An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.

Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functi...
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Autor*in:	Lesley Tilleman [verfasserIn] Sasha De Henau [verfasserIn] Martje Pauwels [verfasserIn] Nora Nagy [verfasserIn] Isabel Pintelon [verfasserIn] Bart P Braeckman [verfasserIn] Karolien De Wael [verfasserIn] Sabine Van Doorslaer [verfasserIn] Dirk Adriaensen [verfasserIn] Jean-Pierre Timmermans [verfasserIn] Luc Moens [verfasserIn] Sylvia Dewilde [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 7(2012), 12, p e48768
Übergeordnetes Werk:	volume:7 ; year:2012 ; number:12, p e48768

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0048768

Katalog-ID:	DOAJ050694510

Internformat


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245	1	3	\|a An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
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520			\|a Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.
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700	0		\|a Isabel Pintelon \|e verfasserin \|4 aut
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700	0		\|a Sabine Van Doorslaer \|e verfasserin \|4 aut
700	0		\|a Dirk Adriaensen \|e verfasserin \|4 aut
700	0		\|a Jean-Pierre Timmermans \|e verfasserin \|4 aut
700	0		\|a Luc Moens \|e verfasserin \|4 aut
700	0		\|a Sylvia Dewilde \|e verfasserin \|4 aut
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912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
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publishDate	2012
allfields	10.1371/journal.pone.0048768 doi (DE-627)DOAJ050694510 (DE-599)DOAJ06ba03dc90a6484f97b231121d22dbe1 DE-627 ger DE-627 rakwb eng Lesley Tilleman verfasserin aut An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions. Medicine R Science Q Sasha De Henau verfasserin aut Martje Pauwels verfasserin aut Nora Nagy verfasserin aut Isabel Pintelon verfasserin aut Bart P Braeckman verfasserin aut Karolien De Wael verfasserin aut Sabine Van Doorslaer verfasserin aut Dirk Adriaensen verfasserin aut Jean-Pierre Timmermans verfasserin aut Luc Moens verfasserin aut Sylvia Dewilde verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 12, p e48768 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:12, p e48768 https://doi.org/10.1371/journal.pone.0048768 kostenfrei https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 12, p e48768
spelling	10.1371/journal.pone.0048768 doi (DE-627)DOAJ050694510 (DE-599)DOAJ06ba03dc90a6484f97b231121d22dbe1 DE-627 ger DE-627 rakwb eng Lesley Tilleman verfasserin aut An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions. Medicine R Science Q Sasha De Henau verfasserin aut Martje Pauwels verfasserin aut Nora Nagy verfasserin aut Isabel Pintelon verfasserin aut Bart P Braeckman verfasserin aut Karolien De Wael verfasserin aut Sabine Van Doorslaer verfasserin aut Dirk Adriaensen verfasserin aut Jean-Pierre Timmermans verfasserin aut Luc Moens verfasserin aut Sylvia Dewilde verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 12, p e48768 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:12, p e48768 https://doi.org/10.1371/journal.pone.0048768 kostenfrei https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 12, p e48768
allfields_unstemmed	10.1371/journal.pone.0048768 doi (DE-627)DOAJ050694510 (DE-599)DOAJ06ba03dc90a6484f97b231121d22dbe1 DE-627 ger DE-627 rakwb eng Lesley Tilleman verfasserin aut An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions. Medicine R Science Q Sasha De Henau verfasserin aut Martje Pauwels verfasserin aut Nora Nagy verfasserin aut Isabel Pintelon verfasserin aut Bart P Braeckman verfasserin aut Karolien De Wael verfasserin aut Sabine Van Doorslaer verfasserin aut Dirk Adriaensen verfasserin aut Jean-Pierre Timmermans verfasserin aut Luc Moens verfasserin aut Sylvia Dewilde verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 12, p e48768 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:12, p e48768 https://doi.org/10.1371/journal.pone.0048768 kostenfrei https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 12, p e48768
allfieldsGer	10.1371/journal.pone.0048768 doi (DE-627)DOAJ050694510 (DE-599)DOAJ06ba03dc90a6484f97b231121d22dbe1 DE-627 ger DE-627 rakwb eng Lesley Tilleman verfasserin aut An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions. Medicine R Science Q Sasha De Henau verfasserin aut Martje Pauwels verfasserin aut Nora Nagy verfasserin aut Isabel Pintelon verfasserin aut Bart P Braeckman verfasserin aut Karolien De Wael verfasserin aut Sabine Van Doorslaer verfasserin aut Dirk Adriaensen verfasserin aut Jean-Pierre Timmermans verfasserin aut Luc Moens verfasserin aut Sylvia Dewilde verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 12, p e48768 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:12, p e48768 https://doi.org/10.1371/journal.pone.0048768 kostenfrei https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 12, p e48768
allfieldsSound	10.1371/journal.pone.0048768 doi (DE-627)DOAJ050694510 (DE-599)DOAJ06ba03dc90a6484f97b231121d22dbe1 DE-627 ger DE-627 rakwb eng Lesley Tilleman verfasserin aut An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans. 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions. Medicine R Science Q Sasha De Henau verfasserin aut Martje Pauwels verfasserin aut Nora Nagy verfasserin aut Isabel Pintelon verfasserin aut Bart P Braeckman verfasserin aut Karolien De Wael verfasserin aut Sabine Van Doorslaer verfasserin aut Dirk Adriaensen verfasserin aut Jean-Pierre Timmermans verfasserin aut Luc Moens verfasserin aut Sylvia Dewilde verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 7(2012), 12, p e48768 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:7 year:2012 number:12, p e48768 https://doi.org/10.1371/journal.pone.0048768 kostenfrei https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 12, p e48768
language	English
source	In PLoS ONE 7(2012), 12, p e48768 volume:7 year:2012 number:12, p e48768
sourceStr	In PLoS ONE 7(2012), 12, p e48768 volume:7 year:2012 number:12, p e48768
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Lesley Tilleman @@aut@@ Sasha De Henau @@aut@@ Martje Pauwels @@aut@@ Nora Nagy @@aut@@ Isabel Pintelon @@aut@@ Bart P Braeckman @@aut@@ Karolien De Wael @@aut@@ Sabine Van Doorslaer @@aut@@ Dirk Adriaensen @@aut@@ Jean-Pierre Timmermans @@aut@@ Luc Moens @@aut@@ Sylvia Dewilde @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ050694510
language_de	englisch
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author	Lesley Tilleman
spellingShingle	Lesley Tilleman misc Medicine misc R misc Science misc Q An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
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topic_title	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans
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title	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
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title_full	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans
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author_browse	Lesley Tilleman Sasha De Henau Martje Pauwels Nora Nagy Isabel Pintelon Bart P Braeckman Karolien De Wael Sabine Van Doorslaer Dirk Adriaensen Jean-Pierre Timmermans Luc Moens Sylvia Dewilde
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title_sort	n-myristoylated globin with a redox-sensing function that regulates the defecation cycle in caenorhabditis elegans
title_auth	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
abstract	Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.
abstractGer	Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.
abstract_unstemmed	Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.
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title_short	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
url	https://doi.org/10.1371/journal.pone.0048768 https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBI https://doaj.org/toc/1932-6203
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up_date	2024-07-03T16:15:23.498Z
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An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.

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