Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer

Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-c...
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Autor*in:	Yakup Bozkaya [verfasserIn] Nuriye Yıldırım Özdemir [verfasserIn] Gökmen Umut Erdem [verfasserIn] Ebru Karcı Güner [verfasserIn] Yüksel Ürün [verfasserIn] Nebi Serkan Demirci [verfasserIn] Ozan Yazıcı [verfasserIn] Osman Köstek [verfasserIn] Nurullah Zengin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Journal of Oncological Sciences - Turkiye Klinikleri, 2017, 4(2018), 1, Seite 5-10
Übergeordnetes Werk:	volume:4 ; year:2018 ; number:1 ; pages:5-10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jons.2017.12.004

Katalog-ID:	DOAJ049922076

Internformat


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245	1	0	\|a Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
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520			\|a Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Nuriye Yıldırım Özdemir \|e verfasserin \|4 aut
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700	0		\|a Nurullah Zengin \|e verfasserin \|4 aut
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allfields	10.1016/j.jons.2017.12.004 doi (DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f DE-627 ger DE-627 rakwb eng RC254-282 Yakup Bozkaya verfasserin aut Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nuriye Yıldırım Özdemir verfasserin aut Gökmen Umut Erdem verfasserin aut Ebru Karcı Güner verfasserin aut Yüksel Ürün verfasserin aut Nebi Serkan Demirci verfasserin aut Ozan Yazıcı verfasserin aut Osman Köstek verfasserin aut Nurullah Zengin verfasserin aut In Journal of Oncological Sciences Turkiye Klinikleri, 2017 4(2018), 1, Seite 5-10 (DE-627)860839109 (DE-600)2858461-2 24523364 nnns volume:4 year:2018 number:1 pages:5-10 https://doi.org/10.1016/j.jons.2017.12.004 kostenfrei https://doaj.org/article/70647a291637400dabfdedfe0c13a05f kostenfrei http://www.sciencedirect.com/science/article/pii/S2452336417301097 kostenfrei https://doaj.org/toc/2452-3364 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2018 1 5-10
spelling	10.1016/j.jons.2017.12.004 doi (DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f DE-627 ger DE-627 rakwb eng RC254-282 Yakup Bozkaya verfasserin aut Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nuriye Yıldırım Özdemir verfasserin aut Gökmen Umut Erdem verfasserin aut Ebru Karcı Güner verfasserin aut Yüksel Ürün verfasserin aut Nebi Serkan Demirci verfasserin aut Ozan Yazıcı verfasserin aut Osman Köstek verfasserin aut Nurullah Zengin verfasserin aut In Journal of Oncological Sciences Turkiye Klinikleri, 2017 4(2018), 1, Seite 5-10 (DE-627)860839109 (DE-600)2858461-2 24523364 nnns volume:4 year:2018 number:1 pages:5-10 https://doi.org/10.1016/j.jons.2017.12.004 kostenfrei https://doaj.org/article/70647a291637400dabfdedfe0c13a05f kostenfrei http://www.sciencedirect.com/science/article/pii/S2452336417301097 kostenfrei https://doaj.org/toc/2452-3364 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2018 1 5-10
allfields_unstemmed	10.1016/j.jons.2017.12.004 doi (DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f DE-627 ger DE-627 rakwb eng RC254-282 Yakup Bozkaya verfasserin aut Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nuriye Yıldırım Özdemir verfasserin aut Gökmen Umut Erdem verfasserin aut Ebru Karcı Güner verfasserin aut Yüksel Ürün verfasserin aut Nebi Serkan Demirci verfasserin aut Ozan Yazıcı verfasserin aut Osman Köstek verfasserin aut Nurullah Zengin verfasserin aut In Journal of Oncological Sciences Turkiye Klinikleri, 2017 4(2018), 1, Seite 5-10 (DE-627)860839109 (DE-600)2858461-2 24523364 nnns volume:4 year:2018 number:1 pages:5-10 https://doi.org/10.1016/j.jons.2017.12.004 kostenfrei https://doaj.org/article/70647a291637400dabfdedfe0c13a05f kostenfrei http://www.sciencedirect.com/science/article/pii/S2452336417301097 kostenfrei https://doaj.org/toc/2452-3364 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2018 1 5-10
allfieldsGer	10.1016/j.jons.2017.12.004 doi (DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f DE-627 ger DE-627 rakwb eng RC254-282 Yakup Bozkaya verfasserin aut Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nuriye Yıldırım Özdemir verfasserin aut Gökmen Umut Erdem verfasserin aut Ebru Karcı Güner verfasserin aut Yüksel Ürün verfasserin aut Nebi Serkan Demirci verfasserin aut Ozan Yazıcı verfasserin aut Osman Köstek verfasserin aut Nurullah Zengin verfasserin aut In Journal of Oncological Sciences Turkiye Klinikleri, 2017 4(2018), 1, Seite 5-10 (DE-627)860839109 (DE-600)2858461-2 24523364 nnns volume:4 year:2018 number:1 pages:5-10 https://doi.org/10.1016/j.jons.2017.12.004 kostenfrei https://doaj.org/article/70647a291637400dabfdedfe0c13a05f kostenfrei http://www.sciencedirect.com/science/article/pii/S2452336417301097 kostenfrei https://doaj.org/toc/2452-3364 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2018 1 5-10
allfieldsSound	10.1016/j.jons.2017.12.004 doi (DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f DE-627 ger DE-627 rakwb eng RC254-282 Yakup Bozkaya verfasserin aut Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nuriye Yıldırım Özdemir verfasserin aut Gökmen Umut Erdem verfasserin aut Ebru Karcı Güner verfasserin aut Yüksel Ürün verfasserin aut Nebi Serkan Demirci verfasserin aut Ozan Yazıcı verfasserin aut Osman Köstek verfasserin aut Nurullah Zengin verfasserin aut In Journal of Oncological Sciences Turkiye Klinikleri, 2017 4(2018), 1, Seite 5-10 (DE-627)860839109 (DE-600)2858461-2 24523364 nnns volume:4 year:2018 number:1 pages:5-10 https://doi.org/10.1016/j.jons.2017.12.004 kostenfrei https://doaj.org/article/70647a291637400dabfdedfe0c13a05f kostenfrei http://www.sciencedirect.com/science/article/pii/S2452336417301097 kostenfrei https://doaj.org/toc/2452-3364 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2018 1 5-10
language	English
source	In Journal of Oncological Sciences 4(2018), 1, Seite 5-10 volume:4 year:2018 number:1 pages:5-10
sourceStr	In Journal of Oncological Sciences 4(2018), 1, Seite 5-10 volume:4 year:2018 number:1 pages:5-10
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topic_facet	Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Journal of Oncological Sciences
authorswithroles_txt_mv	Yakup Bozkaya @@aut@@ Nuriye Yıldırım Özdemir @@aut@@ Gökmen Umut Erdem @@aut@@ Ebru Karcı Güner @@aut@@ Yüksel Ürün @@aut@@ Nebi Serkan Demirci @@aut@@ Ozan Yazıcı @@aut@@ Osman Köstek @@aut@@ Nurullah Zengin @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. 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topic_title	RC254-282 Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
ctrlnum	(DE-627)DOAJ049922076 (DE-599)DOAJ70647a291637400dabfdedfe0c13a05f
title_full	Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
author_sort	Yakup Bozkaya
journal	Journal of Oncological Sciences
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author_browse	Yakup Bozkaya Nuriye Yıldırım Özdemir Gökmen Umut Erdem Ebru Karcı Güner Yüksel Ürün Nebi Serkan Demirci Ozan Yazıcı Osman Köstek Nurullah Zengin
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author-letter	Yakup Bozkaya
doi_str_mv	10.1016/j.jons.2017.12.004
author2-role	verfasserin
title_sort	clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
callnumber	RC254-282
title_auth	Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
abstract	Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio
abstractGer	Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio
abstract_unstemmed	Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally advanced rectal cancer and underwent a long-course nCRT, followed by curative surgery between January 2009 and December 2015 at two-center were included. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Two hundred and three patients were included in this study. Forty-six patients (22.7%) had pCR and 157 patients (77.3%) had non-pCR. In the univariate analysis, no smoking history, clinically negative lymp node (cN-), well-differentiated tumor, tumor size of ≤5 cm, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery<8 week were associated with an increased rate of pCR. No smoking history [odds ratio (OR) = 3.382, P = .008], endoscopic tumor size of ≤5 [OR = 2.608, P = .03], cN- [OR = 3.800, P = .002], well-differentiated tumor [OR = 3.566, P = .002], median interval to surgery of <8 week [OR = 2.981, P = .014], and pre-nCRT CEA level of ≤5 (ng/mL) [OR = 3.067, P = .008] were determined to be independent predictive factors of pCR with logistic regression model analysis. Conclusion: No smoking history, cN-, tumor size of ≤5 cm, well-differentiated tumor, pre-nCRT CEA level of ≤5 (ng/mL) and median interval to surgery of <8 weeks were independent clinical predictors for pCR in rectal cancer patients treated with long course of nCRT. This factors may help clinicians predict the prognosis of patients and develop proper treatment approach. Keywords: Pathologic complete response, Neoadjuvant chemoradiotherapy, Locally advanced rectal cancer, Leukocyte/lymphocyte ratio, Platelet/lymphocyte ratio
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title_short	Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer
url	https://doi.org/10.1016/j.jons.2017.12.004 https://doaj.org/article/70647a291637400dabfdedfe0c13a05f http://www.sciencedirect.com/science/article/pii/S2452336417301097 https://doaj.org/toc/2452-3364
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author2Str	Nuriye Yıldırım Özdemir Gökmen Umut Erdem Ebru Karcı Güner Yüksel Ürün Nebi Serkan Demirci Ozan Yazıcı Osman Köstek Nurullah Zengin
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up_date	2024-07-04T01:20:57.742Z
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