A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in...
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Autor*in:	Yan Mei [verfasserIn] Chao Zhou [verfasserIn] Chao-Yong Liang [verfasserIn] Guan-Ming Lu [verfasserIn] Mu-Sheng Zeng [verfasserIn] Jin-Jin Wang [verfasserIn] Guo-Kai Feng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in

Übergeordnetes Werk:	In: MethodsX - Elsevier, 2015, 7(2020), Seite 100921-
Übergeordnetes Werk:	volume:7 ; year:2020 ; pages:100921-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.mex.2020.100921

Katalog-ID:	DOAJ05073931X

Internformat


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520			\|a Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC.
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publishDate	2020
allfields	10.1016/j.mex.2020.100921 doi (DE-627)DOAJ05073931X (DE-599)DOAJa1c1955ff54447b38a179494e9594920 DE-627 ger DE-627 rakwb eng Yan Mei verfasserin aut A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC. c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q Chao Zhou verfasserin aut Chao-Yong Liang verfasserin aut Guan-Ming Lu verfasserin aut Mu-Sheng Zeng verfasserin aut Jin-Jin Wang verfasserin aut Guo-Kai Feng verfasserin aut In MethodsX Elsevier, 2015 7(2020), Seite 100921- (DE-627)832786675 (DE-600)2830212-6 22150161 nnns volume:7 year:2020 pages:100921- https://doi.org/10.1016/j.mex.2020.100921 kostenfrei https://doaj.org/article/a1c1955ff54447b38a179494e9594920 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215016120301400 kostenfrei https://doaj.org/toc/2215-0161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2020 100921-
spelling	10.1016/j.mex.2020.100921 doi (DE-627)DOAJ05073931X (DE-599)DOAJa1c1955ff54447b38a179494e9594920 DE-627 ger DE-627 rakwb eng Yan Mei verfasserin aut A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC. c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q Chao Zhou verfasserin aut Chao-Yong Liang verfasserin aut Guan-Ming Lu verfasserin aut Mu-Sheng Zeng verfasserin aut Jin-Jin Wang verfasserin aut Guo-Kai Feng verfasserin aut In MethodsX Elsevier, 2015 7(2020), Seite 100921- (DE-627)832786675 (DE-600)2830212-6 22150161 nnns volume:7 year:2020 pages:100921- https://doi.org/10.1016/j.mex.2020.100921 kostenfrei https://doaj.org/article/a1c1955ff54447b38a179494e9594920 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215016120301400 kostenfrei https://doaj.org/toc/2215-0161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2020 100921-
allfields_unstemmed	10.1016/j.mex.2020.100921 doi (DE-627)DOAJ05073931X (DE-599)DOAJa1c1955ff54447b38a179494e9594920 DE-627 ger DE-627 rakwb eng Yan Mei verfasserin aut A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC. c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q Chao Zhou verfasserin aut Chao-Yong Liang verfasserin aut Guan-Ming Lu verfasserin aut Mu-Sheng Zeng verfasserin aut Jin-Jin Wang verfasserin aut Guo-Kai Feng verfasserin aut In MethodsX Elsevier, 2015 7(2020), Seite 100921- (DE-627)832786675 (DE-600)2830212-6 22150161 nnns volume:7 year:2020 pages:100921- https://doi.org/10.1016/j.mex.2020.100921 kostenfrei https://doaj.org/article/a1c1955ff54447b38a179494e9594920 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215016120301400 kostenfrei https://doaj.org/toc/2215-0161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2020 100921-
allfieldsGer	10.1016/j.mex.2020.100921 doi (DE-627)DOAJ05073931X (DE-599)DOAJa1c1955ff54447b38a179494e9594920 DE-627 ger DE-627 rakwb eng Yan Mei verfasserin aut A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC. c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q Chao Zhou verfasserin aut Chao-Yong Liang verfasserin aut Guan-Ming Lu verfasserin aut Mu-Sheng Zeng verfasserin aut Jin-Jin Wang verfasserin aut Guo-Kai Feng verfasserin aut In MethodsX Elsevier, 2015 7(2020), Seite 100921- (DE-627)832786675 (DE-600)2830212-6 22150161 nnns volume:7 year:2020 pages:100921- https://doi.org/10.1016/j.mex.2020.100921 kostenfrei https://doaj.org/article/a1c1955ff54447b38a179494e9594920 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215016120301400 kostenfrei https://doaj.org/toc/2215-0161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2020 100921-
allfieldsSound	10.1016/j.mex.2020.100921 doi (DE-627)DOAJ05073931X (DE-599)DOAJa1c1955ff54447b38a179494e9594920 DE-627 ger DE-627 rakwb eng Yan Mei verfasserin aut A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC. c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q Chao Zhou verfasserin aut Chao-Yong Liang verfasserin aut Guan-Ming Lu verfasserin aut Mu-Sheng Zeng verfasserin aut Jin-Jin Wang verfasserin aut Guo-Kai Feng verfasserin aut In MethodsX Elsevier, 2015 7(2020), Seite 100921- (DE-627)832786675 (DE-600)2830212-6 22150161 nnns volume:7 year:2020 pages:100921- https://doi.org/10.1016/j.mex.2020.100921 kostenfrei https://doaj.org/article/a1c1955ff54447b38a179494e9594920 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215016120301400 kostenfrei https://doaj.org/toc/2215-0161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2020 100921-
language	English
source	In MethodsX 7(2020), Seite 100921- volume:7 year:2020 pages:100921-
sourceStr	In MethodsX 7(2020), Seite 100921- volume:7 year:2020 pages:100921-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in Science Q
isfreeaccess_bool	true
container_title	MethodsX
authorswithroles_txt_mv	Yan Mei @@aut@@ Chao Zhou @@aut@@ Chao-Yong Liang @@aut@@ Guan-Ming Lu @@aut@@ Mu-Sheng Zeng @@aut@@ Jin-Jin Wang @@aut@@ Guo-Kai Feng @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	832786675
id	DOAJ05073931X
language_de	englisch
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author	Yan Mei
spellingShingle	Yan Mei misc c-Myc misc Transgenic mouse model misc Hepatocellular carcinoma misc Knock-in misc Science misc Q A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
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topic_title	A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma c-Myc Transgenic mouse model Hepatocellular carcinoma Knock-in
topic	misc c-Myc misc Transgenic mouse model misc Hepatocellular carcinoma misc Knock-in misc Science misc Q
topic_unstemmed	misc c-Myc misc Transgenic mouse model misc Hepatocellular carcinoma misc Knock-in misc Science misc Q
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title	A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
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title_full	A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
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author_browse	Yan Mei Chao Zhou Chao-Yong Liang Guan-Ming Lu Mu-Sheng Zeng Jin-Jin Wang Guo-Kai Feng
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format_se	Elektronische Aufsätze
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title_sort	method to establish a c-myc transgenic mouse model of hepatocellular carcinoma
title_auth	A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
abstract	Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC.
abstractGer	Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC.
abstract_unstemmed	Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates.The advantages of this mouse model are as follows: • This method developed a H11LNL-Myc knock-in HCC mouse model by crossing H11LNL-Myc heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. • The c-Myc/Alb-cre double-positive mice exhibited a typical HCC phenotype, and showed accelerated tumor initiation and rapid HCC progression. Early stage HCC tumors (2–3 mm in diameter) were observed in male mice at the age of 47 days and in female mice at the age of 60 days. • Approximately 3 months later, the HCC tumors had progressed to a late stage (< 1 cm in diameter), and 100% of the male and female mice had HCC.
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title_short	A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma
url	https://doi.org/10.1016/j.mex.2020.100921 https://doaj.org/article/a1c1955ff54447b38a179494e9594920 http://www.sciencedirect.com/science/article/pii/S2215016120301400 https://doaj.org/toc/2215-0161
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up_date	2024-07-03T16:30:34.656Z
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A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma

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