Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China

Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ziyi Liu [verfasserIn] Xia Xiao [verfasserIn] Yan Li [verfasserIn] Yuan Liu [verfasserIn] Ruichao Li [verfasserIn] Zhiqiang Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids

Übergeordnetes Werk:	In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmicb.2019.02002

Katalog-ID:	DOAJ049950150

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allfields	10.3389/fmicb.2019.02002 doi (DE-627)DOAJ049950150 (DE-599)DOAJa9d5931830d34d37bee017e41964cd5f DE-627 ger DE-627 rakwb eng QR1-502 Ziyi Liu verfasserin aut Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks. carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids Microbiology Ziyi Liu verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Yan Li verfasserin aut Yan Li verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 10(2019) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:10 year:2019 https://doi.org/10.3389/fmicb.2019.02002 kostenfrei https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
spelling	10.3389/fmicb.2019.02002 doi (DE-627)DOAJ049950150 (DE-599)DOAJa9d5931830d34d37bee017e41964cd5f DE-627 ger DE-627 rakwb eng QR1-502 Ziyi Liu verfasserin aut Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks. carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids Microbiology Ziyi Liu verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Yan Li verfasserin aut Yan Li verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 10(2019) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:10 year:2019 https://doi.org/10.3389/fmicb.2019.02002 kostenfrei https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfields_unstemmed	10.3389/fmicb.2019.02002 doi (DE-627)DOAJ049950150 (DE-599)DOAJa9d5931830d34d37bee017e41964cd5f DE-627 ger DE-627 rakwb eng QR1-502 Ziyi Liu verfasserin aut Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks. carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids Microbiology Ziyi Liu verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Yan Li verfasserin aut Yan Li verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 10(2019) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:10 year:2019 https://doi.org/10.3389/fmicb.2019.02002 kostenfrei https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfieldsGer	10.3389/fmicb.2019.02002 doi (DE-627)DOAJ049950150 (DE-599)DOAJa9d5931830d34d37bee017e41964cd5f DE-627 ger DE-627 rakwb eng QR1-502 Ziyi Liu verfasserin aut Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks. carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids Microbiology Ziyi Liu verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Yan Li verfasserin aut Yan Li verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 10(2019) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:10 year:2019 https://doi.org/10.3389/fmicb.2019.02002 kostenfrei https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfieldsSound	10.3389/fmicb.2019.02002 doi (DE-627)DOAJ049950150 (DE-599)DOAJa9d5931830d34d37bee017e41964cd5f DE-627 ger DE-627 rakwb eng QR1-502 Ziyi Liu verfasserin aut Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks. carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids Microbiology Ziyi Liu verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Xia Xiao verfasserin aut Yan Li verfasserin aut Yan Li verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Yuan Liu verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Ruichao Li verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut Zhiqiang Wang verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 10(2019) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:10 year:2019 https://doi.org/10.3389/fmicb.2019.02002 kostenfrei https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
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callnumber-first	Q - Science
author	Ziyi Liu
spellingShingle	Ziyi Liu misc QR1-502 misc carbapenemase genes misc blaNDM–5 misc E. coli misc long-read sequencing misc plasmids misc Microbiology Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
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topic_title	QR1-502 Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China carbapenemase genes blaNDM–5 E. coli long-read sequencing plasmids
topic	misc QR1-502 misc carbapenemase genes misc blaNDM–5 misc E. coli misc long-read sequencing misc plasmids misc Microbiology
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title	Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
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title_full	Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
author_sort	Ziyi Liu
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title_sort	emergence of incx3 plasmid-harboring blandm–5 dominated by escherichia coli st48 in a goose farm in jiangsu, china
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title_auth	Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
abstract	Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks.
abstractGer	Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks.
abstract_unstemmed	Twelve carbapenem-resistant Escherichia coli strains were obtained from goose farms in Jiangsu, China. These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. Comprehensive surveillance of carbapenem-resistant bacteria in goose farms warrants further study to evaluate the underlying risks.
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title_short	Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China
url	https://doi.org/10.3389/fmicb.2019.02002 https://doaj.org/article/a9d5931830d34d37bee017e41964cd5f https://www.frontiersin.org/article/10.3389/fmicb.2019.02002/full https://doaj.org/toc/1664-302X
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author2	Ziyi Liu Xia Xiao Yan Li Yuan Liu Ruichao Li Zhiqiang Wang
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up_date	2024-07-04T01:27:30.743Z
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These isolates were resistant to multiple antimicrobials, and positive for the blaNDM–5. The carbapenem-resistance of all strains mediated by blaNDM–5 were successfully conjugated to E. coli J53. S1-PFGE and WGS results showed blaNDM–5 was located on IncX3 conjugative plasmids with a size of ca. 46 kb. All blaNDM–5-bearing IncX3 plasmids shared the same genetic context almost identical to pNDM_MGR194-blaNDM–5 and pNDM-QD28-blaNDM–5 reported in India and China, respectively. The twelve strains belonged to three STs, in which the dominant type of E. coli isolated from breeding goose farm carrying blaNDM–5 was ST48. The emergence of blaNDM–5-bearing strains in goose farms and the clonal transmission of E. coli within the breeding goose farm highlighted the potential reservoir of carbapenemase genes in waterfowl farming system, which may further contaminate environments and pose a threat to public health. 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Emergence of IncX3 Plasmid-Harboring blaNDM–5 Dominated by Escherichia coli ST48 in a Goose Farm in Jiangsu, China

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