Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells

The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2...
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Gespeichert in:

Autor*in:	Bo Jacobsson [verfasserIn] Ulf Smith [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1972

Schlagwörter:	adipocyte size adipocyte number catecholamines

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 13(1972), 5, Seite 651-656
Übergeordnetes Werk:	volume:13 ; year:1972 ; number:5 ; pages:651-656

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/S0022-2275(20)39370-6

Katalog-ID:	DOAJ050561715

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520			\|a The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement.
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spelling	10.1016/S0022-2275(20)39370-6 doi (DE-627)DOAJ050561715 (DE-599)DOAJ3fff2f713341426bb19124c41c49fa5e DE-627 ger DE-627 rakwb eng QD415-436 Bo Jacobsson verfasserin aut Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells 1972 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement. adipocyte size adipocyte number catecholamines Biochemistry Ulf Smith verfasserin aut In Journal of Lipid Research Elsevier, 2021 13(1972), 5, Seite 651-656 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:13 year:1972 number:5 pages:651-656 https://doi.org/10.1016/S0022-2275(20)39370-6 kostenfrei https://doaj.org/article/3fff2f713341426bb19124c41c49fa5e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393706 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 1972 5 651-656
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allfieldsGer	10.1016/S0022-2275(20)39370-6 doi (DE-627)DOAJ050561715 (DE-599)DOAJ3fff2f713341426bb19124c41c49fa5e DE-627 ger DE-627 rakwb eng QD415-436 Bo Jacobsson verfasserin aut Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells 1972 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement. adipocyte size adipocyte number catecholamines Biochemistry Ulf Smith verfasserin aut In Journal of Lipid Research Elsevier, 2021 13(1972), 5, Seite 651-656 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:13 year:1972 number:5 pages:651-656 https://doi.org/10.1016/S0022-2275(20)39370-6 kostenfrei https://doaj.org/article/3fff2f713341426bb19124c41c49fa5e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393706 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 1972 5 651-656
allfieldsSound	10.1016/S0022-2275(20)39370-6 doi (DE-627)DOAJ050561715 (DE-599)DOAJ3fff2f713341426bb19124c41c49fa5e DE-627 ger DE-627 rakwb eng QD415-436 Bo Jacobsson verfasserin aut Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells 1972 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement. adipocyte size adipocyte number catecholamines Biochemistry Ulf Smith verfasserin aut In Journal of Lipid Research Elsevier, 2021 13(1972), 5, Seite 651-656 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:13 year:1972 number:5 pages:651-656 https://doi.org/10.1016/S0022-2275(20)39370-6 kostenfrei https://doaj.org/article/3fff2f713341426bb19124c41c49fa5e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393706 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 1972 5 651-656
language	English
source	In Journal of Lipid Research 13(1972), 5, Seite 651-656 volume:13 year:1972 number:5 pages:651-656
sourceStr	In Journal of Lipid Research 13(1972), 5, Seite 651-656 volume:13 year:1972 number:5 pages:651-656
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	adipocyte size adipocyte number catecholamines Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Bo Jacobsson @@aut@@ Ulf Smith @@aut@@
publishDateDaySort_date	1972-01-01T00:00:00Z
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The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. 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author	Bo Jacobsson
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topic_title	QD415-436 Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells adipocyte size adipocyte number catecholamines
topic	misc QD415-436 misc adipocyte size misc adipocyte number misc catecholamines misc Biochemistry
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title	Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
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title_full	Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
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title_sort	effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
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title_auth	Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
abstract	The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement.
abstractGer	The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement.
abstract_unstemmed	The lipolytic response to catecholamines and the antilipolytic effect of insulin were studied as a function of adipose cell size and number. The results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol (a β2-receptor agonist), noradrenaline, adrenaline, and isopropylnoradrenaline. The glycerol release induced by all these agents seems to be more favorably correlated with cell surface area than with cell volume or diameter.Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied. However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect. The results show that the larger adipose cells are at least as sensitive to the antilipolytic effect of insulin as the smaller cells.The results imply that the previously reported diminished responsiveness to insulin shown by large adipose cells is exerted only on the side of lipid accumulation. It is suggested that the negative correlation between cell size and responsiveness to insulin on the side of lipid accumulation may be one way to control adipose cell enlargement.
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title_short	Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
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Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells

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