The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma

To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the express...
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Autor*in:	Jingtao Wang MM [verfasserIn] Jimin Zhang MM [verfasserIn] Dongzhou Ma MM [verfasserIn] Xiushan Li MB [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Technology in Cancer Research & Treatment - SAGE Publishing, 2020, 19(2020)
Übergeordnetes Werk:	volume:19 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/1533033820977536

Katalog-ID:	DOAJ050714716

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allfields	10.1177/1533033820977536 doi (DE-627)DOAJ050714716 (DE-599)DOAJ2c9b01dd10dc4ed28f8866e0a2ccbe6f DE-627 ger DE-627 rakwb eng RC254-282 Jingtao Wang MM verfasserin aut The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jimin Zhang MM verfasserin aut Dongzhou Ma MM verfasserin aut Xiushan Li MB verfasserin aut In Technology in Cancer Research & Treatment SAGE Publishing, 2020 19(2020) (DE-627)507184734 (DE-600)2220436-2 15330338 nnns volume:19 year:2020 https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/article/2c9b01dd10dc4ed28f8866e0a2ccbe6f kostenfrei https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/toc/1533-0338 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020
spelling	10.1177/1533033820977536 doi (DE-627)DOAJ050714716 (DE-599)DOAJ2c9b01dd10dc4ed28f8866e0a2ccbe6f DE-627 ger DE-627 rakwb eng RC254-282 Jingtao Wang MM verfasserin aut The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jimin Zhang MM verfasserin aut Dongzhou Ma MM verfasserin aut Xiushan Li MB verfasserin aut In Technology in Cancer Research & Treatment SAGE Publishing, 2020 19(2020) (DE-627)507184734 (DE-600)2220436-2 15330338 nnns volume:19 year:2020 https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/article/2c9b01dd10dc4ed28f8866e0a2ccbe6f kostenfrei https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/toc/1533-0338 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020
allfields_unstemmed	10.1177/1533033820977536 doi (DE-627)DOAJ050714716 (DE-599)DOAJ2c9b01dd10dc4ed28f8866e0a2ccbe6f DE-627 ger DE-627 rakwb eng RC254-282 Jingtao Wang MM verfasserin aut The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jimin Zhang MM verfasserin aut Dongzhou Ma MM verfasserin aut Xiushan Li MB verfasserin aut In Technology in Cancer Research & Treatment SAGE Publishing, 2020 19(2020) (DE-627)507184734 (DE-600)2220436-2 15330338 nnns volume:19 year:2020 https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/article/2c9b01dd10dc4ed28f8866e0a2ccbe6f kostenfrei https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/toc/1533-0338 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020
allfieldsGer	10.1177/1533033820977536 doi (DE-627)DOAJ050714716 (DE-599)DOAJ2c9b01dd10dc4ed28f8866e0a2ccbe6f DE-627 ger DE-627 rakwb eng RC254-282 Jingtao Wang MM verfasserin aut The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jimin Zhang MM verfasserin aut Dongzhou Ma MM verfasserin aut Xiushan Li MB verfasserin aut In Technology in Cancer Research & Treatment SAGE Publishing, 2020 19(2020) (DE-627)507184734 (DE-600)2220436-2 15330338 nnns volume:19 year:2020 https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/article/2c9b01dd10dc4ed28f8866e0a2ccbe6f kostenfrei https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/toc/1533-0338 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020
allfieldsSound	10.1177/1533033820977536 doi (DE-627)DOAJ050714716 (DE-599)DOAJ2c9b01dd10dc4ed28f8866e0a2ccbe6f DE-627 ger DE-627 rakwb eng RC254-282 Jingtao Wang MM verfasserin aut The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jimin Zhang MM verfasserin aut Dongzhou Ma MM verfasserin aut Xiushan Li MB verfasserin aut In Technology in Cancer Research & Treatment SAGE Publishing, 2020 19(2020) (DE-627)507184734 (DE-600)2220436-2 15330338 nnns volume:19 year:2020 https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/article/2c9b01dd10dc4ed28f8866e0a2ccbe6f kostenfrei https://doi.org/10.1177/1533033820977536 kostenfrei https://doaj.org/toc/1533-0338 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020
language	English
source	In Technology in Cancer Research & Treatment 19(2020) volume:19 year:2020
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topic_facet	Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Technology in Cancer Research & Treatment
authorswithroles_txt_mv	Jingtao Wang MM @@aut@@ Jimin Zhang MM @@aut@@ Dongzhou Ma MM @@aut@@ Xiushan Li MB @@aut@@
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callnumber-first	R - Medicine
author	Jingtao Wang MM
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topic_title	RC254-282 The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma
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title_full	The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma
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title_sort	potential role of cers1 in autophagy through pi3k/akt signaling pathway in hypophysoma
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title_auth	The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma
abstract	To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway.
abstractGer	To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway.
abstract_unstemmed	To explore the role and mechanism of CERS1 in hypophysoma and investigate whether CERS1 overexpression can change the autophagy process of hypophysoma, and then to explore whether CERS1’s effect was regulated by the PI3K/AKT signaling pathway. Western blot and RT-PCR were used to analyze the expression or mRNA level of CERS1 at different tissues or cell lines. Afterwards, the occurrence and development of hypophysoma in vivo and in vitro, respectively, was observed by using CERS1 overexpression by lentivirus. Finally, MK-2206 and LY294002 were applied to discuss whether the role of CERS1 was regulated by the PI3K/AKT signaling pathway. Results show that the CERS1 expression and mRNA level in tumor or AtT-20 cells were decreased. CERS1 over-expressed by lentivirus could inhibit hypophysoma development in vivo and in vitro by reducing tumor volume and weight, weakening tumor proliferation and invasion, and enhancing apoptosis. In addition, shCERS1 could reverse the process. The above results indicate that CERS1 is possibly able to enhance autophagy in hypophysoma through the PI3K/AKT signaling pathway.
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title_short	The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma
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