Near-normal aerobic capacity in long-term survivors after lung transplantation

The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Berta Saez-Gimenez [verfasserIn] Miriam Barrecheguren [verfasserIn] Maria Antònia Ramon [verfasserIn] Alba Gomez-Garrido [verfasserIn] Carlos Bravo [verfasserIn] Víctor Monforte [verfasserIn] Manuel López-Meseguer [verfasserIn] Cristina Berastegui [verfasserIn] Eva Revilla [verfasserIn] Christian Romero [verfasserIn] Rosalía Laporta [verfasserIn] Sonia Fernández-Rozas [verfasserIn] Javier Redel-Montero [verfasserIn] Amparo Solé [verfasserIn] Mercedes de la Torre [verfasserIn] Luis Puente [verfasserIn] Antonio Roman [verfasserIn] Susana Gómez-Ollés [verfasserIn] Iñigo Ojanguren [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: ERJ Open Research - European Respiratory Society, 2015, 7(2021), 1
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1183/23120541.00381-2020

Katalog-ID:	DOAJ050193961

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520			\|a The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.
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allfields	10.1183/23120541.00381-2020 doi (DE-627)DOAJ050193961 (DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7 DE-627 ger DE-627 rakwb eng Berta Saez-Gimenez verfasserin aut Near-normal aerobic capacity in long-term survivors after lung transplantation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Medicine R Miriam Barrecheguren verfasserin aut Maria Antònia Ramon verfasserin aut Alba Gomez-Garrido verfasserin aut Carlos Bravo verfasserin aut Víctor Monforte verfasserin aut Manuel López-Meseguer verfasserin aut Cristina Berastegui verfasserin aut Eva Revilla verfasserin aut Christian Romero verfasserin aut Rosalía Laporta verfasserin aut Sonia Fernández-Rozas verfasserin aut Javier Redel-Montero verfasserin aut Amparo Solé verfasserin aut Mercedes de la Torre verfasserin aut Luis Puente verfasserin aut Antonio Roman verfasserin aut Susana Gómez-Ollés verfasserin aut Iñigo Ojanguren verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00381-2020 kostenfrei https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 kostenfrei http://openres.ersjournals.com/content/7/1/00381-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
spelling	10.1183/23120541.00381-2020 doi (DE-627)DOAJ050193961 (DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7 DE-627 ger DE-627 rakwb eng Berta Saez-Gimenez verfasserin aut Near-normal aerobic capacity in long-term survivors after lung transplantation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Medicine R Miriam Barrecheguren verfasserin aut Maria Antònia Ramon verfasserin aut Alba Gomez-Garrido verfasserin aut Carlos Bravo verfasserin aut Víctor Monforte verfasserin aut Manuel López-Meseguer verfasserin aut Cristina Berastegui verfasserin aut Eva Revilla verfasserin aut Christian Romero verfasserin aut Rosalía Laporta verfasserin aut Sonia Fernández-Rozas verfasserin aut Javier Redel-Montero verfasserin aut Amparo Solé verfasserin aut Mercedes de la Torre verfasserin aut Luis Puente verfasserin aut Antonio Roman verfasserin aut Susana Gómez-Ollés verfasserin aut Iñigo Ojanguren verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00381-2020 kostenfrei https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 kostenfrei http://openres.ersjournals.com/content/7/1/00381-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfields_unstemmed	10.1183/23120541.00381-2020 doi (DE-627)DOAJ050193961 (DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7 DE-627 ger DE-627 rakwb eng Berta Saez-Gimenez verfasserin aut Near-normal aerobic capacity in long-term survivors after lung transplantation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Medicine R Miriam Barrecheguren verfasserin aut Maria Antònia Ramon verfasserin aut Alba Gomez-Garrido verfasserin aut Carlos Bravo verfasserin aut Víctor Monforte verfasserin aut Manuel López-Meseguer verfasserin aut Cristina Berastegui verfasserin aut Eva Revilla verfasserin aut Christian Romero verfasserin aut Rosalía Laporta verfasserin aut Sonia Fernández-Rozas verfasserin aut Javier Redel-Montero verfasserin aut Amparo Solé verfasserin aut Mercedes de la Torre verfasserin aut Luis Puente verfasserin aut Antonio Roman verfasserin aut Susana Gómez-Ollés verfasserin aut Iñigo Ojanguren verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00381-2020 kostenfrei https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 kostenfrei http://openres.ersjournals.com/content/7/1/00381-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfieldsGer	10.1183/23120541.00381-2020 doi (DE-627)DOAJ050193961 (DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7 DE-627 ger DE-627 rakwb eng Berta Saez-Gimenez verfasserin aut Near-normal aerobic capacity in long-term survivors after lung transplantation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Medicine R Miriam Barrecheguren verfasserin aut Maria Antònia Ramon verfasserin aut Alba Gomez-Garrido verfasserin aut Carlos Bravo verfasserin aut Víctor Monforte verfasserin aut Manuel López-Meseguer verfasserin aut Cristina Berastegui verfasserin aut Eva Revilla verfasserin aut Christian Romero verfasserin aut Rosalía Laporta verfasserin aut Sonia Fernández-Rozas verfasserin aut Javier Redel-Montero verfasserin aut Amparo Solé verfasserin aut Mercedes de la Torre verfasserin aut Luis Puente verfasserin aut Antonio Roman verfasserin aut Susana Gómez-Ollés verfasserin aut Iñigo Ojanguren verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00381-2020 kostenfrei https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 kostenfrei http://openres.ersjournals.com/content/7/1/00381-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfieldsSound	10.1183/23120541.00381-2020 doi (DE-627)DOAJ050193961 (DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7 DE-627 ger DE-627 rakwb eng Berta Saez-Gimenez verfasserin aut Near-normal aerobic capacity in long-term survivors after lung transplantation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD. Medicine R Miriam Barrecheguren verfasserin aut Maria Antònia Ramon verfasserin aut Alba Gomez-Garrido verfasserin aut Carlos Bravo verfasserin aut Víctor Monforte verfasserin aut Manuel López-Meseguer verfasserin aut Cristina Berastegui verfasserin aut Eva Revilla verfasserin aut Christian Romero verfasserin aut Rosalía Laporta verfasserin aut Sonia Fernández-Rozas verfasserin aut Javier Redel-Montero verfasserin aut Amparo Solé verfasserin aut Mercedes de la Torre verfasserin aut Luis Puente verfasserin aut Antonio Roman verfasserin aut Susana Gómez-Ollés verfasserin aut Iñigo Ojanguren verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00381-2020 kostenfrei https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 kostenfrei http://openres.ersjournals.com/content/7/1/00381-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
language	English
source	In ERJ Open Research 7(2021), 1 volume:7 year:2021 number:1
sourceStr	In ERJ Open Research 7(2021), 1 volume:7 year:2021 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R
isfreeaccess_bool	true
container_title	ERJ Open Research
authorswithroles_txt_mv	Berta Saez-Gimenez @@aut@@ Miriam Barrecheguren @@aut@@ Maria Antònia Ramon @@aut@@ Alba Gomez-Garrido @@aut@@ Carlos Bravo @@aut@@ Víctor Monforte @@aut@@ Manuel López-Meseguer @@aut@@ Cristina Berastegui @@aut@@ Eva Revilla @@aut@@ Christian Romero @@aut@@ Rosalía Laporta @@aut@@ Sonia Fernández-Rozas @@aut@@ Javier Redel-Montero @@aut@@ Amparo Solé @@aut@@ Mercedes de la Torre @@aut@@ Luis Puente @@aut@@ Antonio Roman @@aut@@ Susana Gómez-Ollés @@aut@@ Iñigo Ojanguren @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	830141227
id	DOAJ050193961
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ050193961</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308151456.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1183/23120541.00381-2020</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ050193961</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb4aecb4441ab43d5a40180c069c798c7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Berta Saez-Gimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Near-normal aerobic capacity in long-term survivors after lung transplantation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. 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author	Berta Saez-Gimenez
spellingShingle	Berta Saez-Gimenez misc Medicine misc R Near-normal aerobic capacity in long-term survivors after lung transplantation
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topic_title	Near-normal aerobic capacity in long-term survivors after lung transplantation
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title	Near-normal aerobic capacity in long-term survivors after lung transplantation
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title_full	Near-normal aerobic capacity in long-term survivors after lung transplantation
author_sort	Berta Saez-Gimenez
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author_browse	Berta Saez-Gimenez Miriam Barrecheguren Maria Antònia Ramon Alba Gomez-Garrido Carlos Bravo Víctor Monforte Manuel López-Meseguer Cristina Berastegui Eva Revilla Christian Romero Rosalía Laporta Sonia Fernández-Rozas Javier Redel-Montero Amparo Solé Mercedes de la Torre Luis Puente Antonio Roman Susana Gómez-Ollés Iñigo Ojanguren
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title_sort	near-normal aerobic capacity in long-term survivors after lung transplantation
title_auth	Near-normal aerobic capacity in long-term survivors after lung transplantation
abstract	The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.
abstractGer	The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.
abstract_unstemmed	The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.
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title_short	Near-normal aerobic capacity in long-term survivors after lung transplantation
url	https://doi.org/10.1183/23120541.00381-2020 https://doaj.org/article/b4aecb4441ab43d5a40180c069c798c7 http://openres.ersjournals.com/content/7/1/00381-2020.full https://doaj.org/toc/2312-0541
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author2	Miriam Barrecheguren Maria Antònia Ramon Alba Gomez-Garrido Carlos Bravo Víctor Monforte Manuel López-Meseguer Cristina Berastegui Eva Revilla Christian Romero Rosalía Laporta Sonia Fernández-Rozas Javier Redel-Montero Amparo Solé Mercedes de la Torre Luis Puente Antonio Roman Susana Gómez-Ollés Iñigo Ojanguren
author2Str	Miriam Barrecheguren Maria Antònia Ramon Alba Gomez-Garrido Carlos Bravo Víctor Monforte Manuel López-Meseguer Cristina Berastegui Eva Revilla Christian Romero Rosalía Laporta Sonia Fernández-Rozas Javier Redel-Montero Amparo Solé Mercedes de la Torre Luis Puente Antonio Roman Susana Gómez-Ollés Iñigo Ojanguren
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up_date	2024-07-03T13:32:06.338Z
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