Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial
Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance o...
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Gespeichert in:
| Autor*in: |
L Ia Rozhinskaia [verfasserIn] S D Arapova [verfasserIn] L K Dzeranova [verfasserIn] N N Molitvoslovova [verfasserIn] E I Marova [verfasserIn] A V Il'in [verfasserIn] L I Benevolenskaia [verfasserIn] O A Nikitinskaia [verfasserIn] T A Korotkova [verfasserIn] N V Toroptsova [verfasserIn] A V Smirnov [verfasserIn] N V Demin [verfasserIn] S S Rodionova [verfasserIn] Iu V Buklemeshev [verfasserIn] A A Shumskiĭ [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Терапевтический архив - "Consilium Medicum" Publishing house, 2018, 80(2008), 5, Seite 47-52 |
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| Übergeordnetes Werk: |
volume:80 ; year:2008 ; number:5 ; pages:47-52 |
| Links: |
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| Katalog-ID: |
DOAJ049764144 |
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| 520 | |a Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. | ||
| 650 | 4 | |a osteoporosis | |
| 650 | 4 | |a postmenopausal period | |
| 650 | 4 | |a treatment | |
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| 650 | 4 | |a strontium ranelat | |
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(DE-627)DOAJ049764144 (DE-599)DOAJ2645f71983a64216949b015870305230 DE-627 ger DE-627 rakwb rus L Ia Rozhinskaia verfasserin aut Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. osteoporosis postmenopausal period treatment bivalos strontium ranelat Medicine R S D Arapova verfasserin aut L K Dzeranova verfasserin aut N N Molitvoslovova verfasserin aut E I Marova verfasserin aut A V Il'in verfasserin aut L I Benevolenskaia verfasserin aut O A Nikitinskaia verfasserin aut T A Korotkova verfasserin aut N V Toroptsova verfasserin aut A V Smirnov verfasserin aut N V Demin verfasserin aut S S Rodionova verfasserin aut Iu V Buklemeshev verfasserin aut A A Shumskiĭ verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 80(2008), 5, Seite 47-52 (DE-627)1760620270 23095342 nnns volume:80 year:2008 number:5 pages:47-52 https://doaj.org/article/2645f71983a64216949b015870305230 kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30170 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 80 2008 5 47-52 |
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(DE-627)DOAJ049764144 (DE-599)DOAJ2645f71983a64216949b015870305230 DE-627 ger DE-627 rakwb rus L Ia Rozhinskaia verfasserin aut Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. osteoporosis postmenopausal period treatment bivalos strontium ranelat Medicine R S D Arapova verfasserin aut L K Dzeranova verfasserin aut N N Molitvoslovova verfasserin aut E I Marova verfasserin aut A V Il'in verfasserin aut L I Benevolenskaia verfasserin aut O A Nikitinskaia verfasserin aut T A Korotkova verfasserin aut N V Toroptsova verfasserin aut A V Smirnov verfasserin aut N V Demin verfasserin aut S S Rodionova verfasserin aut Iu V Buklemeshev verfasserin aut A A Shumskiĭ verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 80(2008), 5, Seite 47-52 (DE-627)1760620270 23095342 nnns volume:80 year:2008 number:5 pages:47-52 https://doaj.org/article/2645f71983a64216949b015870305230 kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30170 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 80 2008 5 47-52 |
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(DE-627)DOAJ049764144 (DE-599)DOAJ2645f71983a64216949b015870305230 DE-627 ger DE-627 rakwb rus L Ia Rozhinskaia verfasserin aut Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. osteoporosis postmenopausal period treatment bivalos strontium ranelat Medicine R S D Arapova verfasserin aut L K Dzeranova verfasserin aut N N Molitvoslovova verfasserin aut E I Marova verfasserin aut A V Il'in verfasserin aut L I Benevolenskaia verfasserin aut O A Nikitinskaia verfasserin aut T A Korotkova verfasserin aut N V Toroptsova verfasserin aut A V Smirnov verfasserin aut N V Demin verfasserin aut S S Rodionova verfasserin aut Iu V Buklemeshev verfasserin aut A A Shumskiĭ verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 80(2008), 5, Seite 47-52 (DE-627)1760620270 23095342 nnns volume:80 year:2008 number:5 pages:47-52 https://doaj.org/article/2645f71983a64216949b015870305230 kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30170 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 80 2008 5 47-52 |
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(DE-627)DOAJ049764144 (DE-599)DOAJ2645f71983a64216949b015870305230 DE-627 ger DE-627 rakwb rus L Ia Rozhinskaia verfasserin aut Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. osteoporosis postmenopausal period treatment bivalos strontium ranelat Medicine R S D Arapova verfasserin aut L K Dzeranova verfasserin aut N N Molitvoslovova verfasserin aut E I Marova verfasserin aut A V Il'in verfasserin aut L I Benevolenskaia verfasserin aut O A Nikitinskaia verfasserin aut T A Korotkova verfasserin aut N V Toroptsova verfasserin aut A V Smirnov verfasserin aut N V Demin verfasserin aut S S Rodionova verfasserin aut Iu V Buklemeshev verfasserin aut A A Shumskiĭ verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 80(2008), 5, Seite 47-52 (DE-627)1760620270 23095342 nnns volume:80 year:2008 number:5 pages:47-52 https://doaj.org/article/2645f71983a64216949b015870305230 kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30170 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 80 2008 5 47-52 |
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(DE-627)DOAJ049764144 (DE-599)DOAJ2645f71983a64216949b015870305230 DE-627 ger DE-627 rakwb rus L Ia Rozhinskaia verfasserin aut Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. osteoporosis postmenopausal period treatment bivalos strontium ranelat Medicine R S D Arapova verfasserin aut L K Dzeranova verfasserin aut N N Molitvoslovova verfasserin aut E I Marova verfasserin aut A V Il'in verfasserin aut L I Benevolenskaia verfasserin aut O A Nikitinskaia verfasserin aut T A Korotkova verfasserin aut N V Toroptsova verfasserin aut A V Smirnov verfasserin aut N V Demin verfasserin aut S S Rodionova verfasserin aut Iu V Buklemeshev verfasserin aut A A Shumskiĭ verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 80(2008), 5, Seite 47-52 (DE-627)1760620270 23095342 nnns volume:80 year:2008 number:5 pages:47-52 https://doaj.org/article/2645f71983a64216949b015870305230 kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30170 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 80 2008 5 47-52 |
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To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. 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efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial |
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Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. results of russian multicenter trial |
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Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. |
| abstractGer |
Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. |
| abstract_unstemmed |
Aim. To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods. The study was made of 60 females aged 54-75 years with PMO. MBD was measured with x-ray absorptiometry in the vertebra and proximal femur. Bone markers in blood serum were detected by enzyme immunoassay . Results. After a year of taking bivalos MBD in lumbar vertebra increased by 4.68 ± 4.94%, in the neck of the femur - by 2.0 ± 4.29%, in the proximal femur - by 3.10 ± 3.34%. A significant 19.5% rise in bone alkaline phosphatase and a 16.5% fall in the level of CT were noted showing a stimulating effect of bivalos on bone formation and an inhibiting effect - on bone tissue resorption. Bivalos treatment raised quality of life of the patients: better motility, regress of depression, improved self-appraisal, decreased number of patients with pain in the spine, attenuated pain. The drug was well tolerated, unwanted effects arose in 15% patients, discontinuation of the drug because of toxicity occurred in 5%. Serious side effects were not observed. Conclusion. Strontium ranelate is effective in PMO and is well tolerated. |
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