Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway

The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to dete...
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Autor*in:	Lu Bai [verfasserIn] Di Zhang [verfasserIn] Tao-Tao Cui [verfasserIn] Ji-Fei Li [verfasserIn] Yang-Yang Gao [verfasserIn] Nan-Yi Wang [verfasserIn] Peng-Li Jia [verfasserIn] Hui-yuan Zhang [verfasserIn] Zhong-Ren Sun [verfasserIn] Wei Zou [verfasserIn] Long Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	electroacupuncture depression CAMK signaling pathway Baihui Shenting

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 14(2020)
Übergeordnetes Werk:	volume:14 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2020.563698

Katalog-ID:	DOAJ050598465

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520			\|a The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway.
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allfields	10.3389/fnbeh.2020.563698 doi (DE-627)DOAJ050598465 (DE-599)DOAJ88c71a16ecb346b58e51a54da4f140d9 DE-627 ger DE-627 rakwb eng RC321-571 Lu Bai verfasserin aut Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway. electroacupuncture depression CAMK signaling pathway Baihui Shenting Neurosciences. Biological psychiatry. Neuropsychiatry Di Zhang verfasserin aut Tao-Tao Cui verfasserin aut Ji-Fei Li verfasserin aut Yang-Yang Gao verfasserin aut Nan-Yi Wang verfasserin aut Peng-Li Jia verfasserin aut Hui-yuan Zhang verfasserin aut Zhong-Ren Sun verfasserin aut Wei Zou verfasserin aut Long Wang verfasserin aut In Frontiers in Behavioral Neuroscience Frontiers Media S.A., 2008 14(2020) (DE-627)579826392 (DE-600)2452960-6 16625153 nnns volume:14 year:2020 https://doi.org/10.3389/fnbeh.2020.563698 kostenfrei https://doaj.org/article/88c71a16ecb346b58e51a54da4f140d9 kostenfrei https://www.frontiersin.org/articles/10.3389/fnbeh.2020.563698/full kostenfrei https://doaj.org/toc/1662-5153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2020
spelling	10.3389/fnbeh.2020.563698 doi (DE-627)DOAJ050598465 (DE-599)DOAJ88c71a16ecb346b58e51a54da4f140d9 DE-627 ger DE-627 rakwb eng RC321-571 Lu Bai verfasserin aut Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway. electroacupuncture depression CAMK signaling pathway Baihui Shenting Neurosciences. Biological psychiatry. Neuropsychiatry Di Zhang verfasserin aut Tao-Tao Cui verfasserin aut Ji-Fei Li verfasserin aut Yang-Yang Gao verfasserin aut Nan-Yi Wang verfasserin aut Peng-Li Jia verfasserin aut Hui-yuan Zhang verfasserin aut Zhong-Ren Sun verfasserin aut Wei Zou verfasserin aut Long Wang verfasserin aut In Frontiers in Behavioral Neuroscience Frontiers Media S.A., 2008 14(2020) (DE-627)579826392 (DE-600)2452960-6 16625153 nnns volume:14 year:2020 https://doi.org/10.3389/fnbeh.2020.563698 kostenfrei https://doaj.org/article/88c71a16ecb346b58e51a54da4f140d9 kostenfrei https://www.frontiersin.org/articles/10.3389/fnbeh.2020.563698/full kostenfrei https://doaj.org/toc/1662-5153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2020
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authorswithroles_txt_mv	Lu Bai @@aut@@ Di Zhang @@aut@@ Tao-Tao Cui @@aut@@ Ji-Fei Li @@aut@@ Yang-Yang Gao @@aut@@ Nan-Yi Wang @@aut@@ Peng-Li Jia @@aut@@ Hui-yuan Zhang @@aut@@ Zhong-Ren Sun @@aut@@ Wei Zou @@aut@@ Long Wang @@aut@@
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callnumber-first	R - Medicine
author	Lu Bai
spellingShingle	Lu Bai misc RC321-571 misc electroacupuncture misc depression misc CAMK signaling pathway misc Baihui misc Shenting misc Neurosciences. Biological psychiatry. Neuropsychiatry Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
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topic_title	RC321-571 Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway electroacupuncture depression CAMK signaling pathway Baihui Shenting
topic	misc RC321-571 misc electroacupuncture misc depression misc CAMK signaling pathway misc Baihui misc Shenting misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc electroacupuncture misc depression misc CAMK signaling pathway misc Baihui misc Shenting misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
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title_full	Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
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author_browse	Lu Bai Di Zhang Tao-Tao Cui Ji-Fei Li Yang-Yang Gao Nan-Yi Wang Peng-Li Jia Hui-yuan Zhang Zhong-Ren Sun Wei Zou Long Wang
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title_sort	mechanisms underlying the antidepressant effect of acupuncture via the camk signaling pathway
callnumber	RC321-571
title_auth	Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
abstract	The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway.
abstractGer	The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway.
abstract_unstemmed	The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway.
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title_short	Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
url	https://doi.org/10.3389/fnbeh.2020.563698 https://doaj.org/article/88c71a16ecb346b58e51a54da4f140d9 https://www.frontiersin.org/articles/10.3389/fnbeh.2020.563698/full https://doaj.org/toc/1662-5153
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author2	Di Zhang Tao-Tao Cui Ji-Fei Li Yang-Yang Gao Nan-Yi Wang Peng-Li Jia Hui-yuan Zhang Zhong-Ren Sun Wei Zou Long Wang
author2Str	Di Zhang Tao-Tao Cui Ji-Fei Li Yang-Yang Gao Nan-Yi Wang Peng-Li Jia Hui-yuan Zhang Zhong-Ren Sun Wei Zou Long Wang
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up_date	2024-07-03T15:44:20.816Z
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Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepressant remains to be explored. In this study, we aimed to determine whether the ability of acupuncture at Baihui (GV20) and Shenting (GV24) points to treat depression is related to the regulation of key proteins in the CaMK pathway. A rat model of depression was induced by chronic unpredicted mild stress (CUMS). Model rats in the electroacupuncture group were subjected to acupuncture at the Baihui (GV20) and Shenting (GV24) acupoints once a day for 20 min. Model rats in the fluoxetine group were gavaged with fluoxetine (1.8 mg/kg). Immunohistochemistry and Western blotting assays were used to evaluate immunoreactivity for and the protein expression levels of CaMKII, CaMKIV, and CaM. The results showed that electroacupuncture had a significant effect in rats with depression. Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats. This indicates that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the CaMK signaling pathway.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">electroacupuncture</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CAMK signaling pathway</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Baihui</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Shenting</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurosciences. Biological psychiatry. 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Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway

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