ABO blood types and sepsis mortality

Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the...
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Autor*in:	Theis S. Itenov [verfasserIn] Daniel I. Sessler [verfasserIn] Ashish K. Khanna [verfasserIn] Sisse R. Ostrowski [verfasserIn] Pär I. Johansson [verfasserIn] Christian Erikstrup [verfasserIn] Ole B. Pedersen [verfasserIn] Sofie L. Rygård [verfasserIn] Lars B. Holst [verfasserIn] Morten H. Bestle [verfasserIn] Lars Hein [verfasserIn] Anne Lindhardt [verfasserIn] Hami Tousi [verfasserIn] Mads H. Andersen [verfasserIn] Thomas Mohr [verfasserIn] Jens D. Lundgren [verfasserIn] Jens-Ulrik Jensen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care

Übergeordnetes Werk:	In: Annals of Intensive Care - SpringerOpen, 2012, 11(2021), 1, Seite 9
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13613-021-00844-2

Katalog-ID:	DOAJ050463888

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520			\|a Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.
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Indexfelder

author_variant	t s i tsi d i s dis a k k akk s r o sro p i j pij c e ce o b p obp s l r slr l b h lbh m h b mhb l h lh a l al h t ht m h a mha t m tm j d l jdl j u j juj
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allfields	10.1186/s13613-021-00844-2 doi (DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239 DE-627 ger DE-627 rakwb eng RC86-88.9 Theis S. Itenov verfasserin aut ABO blood types and sepsis mortality 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid Daniel I. Sessler verfasserin aut Ashish K. Khanna verfasserin aut Sisse R. Ostrowski verfasserin aut Pär I. Johansson verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Sofie L. Rygård verfasserin aut Lars B. Holst verfasserin aut Morten H. Bestle verfasserin aut Lars Hein verfasserin aut Anne Lindhardt verfasserin aut Hami Tousi verfasserin aut Mads H. Andersen verfasserin aut Thomas Mohr verfasserin aut Jens D. Lundgren verfasserin aut Jens-Ulrik Jensen verfasserin aut In Annals of Intensive Care SpringerOpen, 2012 11(2021), 1, Seite 9 (DE-627)664260918 (DE-600)2617094-2 21105820 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/article/6496cd451d274d34837948a1c53d4239 kostenfrei https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/toc/2110-5820 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
spelling	10.1186/s13613-021-00844-2 doi (DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239 DE-627 ger DE-627 rakwb eng RC86-88.9 Theis S. Itenov verfasserin aut ABO blood types and sepsis mortality 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid Daniel I. Sessler verfasserin aut Ashish K. Khanna verfasserin aut Sisse R. Ostrowski verfasserin aut Pär I. Johansson verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Sofie L. Rygård verfasserin aut Lars B. Holst verfasserin aut Morten H. Bestle verfasserin aut Lars Hein verfasserin aut Anne Lindhardt verfasserin aut Hami Tousi verfasserin aut Mads H. Andersen verfasserin aut Thomas Mohr verfasserin aut Jens D. Lundgren verfasserin aut Jens-Ulrik Jensen verfasserin aut In Annals of Intensive Care SpringerOpen, 2012 11(2021), 1, Seite 9 (DE-627)664260918 (DE-600)2617094-2 21105820 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/article/6496cd451d274d34837948a1c53d4239 kostenfrei https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/toc/2110-5820 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfields_unstemmed	10.1186/s13613-021-00844-2 doi (DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239 DE-627 ger DE-627 rakwb eng RC86-88.9 Theis S. Itenov verfasserin aut ABO blood types and sepsis mortality 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid Daniel I. Sessler verfasserin aut Ashish K. Khanna verfasserin aut Sisse R. Ostrowski verfasserin aut Pär I. Johansson verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Sofie L. Rygård verfasserin aut Lars B. Holst verfasserin aut Morten H. Bestle verfasserin aut Lars Hein verfasserin aut Anne Lindhardt verfasserin aut Hami Tousi verfasserin aut Mads H. Andersen verfasserin aut Thomas Mohr verfasserin aut Jens D. Lundgren verfasserin aut Jens-Ulrik Jensen verfasserin aut In Annals of Intensive Care SpringerOpen, 2012 11(2021), 1, Seite 9 (DE-627)664260918 (DE-600)2617094-2 21105820 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/article/6496cd451d274d34837948a1c53d4239 kostenfrei https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/toc/2110-5820 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfieldsGer	10.1186/s13613-021-00844-2 doi (DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239 DE-627 ger DE-627 rakwb eng RC86-88.9 Theis S. Itenov verfasserin aut ABO blood types and sepsis mortality 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid Daniel I. Sessler verfasserin aut Ashish K. Khanna verfasserin aut Sisse R. Ostrowski verfasserin aut Pär I. Johansson verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Sofie L. Rygård verfasserin aut Lars B. Holst verfasserin aut Morten H. Bestle verfasserin aut Lars Hein verfasserin aut Anne Lindhardt verfasserin aut Hami Tousi verfasserin aut Mads H. Andersen verfasserin aut Thomas Mohr verfasserin aut Jens D. Lundgren verfasserin aut Jens-Ulrik Jensen verfasserin aut In Annals of Intensive Care SpringerOpen, 2012 11(2021), 1, Seite 9 (DE-627)664260918 (DE-600)2617094-2 21105820 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/article/6496cd451d274d34837948a1c53d4239 kostenfrei https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/toc/2110-5820 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfieldsSound	10.1186/s13613-021-00844-2 doi (DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239 DE-627 ger DE-627 rakwb eng RC86-88.9 Theis S. Itenov verfasserin aut ABO blood types and sepsis mortality 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid Daniel I. Sessler verfasserin aut Ashish K. Khanna verfasserin aut Sisse R. Ostrowski verfasserin aut Pär I. Johansson verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Sofie L. Rygård verfasserin aut Lars B. Holst verfasserin aut Morten H. Bestle verfasserin aut Lars Hein verfasserin aut Anne Lindhardt verfasserin aut Hami Tousi verfasserin aut Mads H. Andersen verfasserin aut Thomas Mohr verfasserin aut Jens D. Lundgren verfasserin aut Jens-Ulrik Jensen verfasserin aut In Annals of Intensive Care SpringerOpen, 2012 11(2021), 1, Seite 9 (DE-627)664260918 (DE-600)2617094-2 21105820 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/article/6496cd451d274d34837948a1c53d4239 kostenfrei https://doi.org/10.1186/s13613-021-00844-2 kostenfrei https://doaj.org/toc/2110-5820 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
language	English
source	In Annals of Intensive Care 11(2021), 1, Seite 9 volume:11 year:2021 number:1 pages:9
sourceStr	In Annals of Intensive Care 11(2021), 1, Seite 9 volume:11 year:2021 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care Medical emergencies. Critical care. Intensive care. First aid
isfreeaccess_bool	true
container_title	Annals of Intensive Care
authorswithroles_txt_mv	Theis S. Itenov @@aut@@ Daniel I. Sessler @@aut@@ Ashish K. Khanna @@aut@@ Sisse R. Ostrowski @@aut@@ Pär I. Johansson @@aut@@ Christian Erikstrup @@aut@@ Ole B. Pedersen @@aut@@ Sofie L. Rygård @@aut@@ Lars B. Holst @@aut@@ Morten H. Bestle @@aut@@ Lars Hein @@aut@@ Anne Lindhardt @@aut@@ Hami Tousi @@aut@@ Mads H. Andersen @@aut@@ Thomas Mohr @@aut@@ Jens D. Lundgren @@aut@@ Jens-Ulrik Jensen @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	664260918
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language_de	englisch
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callnumber-first	R - Medicine
author	Theis S. Itenov
spellingShingle	Theis S. Itenov misc RC86-88.9 misc Anaesthesia misc Blood type misc Mortality misc Sepsis misc Septic shock misc Intensive care misc Medical emergencies. Critical care. Intensive care. First aid ABO blood types and sepsis mortality
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topic_title	RC86-88.9 ABO blood types and sepsis mortality Anaesthesia Blood type Mortality Sepsis Septic shock Intensive care
topic	misc RC86-88.9 misc Anaesthesia misc Blood type misc Mortality misc Sepsis misc Septic shock misc Intensive care misc Medical emergencies. Critical care. Intensive care. First aid
topic_unstemmed	misc RC86-88.9 misc Anaesthesia misc Blood type misc Mortality misc Sepsis misc Septic shock misc Intensive care misc Medical emergencies. Critical care. Intensive care. First aid
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title	ABO blood types and sepsis mortality
ctrlnum	(DE-627)DOAJ050463888 (DE-599)DOAJ6496cd451d274d34837948a1c53d4239
title_full	ABO blood types and sepsis mortality
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author_browse	Theis S. Itenov Daniel I. Sessler Ashish K. Khanna Sisse R. Ostrowski Pär I. Johansson Christian Erikstrup Ole B. Pedersen Sofie L. Rygård Lars B. Holst Morten H. Bestle Lars Hein Anne Lindhardt Hami Tousi Mads H. Andersen Thomas Mohr Jens D. Lundgren Jens-Ulrik Jensen
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doi_str_mv	10.1186/s13613-021-00844-2
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title_sort	abo blood types and sepsis mortality
callnumber	RC86-88.9
title_auth	ABO blood types and sepsis mortality
abstract	Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.
abstractGer	Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.
abstract_unstemmed	Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.
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title_short	ABO blood types and sepsis mortality
url	https://doi.org/10.1186/s13613-021-00844-2 https://doaj.org/article/6496cd451d274d34837948a1c53d4239 https://doaj.org/toc/2110-5820
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author2	Daniel I. Sessler Ashish K. Khanna Sisse R. Ostrowski Pär I. Johansson Christian Erikstrup Ole B. Pedersen Sofie L. Rygård Lars B. Holst Morten H. Bestle Lars Hein Anne Lindhardt Hami Tousi Mads H. Andersen Thomas Mohr Jens D. Lundgren Jens-Ulrik Jensen
author2Str	Daniel I. Sessler Ashish K. Khanna Sisse R. Ostrowski Pär I. Johansson Christian Erikstrup Ole B. Pedersen Sofie L. Rygård Lars B. Holst Morten H. Bestle Lars Hein Anne Lindhardt Hami Tousi Mads H. Andersen Thomas Mohr Jens D. Lundgren Jens-Ulrik Jensen
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up_date	2024-07-03T15:00:02.450Z
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ABO blood types and sepsis mortality

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Zugang & Verfügbarkeit

Vorhandene Bände

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