alex Friedlaender Alfredo Addeo Corrado Ficorella Giampiero Porzio
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author-letter	Alessio Cortellini
doi_str_mv	10.1111/1759-7714.13852
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title_sort	smoking status during first‐line immunotherapy and chemotherapy in nsclc patients: a case–control matched analysis from a large multicenter study
callnumber	RC254-282
title_auth	Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
abstract	Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy.
abstractGer	Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy.
abstract_unstemmed	Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. On the contrary, worse outcomes were reported among current/former smokers receiving first‐line chemotherapy.
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container_issue	6
title_short	Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study
url	https://doi.org/10.1111/1759-7714.13852 https://doaj.org/article/c7f53a01da6942bfa7ce73222085c5cd https://doaj.org/toc/1759-7706 https://doaj.org/toc/1759-7714
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author2	Andrea De Giglio Katia Cannita Diego L. Cortinovis Robin Cornelissen Cinzia Baldessari Raffaele Giusti Ettore D'Argento Francesco Grossi Matteo Santoni Annamaria Catino Rossana Berardi Vincenzo Sforza Giovanni Rossi Lorenzo Antonuzzo Vincenzo Di Noia Diego Signorelli Alain Gelibter Mario Alberto Occhipinti Alessandro Follador Francesca Rastelli Rita Chiari Luigi Della Gravara Alessandro Inno Michele De Tursi Pietro Di Marino Giovanni Mansueto Federica Zoratto Marco Filetti Michele Montrone Fabrizio Citarella Maria Vittoria Pensieri Marco Russano Luca Cantini Olga Nigro Alessandro Leonetti Paola Bordi Gabriele Minuti Lorenza Landi Alessandro De Toma Clelia Donisi Serena Ricciardi Maria Rita Migliorino Valerio Maria Napoli Gianmarco Leone Giulio Metro Giuseppe L. Banna Alex Friedlaender Alfredo Addeo Corrado Ficorella Giampiero Porzio
author2Str	Andrea De Giglio Katia Cannita Diego L. Cortinovis Robin Cornelissen Cinzia Baldessari Raffaele Giusti Ettore D'Argento Francesco Grossi Matteo Santoni Annamaria Catino Rossana Berardi Vincenzo Sforza Giovanni Rossi Lorenzo Antonuzzo Vincenzo Di Noia Diego Signorelli Alain Gelibter Mario Alberto Occhipinti Alessandro Follador Francesca Rastelli Rita Chiari Luigi Della Gravara Alessandro Inno Michele De Tursi Pietro Di Marino Giovanni Mansueto Federica Zoratto Marco Filetti Michele Montrone Fabrizio Citarella Maria Vittoria Pensieri Marco Russano Luca Cantini Olga Nigro Alessandro Leonetti Paola Bordi Gabriele Minuti Lorenza Landi Alessandro De Toma Clelia Donisi Serena Ricciardi Maria Rita Migliorino Valerio Maria Napoli Gianmarco Leone Giulio Metro Giuseppe L. Banna Alex Friedlaender Alfredo Addeo Corrado Ficorella Giampiero Porzio
ppnlink	629836809
callnumber-subject	RC - Internal Medicine
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doi_str	10.1111/1759-7714.13852
callnumber-a	RC254-282
up_date	2024-07-04T00:09:39.691Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ04962752X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503021803.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/1759-7714.13852</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ04962752X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJc7f53a01da6942bfa7ce73222085c5cd</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Alessio Cortellini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Improved outcome in tobacco smoking patients with non‐small cell lung cancer (NSCLC) following immunotherapy has previously been reported. However, little is known regarding this association during first‐line immunotherapy in patients with high PD‐L1 expression. In this study we compared clinical outcomes according to the smoking status of two large multicenter cohorts. Methods We compared clinical outcomes according to the smoking status (never smokers vs. current/former smokers) of two retrospective multicenter cohorts of metastatic NSCLC patients, treated with first‐line pembrolizumab and platinum‐based chemotherapy. Results A total of 962 NSCLC patients with PD‐L1 expression ≥50% who received first‐line pembrolizumab and 462 NSCLC patients who received first‐line platinum‐based chemotherapy were included in the study. Never smokers were confirmed to have a significantly higher risk of disease progression (hazard ratio [HR] = 1.49 [95% CI: 1.15–1.92], p = 0.0022) and death (HR = 1.38 [95% CI: 1.02–1.87], p = 0.0348) within the pembrolizumab cohort. On the contrary, a nonsignificant trend towards a reduced risk of disease progression (HR = 0.74 [95% CI: 0.52–1.05], p = 0.1003) and death (HR = 0.67 [95% CI: 0.45–1.01], p = 0.0593) were reported for never smokers within the chemotherapy cohort. After a random case–control matching, 424 patients from both cohorts were paired. Within the matched pembrolizumab cohort, never smokers had a significantly shorter progression‐free survival (PFS) (HR = 1.68 [95% CI: 1.17–2.40], p = 0.0045) and a nonsignificant trend towards a shortened overall survival (OS) (HR = 1.32 [95% CI: 0.84–2.07], p = 0.2205). On the contrary, never smokers had a significantly longer PFS (HR = 0.68 [95% CI: 0.49–0.95], p = 0.0255) and OS (HR = 0.66 [95% CI: 0.45–0.97], p = 0,0356) compared to current/former smoker patients within the matched chemotherapy cohort. On pooled multivariable analysis, the interaction term between smoking status and treatment modality was concordantly statistically significant with respect to ORR (p = 0.0074), PFS (p = 0.0001) and OS (p = 0.0020), confirming the significantly different impact of smoking status across the two cohorts. Conclusions Among metastatic NSCLC patients with PD‐L1 expression ≥50% receiving first‐line pembrolizumab, current/former smokers experienced improved PFS and OS. 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