Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

<p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated...
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Autor*in:	Cantone Laura [verfasserIn] Rizzo Giovanna [verfasserIn] Marinelli Barbara [verfasserIn] Angelici Laura [verfasserIn] Bonzini Matteo [verfasserIn] Nordio Francesco [verfasserIn] Tarantini Letizia [verfasserIn] Zhang Xiao [verfasserIn] Hou Lifang [verfasserIn] Apostoli Pietro [verfasserIn] Bertazzi Pier [verfasserIn] Baccarelli Andrea [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: Particle and Fibre Toxicology - BMC, 2004, 8(2011), 1, p 25
Übergeordnetes Werk:	volume:8 ; year:2011 ; number:1, p 25

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1743-8977-8-25

Katalog-ID:	DOAJ050136151

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allfields	10.1186/1743-8977-8-25 doi (DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f DE-627 ger DE-627 rakwb eng RA1190-1270 HD7260-7780.8 Cantone Laura verfasserin aut Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p< Toxicology. Poisons Industrial hygiene. Industrial welfare Rizzo Giovanna verfasserin aut Marinelli Barbara verfasserin aut Angelici Laura verfasserin aut Bonzini Matteo verfasserin aut Nordio Francesco verfasserin aut Tarantini Letizia verfasserin aut Zhang Xiao verfasserin aut Hou Lifang verfasserin aut Apostoli Pietro verfasserin aut Bertazzi Pier verfasserin aut Baccarelli Andrea verfasserin aut In Particle and Fibre Toxicology BMC, 2004 8(2011), 1, p 25 (DE-627)474928276 (DE-600)2170936-1 17438977 nnns volume:8 year:2011 number:1, p 25 https://doi.org/10.1186/1743-8977-8-25 kostenfrei https://doaj.org/article/5167de9506374ce98d31133ef793264f kostenfrei http://www.particleandfibretoxicology.com/content/8/1/25 kostenfrei https://doaj.org/toc/1743-8977 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 25
spelling	10.1186/1743-8977-8-25 doi (DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f DE-627 ger DE-627 rakwb eng RA1190-1270 HD7260-7780.8 Cantone Laura verfasserin aut Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p< Toxicology. Poisons Industrial hygiene. Industrial welfare Rizzo Giovanna verfasserin aut Marinelli Barbara verfasserin aut Angelici Laura verfasserin aut Bonzini Matteo verfasserin aut Nordio Francesco verfasserin aut Tarantini Letizia verfasserin aut Zhang Xiao verfasserin aut Hou Lifang verfasserin aut Apostoli Pietro verfasserin aut Bertazzi Pier verfasserin aut Baccarelli Andrea verfasserin aut In Particle and Fibre Toxicology BMC, 2004 8(2011), 1, p 25 (DE-627)474928276 (DE-600)2170936-1 17438977 nnns volume:8 year:2011 number:1, p 25 https://doi.org/10.1186/1743-8977-8-25 kostenfrei https://doaj.org/article/5167de9506374ce98d31133ef793264f kostenfrei http://www.particleandfibretoxicology.com/content/8/1/25 kostenfrei https://doaj.org/toc/1743-8977 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 25
allfields_unstemmed	10.1186/1743-8977-8-25 doi (DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f DE-627 ger DE-627 rakwb eng RA1190-1270 HD7260-7780.8 Cantone Laura verfasserin aut Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p< Toxicology. Poisons Industrial hygiene. Industrial welfare Rizzo Giovanna verfasserin aut Marinelli Barbara verfasserin aut Angelici Laura verfasserin aut Bonzini Matteo verfasserin aut Nordio Francesco verfasserin aut Tarantini Letizia verfasserin aut Zhang Xiao verfasserin aut Hou Lifang verfasserin aut Apostoli Pietro verfasserin aut Bertazzi Pier verfasserin aut Baccarelli Andrea verfasserin aut In Particle and Fibre Toxicology BMC, 2004 8(2011), 1, p 25 (DE-627)474928276 (DE-600)2170936-1 17438977 nnns volume:8 year:2011 number:1, p 25 https://doi.org/10.1186/1743-8977-8-25 kostenfrei https://doaj.org/article/5167de9506374ce98d31133ef793264f kostenfrei http://www.particleandfibretoxicology.com/content/8/1/25 kostenfrei https://doaj.org/toc/1743-8977 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 25
allfieldsGer	10.1186/1743-8977-8-25 doi (DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f DE-627 ger DE-627 rakwb eng RA1190-1270 HD7260-7780.8 Cantone Laura verfasserin aut Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p< Toxicology. Poisons Industrial hygiene. Industrial welfare Rizzo Giovanna verfasserin aut Marinelli Barbara verfasserin aut Angelici Laura verfasserin aut Bonzini Matteo verfasserin aut Nordio Francesco verfasserin aut Tarantini Letizia verfasserin aut Zhang Xiao verfasserin aut Hou Lifang verfasserin aut Apostoli Pietro verfasserin aut Bertazzi Pier verfasserin aut Baccarelli Andrea verfasserin aut In Particle and Fibre Toxicology BMC, 2004 8(2011), 1, p 25 (DE-627)474928276 (DE-600)2170936-1 17438977 nnns volume:8 year:2011 number:1, p 25 https://doi.org/10.1186/1743-8977-8-25 kostenfrei https://doaj.org/article/5167de9506374ce98d31133ef793264f kostenfrei http://www.particleandfibretoxicology.com/content/8/1/25 kostenfrei https://doaj.org/toc/1743-8977 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 25
allfieldsSound	10.1186/1743-8977-8-25 doi (DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f DE-627 ger DE-627 rakwb eng RA1190-1270 HD7260-7780.8 Cantone Laura verfasserin aut Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p< Toxicology. Poisons Industrial hygiene. Industrial welfare Rizzo Giovanna verfasserin aut Marinelli Barbara verfasserin aut Angelici Laura verfasserin aut Bonzini Matteo verfasserin aut Nordio Francesco verfasserin aut Tarantini Letizia verfasserin aut Zhang Xiao verfasserin aut Hou Lifang verfasserin aut Apostoli Pietro verfasserin aut Bertazzi Pier verfasserin aut Baccarelli Andrea verfasserin aut In Particle and Fibre Toxicology BMC, 2004 8(2011), 1, p 25 (DE-627)474928276 (DE-600)2170936-1 17438977 nnns volume:8 year:2011 number:1, p 25 https://doi.org/10.1186/1743-8977-8-25 kostenfrei https://doaj.org/article/5167de9506374ce98d31133ef793264f kostenfrei http://www.particleandfibretoxicology.com/content/8/1/25 kostenfrei https://doaj.org/toc/1743-8977 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 25
language	English
source	In Particle and Fibre Toxicology 8(2011), 1, p 25 volume:8 year:2011 number:1, p 25
sourceStr	In Particle and Fibre Toxicology 8(2011), 1, p 25 volume:8 year:2011 number:1, p 25
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Toxicology. Poisons Industrial hygiene. Industrial welfare
isfreeaccess_bool	true
container_title	Particle and Fibre Toxicology
authorswithroles_txt_mv	Cantone Laura @@aut@@ Rizzo Giovanna @@aut@@ Marinelli Barbara @@aut@@ Angelici Laura @@aut@@ Bonzini Matteo @@aut@@ Nordio Francesco @@aut@@ Tarantini Letizia @@aut@@ Zhang Xiao @@aut@@ Hou Lifang @@aut@@ Apostoli Pietro @@aut@@ Bertazzi Pier @@aut@@ Baccarelli Andrea @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	474928276
id	DOAJ050136151
language_de	englisch
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Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. 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author	Cantone Laura
spellingShingle	Cantone Laura misc RA1190-1270 misc HD7260-7780.8 misc Toxicology. Poisons misc Industrial hygiene. Industrial welfare Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
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topic_title	RA1190-1270 HD7260-7780.8 Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
topic	misc RA1190-1270 misc HD7260-7780.8 misc Toxicology. Poisons misc Industrial hygiene. Industrial welfare
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title	Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
ctrlnum	(DE-627)DOAJ050136151 (DE-599)DOAJ5167de9506374ce98d31133ef793264f
title_full	Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
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journalStr	Particle and Fibre Toxicology
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author_browse	Cantone Laura Rizzo Giovanna Marinelli Barbara Angelici Laura Bonzini Matteo Nordio Francesco Tarantini Letizia Zhang Xiao Hou Lifang Apostoli Pietro Bertazzi Pier Baccarelli Andrea
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title_sort	ambient pm exposure and dna methylation in tumor suppressor genes: a cross-sectional study
callnumber	RA1190-1270
title_auth	Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
abstract	<p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p<
abstractGer	<p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p<
abstract_unstemmed	<p<Abstract</p< <p<Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. Whether exposure to PM is associated with peripheral blood leukocyte (PBL) DNA methylation in tumor suppressor genes has not been evaluated. In 63 male healthy steel workers with well-characterized exposure to metal-rich particles nearby Brescia, Italy, we evaluated whether exposure to PM and metal components was associated with PBL DNA methylation in 4 tumor suppressor genes (i.e., APC, p16, p53 and RASSF1A). Blood samples were obtained on the 1<sup<st </sup<(baseline) and 4<sup<th </sup<day (post-exposure) of the same work week and DNA methylation was measured using pyrosequencing. A linear mixed model was used to examine the correlations of the exposure with promoter methylation levels. Mean promoter DNA methylation levels of APC or p16 were significantly higher in post-exposure samples compared to that in baseline samples (p-values = 0.005 for APC, and p-value = 0.006 for p16). By contrast, the mean levels of p53 or RASSF1A promoter methylation was decreased in post-exposure samples compared to that in baseline samples (p-value = 0.015 for p53; and p-value < 0.001 for RASSF1A). In post-exposure samples, APC methylation was positively associated with PM<sub<10 </sub<(β = 0.27, 95% CI: 0.13-0.40), and PM<sub<1 </sub<(β = 0.23, 95% CI: 0.09-0.38). In summary, ambient PM exposure was associated with PBL DNA methylation levels of tumor suppressor genes of APC, p16, p53 and RASSF1A, suggesting that such methylation alterations may reflect processes related to PM-induced lung carcinogenesis.</p<
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title_short	Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
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Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

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Zugang & Verfügbarkeit

Vorhandene Bände

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