Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage
Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disrupt...
Ausführliche Beschreibung
Autor*in: |
Jason J Chang [verfasserIn] Rocco Armonda [verfasserIn] Nitin Goyal [verfasserIn] Adam S Arthur [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Schlagwörter: |
intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema |
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Übergeordnetes Werk: |
In: Neural Regeneration Research - Wolters Kluwer Medknow Publications, 2014, 14(2019), 7, Seite 1116-1121 |
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Übergeordnetes Werk: |
volume:14 ; year:2019 ; number:7 ; pages:1116-1121 |
Links: |
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DOI / URN: |
10.4103/1673-5374.251189 |
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Katalog-ID: |
DOAJ050404938 |
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520 | |a Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. | ||
650 | 4 | |a intracerebral hemorrhage; stroke | |
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10.4103/1673-5374.251189 doi (DE-627)DOAJ050404938 (DE-599)DOAJdb861e0fb3aa4fa69428fed18a0fbc7c DE-627 ger DE-627 rakwb eng RC346-429 Jason J Chang verfasserin aut Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema Neurology. Diseases of the nervous system Rocco Armonda verfasserin aut Nitin Goyal verfasserin aut Adam S Arthur verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 14(2019), 7, Seite 1116-1121 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:14 year:2019 number:7 pages:1116-1121 https://doi.org/10.4103/1673-5374.251189 kostenfrei https://doaj.org/article/db861e0fb3aa4fa69428fed18a0fbc7c kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=7;spage=1116;epage=1121;aulast=Chang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 7 1116-1121 |
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10.4103/1673-5374.251189 doi (DE-627)DOAJ050404938 (DE-599)DOAJdb861e0fb3aa4fa69428fed18a0fbc7c DE-627 ger DE-627 rakwb eng RC346-429 Jason J Chang verfasserin aut Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema Neurology. Diseases of the nervous system Rocco Armonda verfasserin aut Nitin Goyal verfasserin aut Adam S Arthur verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 14(2019), 7, Seite 1116-1121 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:14 year:2019 number:7 pages:1116-1121 https://doi.org/10.4103/1673-5374.251189 kostenfrei https://doaj.org/article/db861e0fb3aa4fa69428fed18a0fbc7c kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=7;spage=1116;epage=1121;aulast=Chang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 7 1116-1121 |
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10.4103/1673-5374.251189 doi (DE-627)DOAJ050404938 (DE-599)DOAJdb861e0fb3aa4fa69428fed18a0fbc7c DE-627 ger DE-627 rakwb eng RC346-429 Jason J Chang verfasserin aut Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema Neurology. Diseases of the nervous system Rocco Armonda verfasserin aut Nitin Goyal verfasserin aut Adam S Arthur verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 14(2019), 7, Seite 1116-1121 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:14 year:2019 number:7 pages:1116-1121 https://doi.org/10.4103/1673-5374.251189 kostenfrei https://doaj.org/article/db861e0fb3aa4fa69428fed18a0fbc7c kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=7;spage=1116;epage=1121;aulast=Chang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 7 1116-1121 |
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10.4103/1673-5374.251189 doi (DE-627)DOAJ050404938 (DE-599)DOAJdb861e0fb3aa4fa69428fed18a0fbc7c DE-627 ger DE-627 rakwb eng RC346-429 Jason J Chang verfasserin aut Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema Neurology. Diseases of the nervous system Rocco Armonda verfasserin aut Nitin Goyal verfasserin aut Adam S Arthur verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 14(2019), 7, Seite 1116-1121 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:14 year:2019 number:7 pages:1116-1121 https://doi.org/10.4103/1673-5374.251189 kostenfrei https://doaj.org/article/db861e0fb3aa4fa69428fed18a0fbc7c kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=7;spage=1116;epage=1121;aulast=Chang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 7 1116-1121 |
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10.4103/1673-5374.251189 doi (DE-627)DOAJ050404938 (DE-599)DOAJdb861e0fb3aa4fa69428fed18a0fbc7c DE-627 ger DE-627 rakwb eng RC346-429 Jason J Chang verfasserin aut Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. intracerebral hemorrhage; stroke magnesium; vasodilation; hemostasis; blood-brain barrier; perihematomal edema Neurology. Diseases of the nervous system Rocco Armonda verfasserin aut Nitin Goyal verfasserin aut Adam S Arthur verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 14(2019), 7, Seite 1116-1121 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:14 year:2019 number:7 pages:1116-1121 https://doi.org/10.4103/1673-5374.251189 kostenfrei https://doaj.org/article/db861e0fb3aa4fa69428fed18a0fbc7c kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=7;spage=1116;epage=1121;aulast=Chang kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 7 1116-1121 |
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Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. |
abstractGer |
Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. |
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Intracerebral hemorrhage (ICH) remains the second-most common form of stroke with high morbidity and mortality. ICH can be divided into two pathophysiological stages: an acute primary phase, including hematoma volume expansion, and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion. To date, all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control, surgical evacuation, and hemostasis. However, none of these trials has resulted in improved clinical outcomes. Magnesium is a ubiquitous element that also plays roles in vasodilation, hemostasis, and blood-brain barrier preservation. Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms. Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume, hematoma expansion, and clinical outcome in patients with ICH. These associations, coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH, suggest that magnesium may be a viable target of study in future ICH studies. |
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