Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls

<p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Fin...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Robson Mark [verfasserIn] Satagopan Jaya [verfasserIn] Huang Helen [verfasserIn] Yossepowitch Orit [verfasserIn] Johnson Steven [verfasserIn] Gregersen Peter [verfasserIn] Rapaport Beth [verfasserIn] Kolachana Prema [verfasserIn] Kirchhoff Tomas [verfasserIn] Pierce Heather [verfasserIn] Offit Kenneth [verfasserIn] Scheuer Lauren [verfasserIn] Nafa Khedoudja [verfasserIn] Ellis Nathan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Übergeordnetes Werk:	In: BMC Medical Genetics - BMC, 2003, 4(2003), 1, p 1
Übergeordnetes Werk:	volume:4 ; year:2003 ; number:1, p 1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2350-4-1

Katalog-ID:	DOAJ049878883

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK21100delC </it<in North American kindreds.</p<
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callnumber-subject-code	RC
publishDate	2003
allfields	10.1186/1471-2350-4-1 doi (DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Robson Mark verfasserin aut Frequency of <it<CHEK21100delC</it< in New York breast cancer cases and controls 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK2*1100delC </it<in North American kindreds.</p< Internal medicine Genetics Satagopan Jaya verfasserin aut Huang Helen verfasserin aut Yossepowitch Orit verfasserin aut Johnson Steven verfasserin aut Gregersen Peter verfasserin aut Rapaport Beth verfasserin aut Kolachana Prema verfasserin aut Kirchhoff Tomas verfasserin aut Pierce Heather verfasserin aut Offit Kenneth verfasserin aut Scheuer Lauren verfasserin aut Nafa Khedoudja verfasserin aut Ellis Nathan verfasserin aut In BMC Medical Genetics BMC, 2003 4(2003), 1, p 1 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:4 year:2003 number:1, p 1 https://doi.org/10.1186/1471-2350-4-1 kostenfrei https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d kostenfrei http://www.biomedcentral.com/1471-2350/4/1 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 1
spelling	10.1186/1471-2350-4-1 doi (DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Robson Mark verfasserin aut Frequency of <it<CHEK21100delC</it< in New York breast cancer cases and controls 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK2*1100delC </it<in North American kindreds.</p< Internal medicine Genetics Satagopan Jaya verfasserin aut Huang Helen verfasserin aut Yossepowitch Orit verfasserin aut Johnson Steven verfasserin aut Gregersen Peter verfasserin aut Rapaport Beth verfasserin aut Kolachana Prema verfasserin aut Kirchhoff Tomas verfasserin aut Pierce Heather verfasserin aut Offit Kenneth verfasserin aut Scheuer Lauren verfasserin aut Nafa Khedoudja verfasserin aut Ellis Nathan verfasserin aut In BMC Medical Genetics BMC, 2003 4(2003), 1, p 1 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:4 year:2003 number:1, p 1 https://doi.org/10.1186/1471-2350-4-1 kostenfrei https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d kostenfrei http://www.biomedcentral.com/1471-2350/4/1 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 1
allfields_unstemmed	10.1186/1471-2350-4-1 doi (DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Robson Mark verfasserin aut Frequency of <it<CHEK21100delC</it< in New York breast cancer cases and controls 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK2*1100delC </it<in North American kindreds.</p< Internal medicine Genetics Satagopan Jaya verfasserin aut Huang Helen verfasserin aut Yossepowitch Orit verfasserin aut Johnson Steven verfasserin aut Gregersen Peter verfasserin aut Rapaport Beth verfasserin aut Kolachana Prema verfasserin aut Kirchhoff Tomas verfasserin aut Pierce Heather verfasserin aut Offit Kenneth verfasserin aut Scheuer Lauren verfasserin aut Nafa Khedoudja verfasserin aut Ellis Nathan verfasserin aut In BMC Medical Genetics BMC, 2003 4(2003), 1, p 1 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:4 year:2003 number:1, p 1 https://doi.org/10.1186/1471-2350-4-1 kostenfrei https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d kostenfrei http://www.biomedcentral.com/1471-2350/4/1 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 1
allfieldsGer	10.1186/1471-2350-4-1 doi (DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Robson Mark verfasserin aut Frequency of <it<CHEK21100delC</it< in New York breast cancer cases and controls 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK2*1100delC </it<in North American kindreds.</p< Internal medicine Genetics Satagopan Jaya verfasserin aut Huang Helen verfasserin aut Yossepowitch Orit verfasserin aut Johnson Steven verfasserin aut Gregersen Peter verfasserin aut Rapaport Beth verfasserin aut Kolachana Prema verfasserin aut Kirchhoff Tomas verfasserin aut Pierce Heather verfasserin aut Offit Kenneth verfasserin aut Scheuer Lauren verfasserin aut Nafa Khedoudja verfasserin aut Ellis Nathan verfasserin aut In BMC Medical Genetics BMC, 2003 4(2003), 1, p 1 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:4 year:2003 number:1, p 1 https://doi.org/10.1186/1471-2350-4-1 kostenfrei https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d kostenfrei http://www.biomedcentral.com/1471-2350/4/1 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 1
allfieldsSound	10.1186/1471-2350-4-1 doi (DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Robson Mark verfasserin aut Frequency of <it<CHEK21100delC</it< in New York breast cancer cases and controls 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK2*1100delC </it<in North American kindreds.</p< Internal medicine Genetics Satagopan Jaya verfasserin aut Huang Helen verfasserin aut Yossepowitch Orit verfasserin aut Johnson Steven verfasserin aut Gregersen Peter verfasserin aut Rapaport Beth verfasserin aut Kolachana Prema verfasserin aut Kirchhoff Tomas verfasserin aut Pierce Heather verfasserin aut Offit Kenneth verfasserin aut Scheuer Lauren verfasserin aut Nafa Khedoudja verfasserin aut Ellis Nathan verfasserin aut In BMC Medical Genetics BMC, 2003 4(2003), 1, p 1 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:4 year:2003 number:1, p 1 https://doi.org/10.1186/1471-2350-4-1 kostenfrei https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d kostenfrei http://www.biomedcentral.com/1471-2350/4/1 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 1
language	English
source	In BMC Medical Genetics 4(2003), 1, p 1 volume:4 year:2003 number:1, p 1
sourceStr	In BMC Medical Genetics 4(2003), 1, p 1 volume:4 year:2003 number:1, p 1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Internal medicine Genetics
isfreeaccess_bool	true
container_title	BMC Medical Genetics
authorswithroles_txt_mv	Robson Mark @@aut@@ Satagopan Jaya @@aut@@ Huang Helen @@aut@@ Yossepowitch Orit @@aut@@ Johnson Steven @@aut@@ Gregersen Peter @@aut@@ Rapaport Beth @@aut@@ Kolachana Prema @@aut@@ Kirchhoff Tomas @@aut@@ Pierce Heather @@aut@@ Offit Kenneth @@aut@@ Scheuer Lauren @@aut@@ Nafa Khedoudja @@aut@@ Ellis Nathan @@aut@@
publishDateDaySort_date	2003-01-01T00:00:00Z
hierarchy_top_id	326643788
id	DOAJ049878883
language_de	englisch
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callnumber-first	R - Medicine
author	Robson Mark
spellingShingle	Robson Mark misc RC31-1245 misc QH426-470 misc Internal medicine misc Genetics Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
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topic_title	RC31-1245 QH426-470 Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
topic	misc RC31-1245 misc QH426-470 misc Internal medicine misc Genetics
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title	Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
ctrlnum	(DE-627)DOAJ049878883 (DE-599)DOAJa5e9aa2ad7844f43888a0e616e957f2d
title_full	Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
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journalStr	BMC Medical Genetics
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author_browse	Robson Mark Satagopan Jaya Huang Helen Yossepowitch Orit Johnson Steven Gregersen Peter Rapaport Beth Kolachana Prema Kirchhoff Tomas Pierce Heather Offit Kenneth Scheuer Lauren Nafa Khedoudja Ellis Nathan
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doi_str_mv	10.1186/1471-2350-4-1
author2-role	verfasserin
title_sort	frequency of <it<chek2*1100delc</it< in new york breast cancer cases and controls
callnumber	RC31-1245
title_auth	Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
abstract	<p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK21100delC </it<in North American kindreds.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK21100delC </it<in North American kindreds.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The <it<1100delC CHEK2 </it<allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of <it<1100delC </it<was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear.</p< <p<Methods</p< <p<We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the <it<CHEK21100delC</it<.</p< <p<Results</p< <p<The overall frequency of the <it<1100delC </it<was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls.</p< <p<Conclusion</p< <p<The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of germline testing for <it<CHEK21100delC </it<in North American kindreds.</p<
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title_short	Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls
url	https://doi.org/10.1186/1471-2350-4-1 https://doaj.org/article/a5e9aa2ad7844f43888a0e616e957f2d http://www.biomedcentral.com/1471-2350/4/1 https://doaj.org/toc/1471-2350
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Frequency of <it<CHEK2*1100delC</it< in New York breast cancer cases and controls

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