Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia

<p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder....
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Autor*in:	Pimm Jonathan [verfasserIn] Quested Digby [verfasserIn] Thirumalai Srinivasa [verfasserIn] Lawrence Jacob [verfasserIn] Choudhury Khalid [verfasserIn] Puri Vinay [verfasserIn] McQuillin Andrew [verfasserIn] Datta Susmita R [verfasserIn] Bass Nicholas J [verfasserIn] Curtis David [verfasserIn] Gurling Hugh MD [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: Behavioral and Brain Functions - BMC, 2005, 5(2009), 1, p 28
Übergeordnetes Werk:	volume:5 ; year:2009 ; number:1, p 28

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1744-9081-5-28

Katalog-ID:	DOAJ050362232

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allfields	10.1186/1744-9081-5-28 doi (DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6 DE-627 ger DE-627 rakwb eng RC346-429 Pimm Jonathan verfasserin aut Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p< Neurology. Diseases of the nervous system Quested Digby verfasserin aut Thirumalai Srinivasa verfasserin aut Lawrence Jacob verfasserin aut Choudhury Khalid verfasserin aut Puri Vinay verfasserin aut McQuillin Andrew verfasserin aut Datta Susmita R verfasserin aut Bass Nicholas J verfasserin aut Curtis David verfasserin aut Gurling Hugh MD verfasserin aut In Behavioral and Brain Functions BMC, 2005 5(2009), 1, p 28 (DE-627)484836994 (DE-600)2185773-8 17449081 nnns volume:5 year:2009 number:1, p 28 https://doi.org/10.1186/1744-9081-5-28 kostenfrei https://doaj.org/article/f72e6a4f54d343aa91618c9c158460a6 kostenfrei http://www.behavioralandbrainfunctions.com/content/5/1/28 kostenfrei https://doaj.org/toc/1744-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1, p 28
spelling	10.1186/1744-9081-5-28 doi (DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6 DE-627 ger DE-627 rakwb eng RC346-429 Pimm Jonathan verfasserin aut Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p< Neurology. Diseases of the nervous system Quested Digby verfasserin aut Thirumalai Srinivasa verfasserin aut Lawrence Jacob verfasserin aut Choudhury Khalid verfasserin aut Puri Vinay verfasserin aut McQuillin Andrew verfasserin aut Datta Susmita R verfasserin aut Bass Nicholas J verfasserin aut Curtis David verfasserin aut Gurling Hugh MD verfasserin aut In Behavioral and Brain Functions BMC, 2005 5(2009), 1, p 28 (DE-627)484836994 (DE-600)2185773-8 17449081 nnns volume:5 year:2009 number:1, p 28 https://doi.org/10.1186/1744-9081-5-28 kostenfrei https://doaj.org/article/f72e6a4f54d343aa91618c9c158460a6 kostenfrei http://www.behavioralandbrainfunctions.com/content/5/1/28 kostenfrei https://doaj.org/toc/1744-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1, p 28
allfields_unstemmed	10.1186/1744-9081-5-28 doi (DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6 DE-627 ger DE-627 rakwb eng RC346-429 Pimm Jonathan verfasserin aut Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p< Neurology. Diseases of the nervous system Quested Digby verfasserin aut Thirumalai Srinivasa verfasserin aut Lawrence Jacob verfasserin aut Choudhury Khalid verfasserin aut Puri Vinay verfasserin aut McQuillin Andrew verfasserin aut Datta Susmita R verfasserin aut Bass Nicholas J verfasserin aut Curtis David verfasserin aut Gurling Hugh MD verfasserin aut In Behavioral and Brain Functions BMC, 2005 5(2009), 1, p 28 (DE-627)484836994 (DE-600)2185773-8 17449081 nnns volume:5 year:2009 number:1, p 28 https://doi.org/10.1186/1744-9081-5-28 kostenfrei https://doaj.org/article/f72e6a4f54d343aa91618c9c158460a6 kostenfrei http://www.behavioralandbrainfunctions.com/content/5/1/28 kostenfrei https://doaj.org/toc/1744-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1, p 28
allfieldsGer	10.1186/1744-9081-5-28 doi (DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6 DE-627 ger DE-627 rakwb eng RC346-429 Pimm Jonathan verfasserin aut Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p< Neurology. Diseases of the nervous system Quested Digby verfasserin aut Thirumalai Srinivasa verfasserin aut Lawrence Jacob verfasserin aut Choudhury Khalid verfasserin aut Puri Vinay verfasserin aut McQuillin Andrew verfasserin aut Datta Susmita R verfasserin aut Bass Nicholas J verfasserin aut Curtis David verfasserin aut Gurling Hugh MD verfasserin aut In Behavioral and Brain Functions BMC, 2005 5(2009), 1, p 28 (DE-627)484836994 (DE-600)2185773-8 17449081 nnns volume:5 year:2009 number:1, p 28 https://doi.org/10.1186/1744-9081-5-28 kostenfrei https://doaj.org/article/f72e6a4f54d343aa91618c9c158460a6 kostenfrei http://www.behavioralandbrainfunctions.com/content/5/1/28 kostenfrei https://doaj.org/toc/1744-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1, p 28
allfieldsSound	10.1186/1744-9081-5-28 doi (DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6 DE-627 ger DE-627 rakwb eng RC346-429 Pimm Jonathan verfasserin aut Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p< Neurology. Diseases of the nervous system Quested Digby verfasserin aut Thirumalai Srinivasa verfasserin aut Lawrence Jacob verfasserin aut Choudhury Khalid verfasserin aut Puri Vinay verfasserin aut McQuillin Andrew verfasserin aut Datta Susmita R verfasserin aut Bass Nicholas J verfasserin aut Curtis David verfasserin aut Gurling Hugh MD verfasserin aut In Behavioral and Brain Functions BMC, 2005 5(2009), 1, p 28 (DE-627)484836994 (DE-600)2185773-8 17449081 nnns volume:5 year:2009 number:1, p 28 https://doi.org/10.1186/1744-9081-5-28 kostenfrei https://doaj.org/article/f72e6a4f54d343aa91618c9c158460a6 kostenfrei http://www.behavioralandbrainfunctions.com/content/5/1/28 kostenfrei https://doaj.org/toc/1744-9081 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1, p 28
language	English
source	In Behavioral and Brain Functions 5(2009), 1, p 28 volume:5 year:2009 number:1, p 28
sourceStr	In Behavioral and Brain Functions 5(2009), 1, p 28 volume:5 year:2009 number:1, p 28
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Behavioral and Brain Functions
authorswithroles_txt_mv	Pimm Jonathan @@aut@@ Quested Digby @@aut@@ Thirumalai Srinivasa @@aut@@ Lawrence Jacob @@aut@@ Choudhury Khalid @@aut@@ Puri Vinay @@aut@@ McQuillin Andrew @@aut@@ Datta Susmita R @@aut@@ Bass Nicholas J @@aut@@ Curtis David @@aut@@ Gurling Hugh MD @@aut@@
publishDateDaySort_date	2009-01-01T00:00:00Z
hierarchy_top_id	484836994
id	DOAJ050362232
language_de	englisch
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callnumber-first	R - Medicine
author	Pimm Jonathan
spellingShingle	Pimm Jonathan misc RC346-429 misc Neurology. Diseases of the nervous system Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
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topic_title	RC346-429 Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
topic	misc RC346-429 misc Neurology. Diseases of the nervous system
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title	Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
ctrlnum	(DE-627)DOAJ050362232 (DE-599)DOAJf72e6a4f54d343aa91618c9c158460a6
title_full	Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
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journal	Behavioral and Brain Functions
journalStr	Behavioral and Brain Functions
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author_browse	Pimm Jonathan Quested Digby Thirumalai Srinivasa Lawrence Jacob Choudhury Khalid Puri Vinay McQuillin Andrew Datta Susmita R Bass Nicholas J Curtis David Gurling Hugh MD
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title_sort	evidence for the association of the daoa (g72) gene with schizophrenia and bipolar disorder but not for the association of the dao gene with schizophrenia
callnumber	RC346-429
title_auth	Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
abstract	<p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.</p< <p<Methods</p< <p<We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.</p< <p<Results</p< <p<Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ<sup<2 </sup<= 5.824 p = 0.016) and bipolar disorder (χ<sup<2 </sup<= 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ<sup<2 </sup<= 3.675 p = 0.055) and rs1421292 (M24; χ<sup<2 </sup<= 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.</p< <p<Conclusion</p< <p<Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.</p<
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title_short	Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
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score	7.3980417

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Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia

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