Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<

Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella En...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Oscar Shirlaw [verfasserIn] Zara Billah [verfasserIn] Baraa Attar [verfasserIn] Lisa Hughes [verfasserIn] Rana M. Qasaymeh [verfasserIn] Veronique Seidel [verfasserIn] Georgios Efthimiou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	antibiofilm antivirulence Heather honey Manuka honey

Übergeordnetes Werk:	In: Antibiotics - MDPI AG, 2013, 9(2020), 12, p 911
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:12, p 911

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antibiotics9120911

Katalog-ID:	DOAJ050644025

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ050644025
003	DE-627
005	20240412205751.0
007	cr uuu---uuuuu
008	230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/antibiotics9120911 \|2 doi
035			\|a (DE-627)DOAJ050644025
035			\|a (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RM1-950
100	0		\|a Oscar Shirlaw \|e verfasserin \|4 aut
245	1	0	\|a Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.
650		4	\|a antibiofilm
650		4	\|a antivirulence
650		4	\|a Heather honey
650		4	\|a Manuka honey
650		4	\|a <i<Pseudomonas aeruginosa</i<
653		0	\|a Therapeutics. Pharmacology
700	0		\|a Zara Billah \|e verfasserin \|4 aut
700	0		\|a Baraa Attar \|e verfasserin \|4 aut
700	0		\|a Lisa Hughes \|e verfasserin \|4 aut
700	0		\|a Rana M. Qasaymeh \|e verfasserin \|4 aut
700	0		\|a Veronique Seidel \|e verfasserin \|4 aut
700	0		\|a Georgios Efthimiou \|e verfasserin \|4 aut
773	0	8	\|i In \|t Antibiotics \|d MDPI AG, 2013 \|g 9(2020), 12, p 911 \|w (DE-627)726120596 \|w (DE-600)2681345-2 \|x 20796382 \|7 nnns
773	1	8	\|g volume:9 \|g year:2020 \|g number:12, p 911
856	4	0	\|u https://doi.org/10.3390/antibiotics9120911 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2079-6382/9/12/911 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2079-6382 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 9 \|j 2020 \|e 12, p 911

Indexfelder

author_variant	o s os z b zb b a ba l h lh r m q rmq v s vs g e ge
matchkey_str	article:20796382:2020----::niiflatvtohahrnmnkhnyadniiuecptnilfoefhicnttetote
hierarchy_sort_str	2020
callnumber-subject-code	RM
publishDate	2020
allfields	10.3390/antibiotics9120911 doi (DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263 DE-627 ger DE-627 rakwb eng RM1-950 Oscar Shirlaw verfasserin aut Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys. antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology Zara Billah verfasserin aut Baraa Attar verfasserin aut Lisa Hughes verfasserin aut Rana M. Qasaymeh verfasserin aut Veronique Seidel verfasserin aut Georgios Efthimiou verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 12, p 911 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:12, p 911 https://doi.org/10.3390/antibiotics9120911 kostenfrei https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 kostenfrei https://www.mdpi.com/2079-6382/9/12/911 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 911
spelling	10.3390/antibiotics9120911 doi (DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263 DE-627 ger DE-627 rakwb eng RM1-950 Oscar Shirlaw verfasserin aut Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys. antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology Zara Billah verfasserin aut Baraa Attar verfasserin aut Lisa Hughes verfasserin aut Rana M. Qasaymeh verfasserin aut Veronique Seidel verfasserin aut Georgios Efthimiou verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 12, p 911 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:12, p 911 https://doi.org/10.3390/antibiotics9120911 kostenfrei https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 kostenfrei https://www.mdpi.com/2079-6382/9/12/911 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 911
allfields_unstemmed	10.3390/antibiotics9120911 doi (DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263 DE-627 ger DE-627 rakwb eng RM1-950 Oscar Shirlaw verfasserin aut Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys. antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology Zara Billah verfasserin aut Baraa Attar verfasserin aut Lisa Hughes verfasserin aut Rana M. Qasaymeh verfasserin aut Veronique Seidel verfasserin aut Georgios Efthimiou verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 12, p 911 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:12, p 911 https://doi.org/10.3390/antibiotics9120911 kostenfrei https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 kostenfrei https://www.mdpi.com/2079-6382/9/12/911 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 911
allfieldsGer	10.3390/antibiotics9120911 doi (DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263 DE-627 ger DE-627 rakwb eng RM1-950 Oscar Shirlaw verfasserin aut Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys. antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology Zara Billah verfasserin aut Baraa Attar verfasserin aut Lisa Hughes verfasserin aut Rana M. Qasaymeh verfasserin aut Veronique Seidel verfasserin aut Georgios Efthimiou verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 12, p 911 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:12, p 911 https://doi.org/10.3390/antibiotics9120911 kostenfrei https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 kostenfrei https://www.mdpi.com/2079-6382/9/12/911 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 911
allfieldsSound	10.3390/antibiotics9120911 doi (DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263 DE-627 ger DE-627 rakwb eng RM1-950 Oscar Shirlaw verfasserin aut Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys. antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology Zara Billah verfasserin aut Baraa Attar verfasserin aut Lisa Hughes verfasserin aut Rana M. Qasaymeh verfasserin aut Veronique Seidel verfasserin aut Georgios Efthimiou verfasserin aut In Antibiotics MDPI AG, 2013 9(2020), 12, p 911 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:9 year:2020 number:12, p 911 https://doi.org/10.3390/antibiotics9120911 kostenfrei https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 kostenfrei https://www.mdpi.com/2079-6382/9/12/911 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 911
language	English
source	In Antibiotics 9(2020), 12, p 911 volume:9 year:2020 number:12, p 911
sourceStr	In Antibiotics 9(2020), 12, p 911 volume:9 year:2020 number:12, p 911
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i< Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antibiotics
authorswithroles_txt_mv	Oscar Shirlaw @@aut@@ Zara Billah @@aut@@ Baraa Attar @@aut@@ Lisa Hughes @@aut@@ Rana M. Qasaymeh @@aut@@ Veronique Seidel @@aut@@ Georgios Efthimiou @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	726120596
id	DOAJ050644025
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ050644025</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412205751.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antibiotics9120911</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ050644025</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ128fba350d72424b888ee4f4d5b93263</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Oscar Shirlaw</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antibiofilm</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antivirulence</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heather honey</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Manuka honey</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Pseudomonas aeruginosa</i<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zara Billah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baraa Attar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rana M. Qasaymeh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Veronique Seidel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Efthimiou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antibiotics</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">9(2020), 12, p 911</subfield><subfield code="w">(DE-627)726120596</subfield><subfield code="w">(DE-600)2681345-2</subfield><subfield code="x">20796382</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 911</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antibiotics9120911</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/128fba350d72424b888ee4f4d5b93263</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2079-6382/9/12/911</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2079-6382</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 911</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Oscar Shirlaw
spellingShingle	Oscar Shirlaw misc RM1-950 misc antibiofilm misc antivirulence misc Heather honey misc Manuka honey misc <i<Pseudomonas aeruginosa</i< misc Therapeutics. Pharmacology Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
authorStr	Oscar Shirlaw
ppnlink_with_tag_str_mv	@@773@@(DE-627)726120596
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RM1-950
illustrated	Not Illustrated
issn	20796382
topic_title	RM1-950 Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i< antibiofilm antivirulence Heather honey Manuka honey <i<Pseudomonas aeruginosa</i<
topic	misc RM1-950 misc antibiofilm misc antivirulence misc Heather honey misc Manuka honey misc <i<Pseudomonas aeruginosa</i< misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc antibiofilm misc antivirulence misc Heather honey misc Manuka honey misc <i<Pseudomonas aeruginosa</i< misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc antibiofilm misc antivirulence misc Heather honey misc Manuka honey misc <i<Pseudomonas aeruginosa</i< misc Therapeutics. Pharmacology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Antibiotics
hierarchy_parent_id	726120596
hierarchy_top_title	Antibiotics
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)726120596 (DE-600)2681345-2
title	Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
ctrlnum	(DE-627)DOAJ050644025 (DE-599)DOAJ128fba350d72424b888ee4f4d5b93263
title_full	Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
author_sort	Oscar Shirlaw
journal	Antibiotics
journalStr	Antibiotics
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2020
contenttype_str_mv	txt
author_browse	Oscar Shirlaw Zara Billah Baraa Attar Lisa Hughes Rana M. Qasaymeh Veronique Seidel Georgios Efthimiou
container_volume	9
class	RM1-950
format_se	Elektronische Aufsätze
author-letter	Oscar Shirlaw
doi_str_mv	10.3390/antibiotics9120911
author2-role	verfasserin
title_sort	antibiofilm activity of heather and manuka honeys and antivirulence potential of some of their constituents on the dsba1 enzyme of <i<pseudomonas aeruginosa</i<
callnumber	RM1-950
title_auth	Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
abstract	Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.
abstractGer	Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.
abstract_unstemmed	Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	12, p 911
title_short	Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<
url	https://doi.org/10.3390/antibiotics9120911 https://doaj.org/article/128fba350d72424b888ee4f4d5b93263 https://www.mdpi.com/2079-6382/9/12/911 https://doaj.org/toc/2079-6382
remote_bool	true
author2	Zara Billah Baraa Attar Lisa Hughes Rana M. Qasaymeh Veronique Seidel Georgios Efthimiou
author2Str	Zara Billah Baraa Attar Lisa Hughes Rana M. Qasaymeh Veronique Seidel Georgios Efthimiou
ppnlink	726120596
callnumber-subject	RM - Therapeutics and Pharmacology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/antibiotics9120911
callnumber-a	RM1-950
up_date	2024-07-03T15:58:39.779Z
_version_	1803574123982487552
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ050644025</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412205751.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antibiotics9120911</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ050644025</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ128fba350d72424b888ee4f4d5b93263</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Oscar Shirlaw</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Heather honey was tested for its effect on the formation of biofilms by <i<Staphylococcus aureus</i<, <i<Pseudomonas aeruginosa</i<, <i<Escherichia coli</i<, <i<Klebsiella pneumoniae</i<, <i<Enterococcus faecalis</i<, <i<Salmonella Enteriditis</i< and <i<Acinetobacter baumanii</i< in comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in <i<S. aureus</i<, <i<A. baumanii</i<, <i<E. coli</i<, <i<S. Enteriditis</i< and <i<P. aeruginosa</i<, but promoted the growth of <i<E. faecalis</i< and <i<K. pneumoniae</i< biofilms. Manuka honey inhibited biofilm formation in <i<K. pneumoniae</i<, <i<E. faecalis</i<, and <i<S. Enteriditis</i<, <i<A. baumanii</i<, <i<E. coli</i< and <i<P. aeruginosa</i<, but promoted <i<S. aureus</i< biofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in <i<Pseudomonas aeruginosa</i<. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease in <i<P. aeruginosa</i< biofilm formation observed for such honeys.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antibiofilm</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antivirulence</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heather honey</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Manuka honey</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Pseudomonas aeruginosa</i<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zara Billah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baraa Attar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rana M. Qasaymeh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Veronique Seidel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Efthimiou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antibiotics</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">9(2020), 12, p 911</subfield><subfield code="w">(DE-627)726120596</subfield><subfield code="w">(DE-600)2681345-2</subfield><subfield code="x">20796382</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 911</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antibiotics9120911</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/128fba350d72424b888ee4f4d5b93263</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2079-6382/9/12/911</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2079-6382</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 911</subfield></datafield></record></collection>
score	7.401947

Nicht das Richtige dabei?

Schreiben Sie uns!

Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of <i<Pseudomonas aeruginosa</i<

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?