Encoding of emotion-paired spatial stimuli in the rodent hippocampus

Rats can acquire the cognitive component of CS-US associations between sensory and aversive stimuli without a functional basolateral amygdala. Thus, other brain regions should support such associations. Some septal/dorsal CA1 (dCA1) neurons respond to both spatial stimuli and footshock, suggesting t...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rebecca eNalloor [verfasserIn] Kristopher M Bunting [verfasserIn] Almira eVazdarjanova [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Fear conditioning Emotional Memory Arc Homer 1a ventral CA1 ventral CA3

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 6(2012)
Übergeordnetes Werk:	volume:6 ; year:2012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2012.00027

Katalog-ID:	DOAJ049854275

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language	English
source	In Frontiers in Behavioral Neuroscience 6(2012) volume:6 year:2012
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topic_facet	Fear conditioning Emotional Memory Arc Homer 1a ventral CA1 ventral CA3 Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Behavioral Neuroscience
authorswithroles_txt_mv	Rebecca eNalloor @@aut@@ Kristopher M Bunting @@aut@@ Almira eVazdarjanova @@aut@@
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callnumber-first	R - Medicine
author	Rebecca eNalloor
spellingShingle	Rebecca eNalloor misc RC321-571 misc Fear conditioning misc Emotional Memory misc Arc misc Homer 1a misc ventral CA1 misc ventral CA3 misc Neurosciences. Biological psychiatry. Neuropsychiatry Encoding of emotion-paired spatial stimuli in the rodent hippocampus
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topic_title	RC321-571 Encoding of emotion-paired spatial stimuli in the rodent hippocampus Fear conditioning Emotional Memory Arc Homer 1a ventral CA1 ventral CA3
topic	misc RC321-571 misc Fear conditioning misc Emotional Memory misc Arc misc Homer 1a misc ventral CA1 misc ventral CA3 misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Fear conditioning misc Emotional Memory misc Arc misc Homer 1a misc ventral CA1 misc ventral CA3 misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Encoding of emotion-paired spatial stimuli in the rodent hippocampus
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title_full	Encoding of emotion-paired spatial stimuli in the rodent hippocampus
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title_sort	encoding of emotion-paired spatial stimuli in the rodent hippocampus
callnumber	RC321-571
title_auth	Encoding of emotion-paired spatial stimuli in the rodent hippocampus
abstract	Rats can acquire the cognitive component of CS-US associations between sensory and aversive stimuli without a functional basolateral amygdala. Thus, other brain regions should support such associations. Some septal/dorsal CA1 (dCA1) neurons respond to both spatial stimuli and footshock, suggesting that dCA1 could be one such region. We report that, in both dorsal and ventral hippocampus, different neuronal ensembles express immediate-early genes when a place is experienced alone vs. when it is associated with foot shock. We assessed changes in the size and overlap of hippocampal neuronal ensembles activated by two behavioral events using a cellular imaging method, Arc/Homer1a catFISH. The control group (A-A) experienced the same place twice, while the experimental group (A-CFC) received the same training plus two foot shocks during the second event. During fear conditioning, A-CFC, compared to A-A, rats had a smaller ensemble size in dCA3, dCA1 and vCA3, but not vCA1. Additionally, A-CFC rats had a lower overlap score in dCA1 and vCA3. Locomotion did not correlate with ensemble size. Importantly, foot shocks delivered in a training paradigm that prevents establishing shock-context associations, did not induce significant Arc expression, rejecting the possibility that the observed changes in ensemble size and composition simply reflect experiencing a foot shock. Combined with data that Arc is necessary for lasting synaptic plasticity and long-term memory, the data suggests that Arc/H1a+ hippocampal neuronal ensembles encode aspects of fear conditioning beyond space and time. Rats, like humans, may use the hippocampus to create integrated episodic-like memory during fear conditioning.
abstractGer	Rats can acquire the cognitive component of CS-US associations between sensory and aversive stimuli without a functional basolateral amygdala. Thus, other brain regions should support such associations. Some septal/dorsal CA1 (dCA1) neurons respond to both spatial stimuli and footshock, suggesting that dCA1 could be one such region. We report that, in both dorsal and ventral hippocampus, different neuronal ensembles express immediate-early genes when a place is experienced alone vs. when it is associated with foot shock. We assessed changes in the size and overlap of hippocampal neuronal ensembles activated by two behavioral events using a cellular imaging method, Arc/Homer1a catFISH. The control group (A-A) experienced the same place twice, while the experimental group (A-CFC) received the same training plus two foot shocks during the second event. During fear conditioning, A-CFC, compared to A-A, rats had a smaller ensemble size in dCA3, dCA1 and vCA3, but not vCA1. Additionally, A-CFC rats had a lower overlap score in dCA1 and vCA3. Locomotion did not correlate with ensemble size. Importantly, foot shocks delivered in a training paradigm that prevents establishing shock-context associations, did not induce significant Arc expression, rejecting the possibility that the observed changes in ensemble size and composition simply reflect experiencing a foot shock. Combined with data that Arc is necessary for lasting synaptic plasticity and long-term memory, the data suggests that Arc/H1a+ hippocampal neuronal ensembles encode aspects of fear conditioning beyond space and time. Rats, like humans, may use the hippocampus to create integrated episodic-like memory during fear conditioning.
abstract_unstemmed	Rats can acquire the cognitive component of CS-US associations between sensory and aversive stimuli without a functional basolateral amygdala. Thus, other brain regions should support such associations. Some septal/dorsal CA1 (dCA1) neurons respond to both spatial stimuli and footshock, suggesting that dCA1 could be one such region. We report that, in both dorsal and ventral hippocampus, different neuronal ensembles express immediate-early genes when a place is experienced alone vs. when it is associated with foot shock. We assessed changes in the size and overlap of hippocampal neuronal ensembles activated by two behavioral events using a cellular imaging method, Arc/Homer1a catFISH. The control group (A-A) experienced the same place twice, while the experimental group (A-CFC) received the same training plus two foot shocks during the second event. During fear conditioning, A-CFC, compared to A-A, rats had a smaller ensemble size in dCA3, dCA1 and vCA3, but not vCA1. Additionally, A-CFC rats had a lower overlap score in dCA1 and vCA3. Locomotion did not correlate with ensemble size. Importantly, foot shocks delivered in a training paradigm that prevents establishing shock-context associations, did not induce significant Arc expression, rejecting the possibility that the observed changes in ensemble size and composition simply reflect experiencing a foot shock. Combined with data that Arc is necessary for lasting synaptic plasticity and long-term memory, the data suggests that Arc/H1a+ hippocampal neuronal ensembles encode aspects of fear conditioning beyond space and time. Rats, like humans, may use the hippocampus to create integrated episodic-like memory during fear conditioning.
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title_short	Encoding of emotion-paired spatial stimuli in the rodent hippocampus
url	https://doi.org/10.3389/fnbeh.2012.00027 https://doaj.org/article/3476959a59d24642a1dda7d5c9b3bbbd http://journal.frontiersin.org/Journal/10.3389/fnbeh.2012.00027/full https://doaj.org/toc/1662-5153
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Encoding of emotion-paired spatial stimuli in the rodent hippocampus

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