Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate

Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many s...
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Gespeichert in:

Autor*in:	Ava Behrouzi [verfasserIn] Reza Arabi Mianroodi [verfasserIn] Parviz Afrough [verfasserIn] Ahmad Ayadi [verfasserIn] Amirarsalan Serajian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine

Übergeordnetes Werk:	In: Iranian Journal of Microbiology - Tehran University of Medical Sciences, 2020, 12(2020), 5
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.18502/ijm.v12i5.4602

Katalog-ID:	DOAJ050464701

Internformat


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041			\|a eng
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100	0		\|a Ava Behrouzi \|e verfasserin \|4 aut
245	1	0	\|a Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections.
650		4	\|a Non typeable Haemophilus influenza;
650		4	\|a Outer membrane vesicle;
650		4	\|a Vaccine
653		0	\|a Microbiology
700	0		\|a Reza Arabi Mianroodi \|e verfasserin \|4 aut
700	0		\|a Parviz Afrough \|e verfasserin \|4 aut
700	0		\|a Ahmad Ayadi \|e verfasserin \|4 aut
700	0		\|a Amirarsalan Serajian \|e verfasserin \|4 aut
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912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2020 \|e 5

Indexfelder

author_variant	a b ab r a m ram p a pa a a aa a s as
matchkey_str	article:20084447:2020----::vlainfmuooiarsossgisotrebaeeilsmonnyebeampiuifunaui
hierarchy_sort_str	2020
callnumber-subject-code	QR
publishDate	2020
allfields	10.18502/ijm.v12i5.4602 doi (DE-627)DOAJ050464701 (DE-599)DOAJ05d7fe3888b149b8b449b777643588d5 DE-627 ger DE-627 rakwb eng QR1-502 Ava Behrouzi verfasserin aut Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections. Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology Reza Arabi Mianroodi verfasserin aut Parviz Afrough verfasserin aut Ahmad Ayadi verfasserin aut Amirarsalan Serajian verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 12(2020), 5 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:12 year:2020 number:5 https://doi.org/10.18502/ijm.v12i5.4602 kostenfrei https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 5
spelling	10.18502/ijm.v12i5.4602 doi (DE-627)DOAJ050464701 (DE-599)DOAJ05d7fe3888b149b8b449b777643588d5 DE-627 ger DE-627 rakwb eng QR1-502 Ava Behrouzi verfasserin aut Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections. Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology Reza Arabi Mianroodi verfasserin aut Parviz Afrough verfasserin aut Ahmad Ayadi verfasserin aut Amirarsalan Serajian verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 12(2020), 5 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:12 year:2020 number:5 https://doi.org/10.18502/ijm.v12i5.4602 kostenfrei https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 5
allfields_unstemmed	10.18502/ijm.v12i5.4602 doi (DE-627)DOAJ050464701 (DE-599)DOAJ05d7fe3888b149b8b449b777643588d5 DE-627 ger DE-627 rakwb eng QR1-502 Ava Behrouzi verfasserin aut Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections. Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology Reza Arabi Mianroodi verfasserin aut Parviz Afrough verfasserin aut Ahmad Ayadi verfasserin aut Amirarsalan Serajian verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 12(2020), 5 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:12 year:2020 number:5 https://doi.org/10.18502/ijm.v12i5.4602 kostenfrei https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 5
allfieldsGer	10.18502/ijm.v12i5.4602 doi (DE-627)DOAJ050464701 (DE-599)DOAJ05d7fe3888b149b8b449b777643588d5 DE-627 ger DE-627 rakwb eng QR1-502 Ava Behrouzi verfasserin aut Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections. Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology Reza Arabi Mianroodi verfasserin aut Parviz Afrough verfasserin aut Ahmad Ayadi verfasserin aut Amirarsalan Serajian verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 12(2020), 5 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:12 year:2020 number:5 https://doi.org/10.18502/ijm.v12i5.4602 kostenfrei https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 5
allfieldsSound	10.18502/ijm.v12i5.4602 doi (DE-627)DOAJ050464701 (DE-599)DOAJ05d7fe3888b149b8b449b777643588d5 DE-627 ger DE-627 rakwb eng QR1-502 Ava Behrouzi verfasserin aut Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections. Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology Reza Arabi Mianroodi verfasserin aut Parviz Afrough verfasserin aut Ahmad Ayadi verfasserin aut Amirarsalan Serajian verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 12(2020), 5 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:12 year:2020 number:5 https://doi.org/10.18502/ijm.v12i5.4602 kostenfrei https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 5
language	English
source	In Iranian Journal of Microbiology 12(2020), 5 volume:12 year:2020 number:5
sourceStr	In Iranian Journal of Microbiology 12(2020), 5 volume:12 year:2020 number:5
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Non typeable Haemophilus influenza; Outer membrane vesicle; Vaccine Microbiology
isfreeaccess_bool	true
container_title	Iranian Journal of Microbiology
authorswithroles_txt_mv	Ava Behrouzi @@aut@@ Reza Arabi Mianroodi @@aut@@ Parviz Afrough @@aut@@ Ahmad Ayadi @@aut@@ Amirarsalan Serajian @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	688077226
id	DOAJ050464701
language_de	englisch
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callnumber-first	Q - Science
author	Ava Behrouzi
spellingShingle	Ava Behrouzi misc QR1-502 misc Non typeable Haemophilus influenza; misc Outer membrane vesicle; misc Vaccine misc Microbiology Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
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topic_title	QR1-502 Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate Non typeable Haemophilus influenza Outer membrane vesicle Vaccine
topic	misc QR1-502 misc Non typeable Haemophilus influenza; misc Outer membrane vesicle; misc Vaccine misc Microbiology
topic_unstemmed	misc QR1-502 misc Non typeable Haemophilus influenza; misc Outer membrane vesicle; misc Vaccine misc Microbiology
topic_browse	misc QR1-502 misc Non typeable Haemophilus influenza; misc Outer membrane vesicle; misc Vaccine misc Microbiology
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title	Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
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title_full	Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
author_sort	Ava Behrouzi
journal	Iranian Journal of Microbiology
journalStr	Iranian Journal of Microbiology
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author_browse	Ava Behrouzi Reza Arabi Mianroodi Parviz Afrough Ahmad Ayadi Amirarsalan Serajian
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doi_str_mv	10.18502/ijm.v12i5.4602
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title_sort	evaluation of immunological responses against outer membrane vesicles (omv) of nontypeable haemophilus influenzae using mpla-cpg adjuvant as a vaccine candidate
callnumber	QR1-502
title_auth	Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
abstract	Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections.
abstractGer	Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections.
abstract_unstemmed	Background and Objectives: Nontypeable Haemophilus influenzae (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. Materials and Methods: In this study, standard OMV Haemophilus (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. Conclusion: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections.
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container_issue	5
title_short	Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate
url	https://doi.org/10.18502/ijm.v12i5.4602 https://doaj.org/article/05d7fe3888b149b8b449b777643588d5 https://ijm.tums.ac.ir/index.php/ijm/article/view/2049 https://doaj.org/toc/2008-3289 https://doaj.org/toc/2008-4447
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author2	Reza Arabi Mianroodi Parviz Afrough Ahmad Ayadi Amirarsalan Serajian
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up_date	2024-07-03T15:00:18.401Z
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