Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener

Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who present...
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Autor*in:	Richa Chauhan [verfasserIn] Seema Tyagi [verfasserIn] Sumeet Mirgh [verfasserIn] Priyanka Mishra [verfasserIn] Tulika Seth [verfasserIn] Manoranjan Mahapatra [verfasserIn] Haraprasad Pati [verfasserIn] Renu Saxena [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	CD3 hepatosplenic lymphoma

Übergeordnetes Werk:	In: Indian Journal of Pathology and Microbiology - Wolters Kluwer Medknow Publications, 2018, 61(2018), 2, Seite 275-277
Übergeordnetes Werk:	volume:61 ; year:2018 ; number:2 ; pages:275-277

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/IJPM.IJPM_442_17

Katalog-ID:	DOAJ049808044

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spelling	10.4103/IJPM.IJPM_442_17 doi (DE-627)DOAJ049808044 (DE-599)DOAJ8998cab76a324028b643140c310ff675 DE-627 ger DE-627 rakwb eng RB1-214 QR1-502 Richa Chauhan verfasserin aut Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature. CD3 hepatosplenic lymphoma Pathology Microbiology Seema Tyagi verfasserin aut Sumeet Mirgh verfasserin aut Priyanka Mishra verfasserin aut Tulika Seth verfasserin aut Manoranjan Mahapatra verfasserin aut Haraprasad Pati verfasserin aut Renu Saxena verfasserin aut In Indian Journal of Pathology and Microbiology Wolters Kluwer Medknow Publications, 2018 61(2018), 2, Seite 275-277 (DE-627)585798079 (DE-600)2467104-6 09745130 nnns volume:61 year:2018 number:2 pages:275-277 https://doi.org/10.4103/IJPM.IJPM_442_17 kostenfrei https://doaj.org/article/8998cab76a324028b643140c310ff675 kostenfrei http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=275;epage=277;aulast=Chauhan kostenfrei https://doaj.org/toc/0377-4929 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 61 2018 2 275-277
allfields_unstemmed	10.4103/IJPM.IJPM_442_17 doi (DE-627)DOAJ049808044 (DE-599)DOAJ8998cab76a324028b643140c310ff675 DE-627 ger DE-627 rakwb eng RB1-214 QR1-502 Richa Chauhan verfasserin aut Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature. CD3 hepatosplenic lymphoma Pathology Microbiology Seema Tyagi verfasserin aut Sumeet Mirgh verfasserin aut Priyanka Mishra verfasserin aut Tulika Seth verfasserin aut Manoranjan Mahapatra verfasserin aut Haraprasad Pati verfasserin aut Renu Saxena verfasserin aut In Indian Journal of Pathology and Microbiology Wolters Kluwer Medknow Publications, 2018 61(2018), 2, Seite 275-277 (DE-627)585798079 (DE-600)2467104-6 09745130 nnns volume:61 year:2018 number:2 pages:275-277 https://doi.org/10.4103/IJPM.IJPM_442_17 kostenfrei https://doaj.org/article/8998cab76a324028b643140c310ff675 kostenfrei http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=275;epage=277;aulast=Chauhan kostenfrei https://doaj.org/toc/0377-4929 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 61 2018 2 275-277
allfieldsGer	10.4103/IJPM.IJPM_442_17 doi (DE-627)DOAJ049808044 (DE-599)DOAJ8998cab76a324028b643140c310ff675 DE-627 ger DE-627 rakwb eng RB1-214 QR1-502 Richa Chauhan verfasserin aut Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature. CD3 hepatosplenic lymphoma Pathology Microbiology Seema Tyagi verfasserin aut Sumeet Mirgh verfasserin aut Priyanka Mishra verfasserin aut Tulika Seth verfasserin aut Manoranjan Mahapatra verfasserin aut Haraprasad Pati verfasserin aut Renu Saxena verfasserin aut In Indian Journal of Pathology and Microbiology Wolters Kluwer Medknow Publications, 2018 61(2018), 2, Seite 275-277 (DE-627)585798079 (DE-600)2467104-6 09745130 nnns volume:61 year:2018 number:2 pages:275-277 https://doi.org/10.4103/IJPM.IJPM_442_17 kostenfrei https://doaj.org/article/8998cab76a324028b643140c310ff675 kostenfrei http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=275;epage=277;aulast=Chauhan kostenfrei https://doaj.org/toc/0377-4929 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 61 2018 2 275-277
allfieldsSound	10.4103/IJPM.IJPM_442_17 doi (DE-627)DOAJ049808044 (DE-599)DOAJ8998cab76a324028b643140c310ff675 DE-627 ger DE-627 rakwb eng RB1-214 QR1-502 Richa Chauhan verfasserin aut Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature. CD3 hepatosplenic lymphoma Pathology Microbiology Seema Tyagi verfasserin aut Sumeet Mirgh verfasserin aut Priyanka Mishra verfasserin aut Tulika Seth verfasserin aut Manoranjan Mahapatra verfasserin aut Haraprasad Pati verfasserin aut Renu Saxena verfasserin aut In Indian Journal of Pathology and Microbiology Wolters Kluwer Medknow Publications, 2018 61(2018), 2, Seite 275-277 (DE-627)585798079 (DE-600)2467104-6 09745130 nnns volume:61 year:2018 number:2 pages:275-277 https://doi.org/10.4103/IJPM.IJPM_442_17 kostenfrei https://doaj.org/article/8998cab76a324028b643140c310ff675 kostenfrei http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=275;epage=277;aulast=Chauhan kostenfrei https://doaj.org/toc/0377-4929 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 61 2018 2 275-277
language	English
source	In Indian Journal of Pathology and Microbiology 61(2018), 2, Seite 275-277 volume:61 year:2018 number:2 pages:275-277
sourceStr	In Indian Journal of Pathology and Microbiology 61(2018), 2, Seite 275-277 volume:61 year:2018 number:2 pages:275-277
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CD3 hepatosplenic lymphoma Pathology Microbiology
isfreeaccess_bool	true
container_title	Indian Journal of Pathology and Microbiology
authorswithroles_txt_mv	Richa Chauhan @@aut@@ Seema Tyagi @@aut@@ Sumeet Mirgh @@aut@@ Priyanka Mishra @@aut@@ Tulika Seth @@aut@@ Manoranjan Mahapatra @@aut@@ Haraprasad Pati @@aut@@ Renu Saxena @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	585798079
id	DOAJ049808044
language_de	englisch
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callnumber-first	R - Medicine
author	Richa Chauhan
spellingShingle	Richa Chauhan misc RB1-214 misc QR1-502 misc CD3 misc hepatosplenic misc lymphoma misc Pathology misc Microbiology Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
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topic_title	RB1-214 QR1-502 Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener CD3 hepatosplenic lymphoma
topic	misc RB1-214 misc QR1-502 misc CD3 misc hepatosplenic misc lymphoma misc Pathology misc Microbiology
topic_unstemmed	misc RB1-214 misc QR1-502 misc CD3 misc hepatosplenic misc lymphoma misc Pathology misc Microbiology
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title	Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
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title_full	Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
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author_browse	Richa Chauhan Seema Tyagi Sumeet Mirgh Priyanka Mishra Tulika Seth Manoranjan Mahapatra Haraprasad Pati Renu Saxena
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title_sort	expect the unexpected – loss of surface cd3 on flow cytometry in hepatosplenic t-cell lymphoma: an eye opener
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title_auth	Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
abstract	Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature.
abstractGer	Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature.
abstract_unstemmed	Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature.
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title_short	Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
url	https://doi.org/10.4103/IJPM.IJPM_442_17 https://doaj.org/article/8998cab76a324028b643140c310ff675 http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=275;epage=277;aulast=Chauhan https://doaj.org/toc/0377-4929
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up_date	2024-07-04T00:53:42.127Z
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