Analysis of the conservation of synteny between Fugu and human chromosome 12

<p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conser...
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Autor*in:	Koop Ben F [verfasserIn] Chevrette Mario [verfasserIn] Wilson Michael D [verfasserIn] Montpetit Alexandre [verfasserIn] Sinnett Daniel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Übergeordnetes Werk:	In: BMC Genomics - BMC, 2003, 4(2003), 1, p 30
Übergeordnetes Werk:	volume:4 ; year:2003 ; number:1, p 30

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2164-4-30

Katalog-ID:	DOAJ050072560

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allfields	10.1186/1471-2164-4-30 doi (DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Koop Ben F verfasserin aut Analysis of the conservation of synteny between Fugu and human chromosome 12 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p< Biotechnology Genetics Chevrette Mario verfasserin aut Wilson Michael D verfasserin aut Montpetit Alexandre verfasserin aut Sinnett Daniel verfasserin aut In BMC Genomics BMC, 2003 4(2003), 1, p 30 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:4 year:2003 number:1, p 30 https://doi.org/10.1186/1471-2164-4-30 kostenfrei https://doaj.org/article/4b82336e9bbd474693df08b0ea2b9b02 kostenfrei http://www.biomedcentral.com/1471-2164/4/30 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 30
spelling	10.1186/1471-2164-4-30 doi (DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Koop Ben F verfasserin aut Analysis of the conservation of synteny between Fugu and human chromosome 12 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p< Biotechnology Genetics Chevrette Mario verfasserin aut Wilson Michael D verfasserin aut Montpetit Alexandre verfasserin aut Sinnett Daniel verfasserin aut In BMC Genomics BMC, 2003 4(2003), 1, p 30 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:4 year:2003 number:1, p 30 https://doi.org/10.1186/1471-2164-4-30 kostenfrei https://doaj.org/article/4b82336e9bbd474693df08b0ea2b9b02 kostenfrei http://www.biomedcentral.com/1471-2164/4/30 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 30
allfields_unstemmed	10.1186/1471-2164-4-30 doi (DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Koop Ben F verfasserin aut Analysis of the conservation of synteny between Fugu and human chromosome 12 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p< Biotechnology Genetics Chevrette Mario verfasserin aut Wilson Michael D verfasserin aut Montpetit Alexandre verfasserin aut Sinnett Daniel verfasserin aut In BMC Genomics BMC, 2003 4(2003), 1, p 30 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:4 year:2003 number:1, p 30 https://doi.org/10.1186/1471-2164-4-30 kostenfrei https://doaj.org/article/4b82336e9bbd474693df08b0ea2b9b02 kostenfrei http://www.biomedcentral.com/1471-2164/4/30 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 30
allfieldsGer	10.1186/1471-2164-4-30 doi (DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Koop Ben F verfasserin aut Analysis of the conservation of synteny between Fugu and human chromosome 12 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p< Biotechnology Genetics Chevrette Mario verfasserin aut Wilson Michael D verfasserin aut Montpetit Alexandre verfasserin aut Sinnett Daniel verfasserin aut In BMC Genomics BMC, 2003 4(2003), 1, p 30 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:4 year:2003 number:1, p 30 https://doi.org/10.1186/1471-2164-4-30 kostenfrei https://doaj.org/article/4b82336e9bbd474693df08b0ea2b9b02 kostenfrei http://www.biomedcentral.com/1471-2164/4/30 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 30
allfieldsSound	10.1186/1471-2164-4-30 doi (DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Koop Ben F verfasserin aut Analysis of the conservation of synteny between Fugu and human chromosome 12 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p< Biotechnology Genetics Chevrette Mario verfasserin aut Wilson Michael D verfasserin aut Montpetit Alexandre verfasserin aut Sinnett Daniel verfasserin aut In BMC Genomics BMC, 2003 4(2003), 1, p 30 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:4 year:2003 number:1, p 30 https://doi.org/10.1186/1471-2164-4-30 kostenfrei https://doaj.org/article/4b82336e9bbd474693df08b0ea2b9b02 kostenfrei http://www.biomedcentral.com/1471-2164/4/30 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 1, p 30
language	English
source	In BMC Genomics 4(2003), 1, p 30 volume:4 year:2003 number:1, p 30
sourceStr	In BMC Genomics 4(2003), 1, p 30 volume:4 year:2003 number:1, p 30
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biotechnology Genetics
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container_title	BMC Genomics
authorswithroles_txt_mv	Koop Ben F @@aut@@ Chevrette Mario @@aut@@ Wilson Michael D @@aut@@ Montpetit Alexandre @@aut@@ Sinnett Daniel @@aut@@
publishDateDaySort_date	2003-01-01T00:00:00Z
hierarchy_top_id	326644954
id	DOAJ050072560
language_de	englisch
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callnumber-first	T - Technology
author	Koop Ben F
spellingShingle	Koop Ben F misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics Analysis of the conservation of synteny between Fugu and human chromosome 12
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topic_title	TP248.13-248.65 QH426-470 Analysis of the conservation of synteny between Fugu and human chromosome 12
topic	misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics
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title	Analysis of the conservation of synteny between Fugu and human chromosome 12
ctrlnum	(DE-627)DOAJ050072560 (DE-599)DOAJ4b82336e9bbd474693df08b0ea2b9b02
title_full	Analysis of the conservation of synteny between Fugu and human chromosome 12
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author_browse	Koop Ben F Chevrette Mario Wilson Michael D Montpetit Alexandre Sinnett Daniel
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format_se	Elektronische Aufsätze
author-letter	Koop Ben F
doi_str_mv	10.1186/1471-2164-4-30
author2-role	verfasserin
title_sort	analysis of the conservation of synteny between fugu and human chromosome 12
callnumber	TP248.13-248.65
title_auth	Analysis of the conservation of synteny between Fugu and human chromosome 12
abstract	<p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The pufferfish <it<Fugu rubripes </it<(<it<Fugu</it<) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and <it<Fugu </it<genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.</p< <p<Results</p< <p<We investigated approximately 200 kb of the genomic region surrounding the <it<ETV6 </it<locus in <it<Fugu </it<(<it<fETV6</it<) in order to find conserved functional features, such as genes or regulatory regions, that could give insight into the nature of the genes targeted by deletions in human cancer cells. Seven genes were identified near the <it<fETV6 </it<locus. We found that the synteny with human chromosome 12 was conserved, but extensive genomic rearrangements occurred between the <it<Fugu </it<and human <it<ETV6 </it<loci.</p< <p<Conclusion</p< <p<This comparative analysis led to the identification of previously uncharacterized genes in the human genome and some potentially important regulatory sequences as well. This is a good indication that the analysis of the compact <it<Fugu </it<genome will be valuable to identify functional features that have been conserved throughout the evolution of vertebrates.</p<
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title_short	Analysis of the conservation of synteny between Fugu and human chromosome 12
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Analysis of the conservation of synteny between Fugu and human chromosome 12

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