Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes

<p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Weill Mylène [verfasserIn] Agnew Philip [verfasserIn] Duchon Stéphane [verfasserIn] Bonnet Julien [verfasserIn] Berticat Claire [verfasserIn] Corbel Vincent [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Evolutionary Biology - BMC, 2003, 8(2008), 1, p 104
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1, p 104

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2148-8-104

Katalog-ID:	DOAJ050738844

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p<
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912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
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author_variant	w m wm a p ap d s ds b j bj b c bc c v cv
matchkey_str	article:14712148:2008----::otadeeisfutpeeitneonetcdsoiclxunu
hierarchy_sort_str	2008
callnumber-subject-code	QH
publishDate	2008
allfields	10.1186/1471-2148-8-104 doi (DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda DE-627 ger DE-627 rakwb eng QH359-425 Weill Mylène verfasserin aut Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Evolution Agnew Philip verfasserin aut Duchon Stéphane verfasserin aut Bonnet Julien verfasserin aut Berticat Claire verfasserin aut Corbel Vincent verfasserin aut In BMC Evolutionary Biology BMC, 2003 8(2008), 1, p 104 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:8 year:2008 number:1, p 104 https://doi.org/10.1186/1471-2148-8-104 kostenfrei https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda kostenfrei http://www.biomedcentral.com/1471-2148/8/104 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 104
spelling	10.1186/1471-2148-8-104 doi (DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda DE-627 ger DE-627 rakwb eng QH359-425 Weill Mylène verfasserin aut Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Evolution Agnew Philip verfasserin aut Duchon Stéphane verfasserin aut Bonnet Julien verfasserin aut Berticat Claire verfasserin aut Corbel Vincent verfasserin aut In BMC Evolutionary Biology BMC, 2003 8(2008), 1, p 104 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:8 year:2008 number:1, p 104 https://doi.org/10.1186/1471-2148-8-104 kostenfrei https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda kostenfrei http://www.biomedcentral.com/1471-2148/8/104 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 104
allfields_unstemmed	10.1186/1471-2148-8-104 doi (DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda DE-627 ger DE-627 rakwb eng QH359-425 Weill Mylène verfasserin aut Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Evolution Agnew Philip verfasserin aut Duchon Stéphane verfasserin aut Bonnet Julien verfasserin aut Berticat Claire verfasserin aut Corbel Vincent verfasserin aut In BMC Evolutionary Biology BMC, 2003 8(2008), 1, p 104 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:8 year:2008 number:1, p 104 https://doi.org/10.1186/1471-2148-8-104 kostenfrei https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda kostenfrei http://www.biomedcentral.com/1471-2148/8/104 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 104
allfieldsGer	10.1186/1471-2148-8-104 doi (DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda DE-627 ger DE-627 rakwb eng QH359-425 Weill Mylène verfasserin aut Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Evolution Agnew Philip verfasserin aut Duchon Stéphane verfasserin aut Bonnet Julien verfasserin aut Berticat Claire verfasserin aut Corbel Vincent verfasserin aut In BMC Evolutionary Biology BMC, 2003 8(2008), 1, p 104 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:8 year:2008 number:1, p 104 https://doi.org/10.1186/1471-2148-8-104 kostenfrei https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda kostenfrei http://www.biomedcentral.com/1471-2148/8/104 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 104
allfieldsSound	10.1186/1471-2148-8-104 doi (DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda DE-627 ger DE-627 rakwb eng QH359-425 Weill Mylène verfasserin aut Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p< Evolution Agnew Philip verfasserin aut Duchon Stéphane verfasserin aut Bonnet Julien verfasserin aut Berticat Claire verfasserin aut Corbel Vincent verfasserin aut In BMC Evolutionary Biology BMC, 2003 8(2008), 1, p 104 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:8 year:2008 number:1, p 104 https://doi.org/10.1186/1471-2148-8-104 kostenfrei https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda kostenfrei http://www.biomedcentral.com/1471-2148/8/104 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 104
language	English
source	In BMC Evolutionary Biology 8(2008), 1, p 104 volume:8 year:2008 number:1, p 104
sourceStr	In BMC Evolutionary Biology 8(2008), 1, p 104 volume:8 year:2008 number:1, p 104
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Evolution
isfreeaccess_bool	true
container_title	BMC Evolutionary Biology
authorswithroles_txt_mv	Weill Mylène @@aut@@ Agnew Philip @@aut@@ Duchon Stéphane @@aut@@ Bonnet Julien @@aut@@ Berticat Claire @@aut@@ Corbel Vincent @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
hierarchy_top_id	32664489X
id	DOAJ050738844
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ050738844</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308154703.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2008 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1471-2148-8-104</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ050738844</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH359-425</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Weill Mylène</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. 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callnumber-first	Q - Science
author	Weill Mylène
spellingShingle	Weill Mylène misc QH359-425 misc Evolution Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
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topic_title	QH359-425 Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
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title	Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
ctrlnum	(DE-627)DOAJ050738844 (DE-599)DOAJd5d846efcf6c412981b92f8ef9833dda
title_full	Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
author_sort	Weill Mylène
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author_browse	Weill Mylène Agnew Philip Duchon Stéphane Bonnet Julien Berticat Claire Corbel Vincent
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author-letter	Weill Mylène
doi_str_mv	10.1186/1471-2148-8-104
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title_sort	costs and benefits of multiple resistance to insecticides for <it<culex quinquefasciatus </it<mosquitoes
callnumber	QH359-425
title_auth	Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
abstract	<p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. In cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. We compared <it<Culex quinquefasciatus </it<mosquitoes harbouring two resistance alleles <it<ace-1</it<<sup<<it<R </it<</sup<and <it<Kdr</it<<sup<<it<R </it<</sup<(conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. Comparisons were made in environments where both, only one, or neither type of insecticide was present.</p< <p<Results</p< <p<Each resistance allele was associated with fitness costs (survival to adulthood) in an insecticide-free environment, with the costs of <it<ace-1</it<<sup<<it<R </it<</sup<being greater than for <it<Kdr</it<<sup<<it<R</it<</sup<. However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. Additional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.</p<
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container_issue	1, p 104
title_short	Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes
url	https://doi.org/10.1186/1471-2148-8-104 https://doaj.org/article/d5d846efcf6c412981b92f8ef9833dda http://www.biomedcentral.com/1471-2148/8/104 https://doaj.org/toc/1471-2148
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However, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring <it<ace-1</it<<sup<<it<R </it<</sup<alone. The two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations.</p< <p<Conclusion</p< <p<Insecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. In particular, the presence of the <it<Kdr</it<<sup<<it<R </it<</sup<mutation compensated for the costs of the <it<ace-1</it<<sup<<it<R </it<</sup<mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. 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Costs and benefits of multiple resistance to insecticides for <it<Culex quinquefasciatus </it<mosquitoes

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